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The establishment of anterograde tracing label of vagus nerve terminal in mice.-Resolution of the onset of hiding deabetes-

Research Project

Project/Area Number 24659091
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General anatomy (including Histology/Embryology)
Research InstitutionShowa University

Principal Investigator

Funahashi Hisayuki  昭和大学, 医学部, 准教授 (20317514)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords神経標識
Outline of Final Research Achievements

The goal the present study is to clarify the onset mechanism of the hiding diabetes. Melanocortin-4 receptor(MC4-R) has been noticed as critical regulator of insulin secretion. Morphological and histochemical analysis on MC4-R GFP mice indicates that the possibilities that the DMV neurons directly project to B cell in the pancreas. The method to efficiently label the vagus nerve terminals with anterograde tracer has been examined. The interesting combination of the tracer conjugated with special fluorescence agent and high sensible detector “IVIS Imaging system” may produce not only time-saving of the work but also decrease of a number of mice sacrified has been found. The working condition of the tracer is problem to be solved in the future.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013 2012

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (3 results) Book (1 results)

  • [Journal Article] 高酸素負荷新生仔ラットの脳障害モデルとしての有用性の検討2015

    • Author(s)
      佐藤千佳、舟橋久幸
    • Journal Title

      昭和学士会雑誌

      Volume: 75 Pages: 450-457

    • NAID

      130005121287

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Static and Dynamic Hypergravity Responses of Osteoblasts and Osteoclasts in Medaka Scales2013

    • Author(s)
      Yano S, et al. (14番目)
    • Journal Title

      Zoological Science

      Volume: 30 Issue: 3 Pages: 217-223

    • DOI

      10.2108/zsj.30.217

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area.2012

    • Author(s)
      Cui H.
    • Journal Title

      J Comp Neurol

      Volume: 520(18) Issue: 18 Pages: 4168-83

    • DOI

      10.1002/cne.23145

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Shared features of S100B immunohistochemistry and cytochrome oxidase histochemistry in the ventroposterior thalamus and lateral habenula in neonatal rats.2012

    • Author(s)
      Muneoka K.
    • Journal Title

      Int J Dev Neurosci

      Volume: 30(6) Issue: 6 Pages: 499-505

    • DOI

      10.1016/j.ijdevneu.2012.05.003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 魚類のウロコを用いた評価系の開発と骨代謝研究への応用2012

    • Author(s)
      鈴木信雄
    • Journal Title

      The Magnetics Society of Japan

      Volume: 7(4) Pages: 174-178

    • Related Report
      2012 Research-status Report
  • [Journal Article] Determination of Calcium Sensing Receptor in the Scales of Goldfish and Induction of Its mRNA Expression by Acceleration Loading.2012

    • Author(s)
      Makiko Kakikawa
    • Journal Title

      Biological Sciences in Space.

      Volume: 26 Pages: 26-31

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 走査型及び透過型電子顕微鏡によるキンギョウロコの収納ポケットの形態観察2014

    • Author(s)
      舟橋久幸
    • Organizer
      日本臨床分子形態学会
    • Place of Presentation
      TKP市ヶ谷カンファレンスセンター
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 走査型電子顕微鏡の有用性 走査型電子顕微鏡によるキンギョウロコの収納ポケットの形態観察2013

    • Author(s)
      舟橋久幸
    • Organizer
      日本臨床分子形態学会
    • Place of Presentation
      アクロス福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] キンギョの再生ウロコにおける隆起線形成リズム2012

    • Author(s)
      黒田美翔
    • Organizer
      日本比較内分泌学会
    • Place of Presentation
      福井大学
    • Related Report
      2012 Research-status Report
  • [Book] 動物の事典2016

    • Author(s)
      舟橋久幸
    • Total Pages
      3
    • Publisher
      朝倉書店
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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