| Project/Area Number |
24659102
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
SEO Yoshiteru 獨協医科大学, 医学部, 教授 (90179317)
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Tadashi 独立行政法人海洋研究開発機構, 海洋•極限環境生物圏領域, プログラムディレクター (90373464)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 内皮細胞性血管弛緩因子 / 深海性海洋生物 / 化学合成共生動物 / MRI / 血流計測 / 循環器 / 血流測定 |
|---|
| Research Abstract |
In order to test whether H2S is the endothelium-derived relaxing factor (EDRF) or not, we plan to use deep sea bivalves as model animals, since these bivalves live in a high H2S environment. MRI methods to analyse cardiovascular functions were developed by using Mytilus galloprovincialis. Bathymodiolus japonicus and Bathymodiolus platifrons presented higher tolerance to H2S compared with Mytilus. Therefore, deep sea bivalves must be useful experimental animal for analysing EDRF.
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