Challenge to improve dry mouth through the TRP channel by spice

• Project/Area Number: 24659105
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kanazawa University
• Principal Investigator: SUGIMOTO Naotoshi 金沢大学, 医学系, 准教授 (80272954)
• Co-Investigator(Kenkyū-buntansha): SHIDO Osamu 島根大学, 医学部, 教授 (40175386)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 香辛料 / 暑熱順化 / ＴＲＰチャネル / 環境 / 生理学

Research Abstract

We realize the greatness of saliva in the meal time. However, xerostomia which saliva secretion reduction is originating increases, and xerostomia serves as a big social problem in recent years. In addition, the current situation is that elder people are brought to increase, xerostomia of the elder people can not be ignored. We showed a possibility that a warming and spices could improve the QOL of mouth dryness through this research. And I proved not a little also about the molecular mechanism. I am sure that the result of this research contributes not only to elderly people but to people troubled with xerostomia.

Research Products

• [Journal Article] 3-Dimensional Tissue is Formed from Cancer Cells In Vitro on Gelfoam®, but not on MatrigelTM. (2014)
  • Author(s): Tome Y, Uehara F, Mii S, Yano S, Zhang L, Sugiomto N, Maehara H, Bouvet M, Tsutiya H, Kanaya F, Hoffman RM.
  • Journal Title: J Cell Biochem. Volume: In press Issue: 8 Pages: 1362-1367
  • DOI: 10.1002/jcb.24780
  • Peer Reviewed
• [Journal Article] Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B (2014)
  • Author(s): Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A
  • Journal Title: Nutr Cancer Volume: 66(3) Issue: 3 Pages: 419-23
  • DOI: 10.1080/01635581.2013.877497
  • Peer Reviewed
• [Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells (2014)
  • Author(s): Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
  • Journal Title: Cell biochemistry and biophysics Volume: (in press) Issue: 1 Pages: 301-7
  • DOI: 10.1007/s12013-014-9912-9
  • Peer Reviewed
• [Journal Article] Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats (2013)
  • Author(s): Sugimoto N, Matsuzaki K, Ishibashi H, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Sekine J, Koizumi S, Yachie A, Umehara H and Shido O
  • Journal Title: Scientific Reports Volume: 3 Issue: 1 Pages: 1763-1763
  • DOI: 10.1038/srep01763
  • Peer Reviewed
• [Journal Article] Targeted activation of PKA and Epac promotes glioblastoma regression in vitro (2013)
  • Author(s): Sugimoto N, Miwa S, Tsuchiya H, Hitomi Y, Nakamura H, Yachie A, Koizumi S
  • Journal Title: Mol Clin Oncol Volume: 1(2) Issue: 2 Pages: 281-285
  • DOI: 10.3892/mco.2013.65
  • Peer Reviewed
• [Journal Article] Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis. (2013)
  • Author(s): Ishikawa S, Shimizu M, Ueno K, Sugimoto N, Yachie A.
  • Journal Title: Cytokine Volume: 62 Issue: 2 Pages: 272-277
  • DOI: 10.1016/j.cyto.2013.03.007
  • NAID: 130007956852
  • Peer Reviewed
• [Journal Article] Real-time Imaging ofαv Integrin Molecular Dynamics in Osteosarcoma Cells In Vitro and In Vivo (2013)
  • Author(s): Tome Y, Sugimoto N, Yano S, Momiyama M, Mii S, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
  • Journal Title: Anticancer Res Volume: 33 Pages: 3021-3025
  • Peer Reviewed
• [Journal Article] High Lung-metastatic Variant of Human Osteosarcoma Cells, Selected by Passage of Lung Metastasis in Nude Mice, Is Associated with Increased Expression ofαvβ3 Integrin (2013)
  • Author(s): Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
  • Journal Title: Anticancer Res Volume: 33 Pages: 3623-3628
  • Peer Reviewed
• [Journal Article] Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy (2013)
  • Author(s): Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM
  • Journal Title: J Cell Biochem Volume: 114(11) Issue: 11 Pages: 2454-60
  • DOI: 10.1002/jcb.24593
  • Peer Reviewed
• [Journal Article] Lactobacillus casei cell wall extract directly stimulates the expression of COX2 independent of Toll-like receptor 2 in rat glial cells (2013)
  • Author(s): Sugimoto N, Ohta K, Saito T, Nakayama Y, Nakamura T, Maeda A, Yachie A.
  • Journal Title: J Microbiol Immunol Infect. Volume: 46 Issue: 5 Pages: 389-92
  • DOI: 10.1016/j.jmii.2012.03.004
  • NAID: 120004161555
  • Peer Reviewed
• [Journal Article] Real-time Imaging of αv Integrin Molecular Dynamics in Osteosarcoma Cells In Vitro and In Vivo. (2013)
  • Author(s): Tome Y, Sugimoto N, Yano S, Momiyama M, Mii S, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM.
  • Journal Title: Anticancer Res. Volume: 33 Pages: 3021-3025
  • Peer Reviewed
• [Journal Article] High Lung-metastatic Variant of Human Osteosarcoma Cells, Selected by Passage of Lung Metastasis in Nude Mice, Is Associated with Increased Expression of αvβ3 Integrin. (2013)
  • Author(s): Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM.
  • Journal Title: Anticancer Res Volume: 33 Pages: 3623-3628
  • Peer Reviewed
• [Journal Article] Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration (2012)
  • Author(s): Suganuma S, Tada K, Hayashi K, Takeuchi A, Sugimoto N, Ikeda K, Tsuchiya H
  • Journal Title: J Orthop Sci Volume: 18 Issue: 1 Pages: 145-51
  • DOI: 10.1007/s00776-012-0306-9
  • Peer Reviewed
• [Journal Article] Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells (2012)
  • Author(s): Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
  • Journal Title: Cell Physiol Biochem. Volume: 30 Issue: 2 Pages: 450-457
  • DOI: 10.1159/000339038
  • Peer Reviewed
• [Journal Article] Skewed Production of IL-6 and TGFß by Cultured Salivary Gland Epithelial Cells from Patients with Sjögren's Syndrome (2012)
  • Author(s): Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Nakamura T, Sato T, Tanaka M, Masaki Y, Fukushima T, Hirose Y, Sugimoto N, Okazaki T, Umehara H
  • Journal Title: Plos One Volume: 7
  • Peer Reviewed
• [Journal Article] Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-κB and MAPK activations and cell proliferation through protein kinase A- or exchange protein activated by cAMP-dependent signal pathway (2012)
  • Author(s): Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomo Y, Nakamura H, Koizumi S, Yachie A
  • Journal Title: ScientificWorldJournal Volume: 2012 Pages: 748572-748572
• [Journal Article] Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87-MG human malignant glioma cells (2012)
  • Author(s): Echigo R, Sugimoto N, Yachie A
  • Journal Title: Oncol Rep Volume: 28 Pages: 1176-1180
  • NAID: 120005285923
  • Peer Reviewed
• [Journal Article] Caffeine Induces Apoptosis of Osteosarcoma Cells by Inhibiting AKT/mTOR/S6K, NF-κB and MAPK Pathways (2012)
  • Author(s): Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 23 Pages: 3643-3649
  • Peer Reviewed
• [Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptorαchain gene between atopic dermatitis and Japanese cedar pollinosis (2012)
  • Author(s): Tanaka T, HitomiY, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata A, Sugimoto N, Hatta K, Eboshida A, Konoshita T, Nakamura H
  • Journal Title: Allergol Int Volume: 61 Pages: 57-63
  • NAID: 130004873044
  • Peer Reviewed
• [Journal Article] Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A-or Exchange Protein Activated by cAMP-Dependent Signal Pathway (2012)
  • Author(s): Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomi Y, Nakamura H, Koizumi S, Yachie A
  • Journal Title: The Scientific World Journal Volume: 2012 Pages: 748572-748572
  • DOI: 10.1100/2012/748572
  • Peer Reviewed
• [Journal Article] Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells (2012)
  • Author(s): Ryosuke Echigo
  • Journal Title: Oncology Reports Volume: 28 Issue: 4 Pages: 1176-1180
  • DOI: 10.3892/or.2012.1937
  • Peer Reviewed
• [Journal Article] Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. (2012)
  • Author(s): Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H.
  • Journal Title: Anticancer Res. Volume: 32 Pages: 3643-3649
  • Peer Reviewed
• [Journal Article] Skewed production of IL-6 and TGFbeta by cultured salivary gland epithelial cells from patients with Sjogren's syndrome (2012)
  • Author(s): Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Nakamura T, Sato T, Fujita Y, Tanaka M, Masaki Y, Fukushima T, Hirose Y, Taniguchi M, Sugimoto N, Okazaki T and Umehara H
  • Journal Title: PLoS One Volume: 7 Issue: 10 Pages: e45689-e45689
  • DOI: 10.1371/journal.pone.0045689
  • Peer Reviewed
• [Presentation] 低酸素環境下でのがん細胞の動向 (2014)
  • Author(s): 杉本直俊、少作隆子、松崎健太郎、片倉賢紀、紫藤治
  • Organizer: 第9回環境生理学プレコングス
  • Place of Presentation: 国民宿舎レインボー桜島(鹿児島県)
  • Year and Date: 2014-03-15
• [Presentation] 食と若返り (2013)
  • Author(s): 杉本直俊
  • Organizer: 第一回食と環境、そして高齢化を考える研究会
  • Place of Presentation: ホテル日航金沢(石川県)
  • Year and Date: 2013-11-22
• [Presentation] 熱耐性能獲得細胞からの熱中症予防関連分子の同定 (2013)
  • Author(s): 杉本直俊、松崎健太郎、片倉賢紀、紫藤治
  • Organizer: 第52回日本生気象学会大会
  • Place of Presentation: 米子市文化ホール(鳥取県)
  • Year and Date: 2013-11-02
• [Presentation] アミロイド-β脳室内投与によるラット行動性体温調節機能の変化 (2013)
  • Author(s): 松崎健太郎、片倉賢紀、杉本直俊、宮本まゆみ、原俊子、紫藤治
  • Organizer: 第52回日本生気象学会大会
  • Place of Presentation: 米子市文化ホール(鳥取県)
  • Year and Date: 2013-11-02
• [Presentation] 高齢者の骨格筋の役割―体温調節と水分代謝の視点からの考察― (2013)
  • Author(s): 杉本直俊
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 日本教育会館・学術総合センター(東京都)
  • Year and Date: 2013-09-21
• [Presentation] 細胞から熱中症予防を考える (2013)
  • Author(s): 杉本直俊
  • Organizer: 第27回運動と体温の研究会
  • Place of Presentation: 立教大学池袋キャンパス(東京都)
  • Year and Date: 2013-09-20
• [Presentation] 培養細胞を用いた暑熱馴化の研究 (2013)
  • Author(s): 杉本直俊、松崎健太郎、紫藤治
  • Organizer: 第8回環境生理学プレコングレス
  • Place of Presentation: 東京女子医科大学・早稲田大卓連携先端生命医科学研究教育施設(TWIns)(東京都)
  • Year and Date: 2013-03-26
• [Presentation] ラット暑熱馴化形成時の唾液分泌機能変化 (2012)
  • Author(s): 松崎健太郎、杉本直俊、宮本まゆみ、原俊子、紫藤治
  • Place of Presentation: キッセイ文化ホール(長野県)
  • Year and Date: 2012-11-08
• [Presentation] 短期～長期温熱刺激が細胞のheat toleranceへ与える影響 (2012)
  • Author(s): 杉本直俊、松崎健太郎、紫藤治
  • Organizer: 第51回日本生気象学会大会
  • Place of Presentation: キッセイ文化ホール(長野県)
  • Year and Date: 2012-11-08
• [Presentation] 温熱刺激による唾液腺アクアポリンと転写因子の発現調節 (2012)
  • Author(s): 杉本直俊、田中真生、澤木俊興、藤田義正、正木康史、梅原久範
  • Organizer: 第21回日本シェーグレン症候群学会学術集会
  • Place of Presentation: ウエスティン都ホテル京都(京都府)
  • Year and Date: 2012-09-07
• [Presentation] 温熱刺激による唾液腺房細胞アクアポリン5の発現調節 (2012)
  • Author(s): 杉本直俊、田中真生、澤木俊興、藤田義正、正木康史、梅原久範
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドホテル新高輪(東京都)
  • Year and Date: 2012-04-28
• [Presentation] 温熱刺激による唾液腺房細胞アクアポリン５の発現調節 (2012)
  • Author(s): 杉本直俊ほか
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドホテル新高輪（東京都）
• [Presentation] 温熱刺激による唾液腺アクアポリンと転写因子の発現調節 (2012)
  • Author(s): 杉本直俊ほか
  • Organizer: 第21回日本シェーグレン症候群学会学術集会
  • Place of Presentation: ウエスティン都ホテル京都（京都府）
• [Presentation] 短期～長期温熱刺激が細胞のheat toleranceへ与える影響 (2012)
  • Author(s): 杉本直俊ほか
  • Organizer: 第51回日本生気象学会大会
  • Place of Presentation: キッセイ文化ホール（長野県）
• [Presentation] ラット暑熱馴化形成時の唾液分泌機能変化 (2012)
  • Author(s): 松崎健太郎、杉本直俊ほか
  • Organizer: 第51回日本生気象学会大会
  • Place of Presentation: キッセイ文化ホール（長野県）
• [Presentation] 細胞から熱中症予防を考える
  • Author(s): 杉本直俊
  • Organizer: 第27回 運動と体温の研究会
  • Place of Presentation: 立教大学池袋キャンパス（東京）
• [Presentation] 高齢者の骨格筋の役割―体温調節と水分代謝の視点からの考察―
  • Author(s): 杉本直俊
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 日本教育会館・学術総合センター（東京）
  • Invited
• [Presentation] 熱耐性能獲得細胞からの熱中症予防関連分子の同定
  • Author(s): 杉本直俊、松崎健太郎、片倉賢紀、紫藤 治
  • Organizer: 第52回日本生気象学会大会
  • Place of Presentation: 米子市文化ホール（米子市）
• [Presentation] アミロイド-β脳室内投与によるラット行動性体温調節機能の変化
  • Author(s): 松崎健太郎、片倉賢紀、杉本直俊、宮本まゆみ、原俊子、紫藤治
  • Organizer: 第52回日本生気象学会大会
  • Place of Presentation: 米子市文化ホール（米子市）
• [Presentation] 食と若返り
  • Author(s): 杉本直俊
  • Organizer: 第一回「食と環境、そして高齢化を考える研究会」
  • Place of Presentation: ホテル日航金沢（金沢市）
  • Invited
• [Presentation] 低酸素環境下でのがん細胞の動向
  • Author(s): 杉本直俊、少作隆子、松崎健太郎、片倉賢紀、紫藤治
  • Organizer: 第 9回環境生理学プレコングス
  • Place of Presentation: レインボー桜島（鹿児島市）
• [Presentation] 杉本直俊ほか
  • Author(s): 培養細胞を用いた暑熱馴化の研究
  • Organizer: 第８回環境生理学プレコングレス
  • Place of Presentation: 東京女子医科大学・早稲田大卓連携 先端生命医科学研究教育施設（TWIns）（東京都）
• [Remarks]
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80272954