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Challenge to improve dry mouth through the TRP channel by spice

Research Project

Project/Area Number 24659105
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKanazawa University

Principal Investigator

SUGIMOTO Naotoshi  金沢大学, 医学系, 准教授 (80272954)

Co-Investigator(Kenkyū-buntansha) SHIDO Osamu  島根大学, 医学部, 教授 (40175386)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords香辛料 / 暑熱順化 / TRPチャネル / 環境 / 生理学
Research Abstract

We realize the greatness of saliva in the meal time. However, xerostomia which saliva secretion reduction is originating increases, and xerostomia serves as a big social problem in recent years. In addition, the current situation is that elder people are brought to increase, xerostomia of the elder people can not be ignored. We showed a possibility that a warming and spices could improve the QOL of mouth dryness through this research. And I proved not a little also about the molecular mechanism. I am sure that the result of this research contributes not only to elderly people but to people troubled with xerostomia.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (46 results)

All 2014 2013 2012 Other

All Journal Article (23 results) (of which Peer Reviewed: 22 results) Presentation (22 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] 3-Dimensional Tissue is Formed from Cancer Cells In Vitro on Gelfoam®, but not on MatrigelTM.2014

    • Author(s)
      Tome Y, Uehara F, Mii S, Yano S, Zhang L, Sugiomto N, Maehara H, Bouvet M, Tsutiya H, Kanaya F, Hoffman RM.
    • Journal Title

      J Cell Biochem.

      Volume: In press Issue: 8 Pages: 1362-1367

    • DOI

      10.1002/jcb.24780

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B2014

    • Author(s)
      Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A
    • Journal Title

      Nutr Cancer

      Volume: 66(3) Issue: 3 Pages: 419-23

    • DOI

      10.1080/01635581.2013.877497

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells2014

    • Author(s)
      Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
    • Journal Title

      Cell biochemistry and biophysics

      Volume: (in press) Issue: 1 Pages: 301-7

    • DOI

      10.1007/s12013-014-9912-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats2013

    • Author(s)
      Sugimoto N, Matsuzaki K, Ishibashi H, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Sekine J, Koizumi S, Yachie A, Umehara H and Shido O
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1763-1763

    • DOI

      10.1038/srep01763

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted activation of PKA and Epac promotes glioblastoma regression in vitro2013

    • Author(s)
      Sugimoto N, Miwa S, Tsuchiya H, Hitomi Y, Nakamura H, Yachie A, Koizumi S
    • Journal Title

      Mol Clin Oncol

      Volume: 1(2) Issue: 2 Pages: 281-285

    • DOI

      10.3892/mco.2013.65

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis.2013

    • Author(s)
      Ishikawa S, Shimizu M, Ueno K, Sugimoto N, Yachie A.
    • Journal Title

      Cytokine

      Volume: 62 Issue: 2 Pages: 272-277

    • DOI

      10.1016/j.cyto.2013.03.007

    • NAID

      130007956852

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time Imaging ofαv Integrin Molecular Dynamics in Osteosarcoma Cells In Vitro and In Vivo2013

    • Author(s)
      Tome Y, Sugimoto N, Yano S, Momiyama M, Mii S, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 3021-3025

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High Lung-metastatic Variant of Human Osteosarcoma Cells, Selected by Passage of Lung Metastasis in Nude Mice, Is Associated with Increased Expression ofαvβ3 Integrin2013

    • Author(s)
      Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 3623-3628

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy2013

    • Author(s)
      Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM
    • Journal Title

      J Cell Biochem

      Volume: 114(11) Issue: 11 Pages: 2454-60

    • DOI

      10.1002/jcb.24593

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus casei cell wall extract directly stimulates the expression of COX2 independent of Toll-like receptor 2 in rat glial cells2013

    • Author(s)
      Sugimoto N, Ohta K, Saito T, Nakayama Y, Nakamura T, Maeda A, Yachie A.
    • Journal Title

      J Microbiol Immunol Infect.

      Volume: 46 Issue: 5 Pages: 389-92

    • DOI

      10.1016/j.jmii.2012.03.004

    • NAID

      120004161555

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Real-time Imaging of αv Integrin Molecular Dynamics in Osteosarcoma Cells In Vitro and In Vivo.2013

    • Author(s)
      Tome Y, Sugimoto N, Yano S, Momiyama M, Mii S, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM.
    • Journal Title

      Anticancer Res.

      Volume: 33 Pages: 3021-3025

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Lung-metastatic Variant of Human Osteosarcoma Cells, Selected by Passage of Lung Metastasis in Nude Mice, Is Associated with Increased Expression of αvβ3 Integrin.2013

    • Author(s)
      Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM.
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 3623-3628

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration2012

    • Author(s)
      Suganuma S, Tada K, Hayashi K, Takeuchi A, Sugimoto N, Ikeda K, Tsuchiya H
    • Journal Title

      J Orthop Sci

      Volume: 18 Issue: 1 Pages: 145-51

    • DOI

      10.1007/s00776-012-0306-9

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells2012

    • Author(s)
      Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
    • Journal Title

      Cell Physiol Biochem.

      Volume: 30 Issue: 2 Pages: 450-457

    • DOI

      10.1159/000339038

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Skewed Production of IL-6 and TGFß by Cultured Salivary Gland Epithelial Cells from Patients with Sjögren's Syndrome2012

    • Author(s)
      Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Nakamura T, Sato T, Tanaka M, Masaki Y, Fukushima T, Hirose Y, Sugimoto N, Okazaki T, Umehara H
    • Journal Title

      Plos One

      Volume: 7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-κB and MAPK activations and cell proliferation through protein kinase A- or exchange protein activated by cAMP-dependent signal pathway2012

    • Author(s)
      Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomo Y, Nakamura H, Koizumi S, Yachie A
    • Journal Title

      ScientificWorldJournal

      Volume: 2012 Pages: 748572-748572

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87-MG human malignant glioma cells2012

    • Author(s)
      Echigo R, Sugimoto N, Yachie A
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 1176-1180

    • NAID

      120005285923

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caffeine Induces Apoptosis of Osteosarcoma Cells by Inhibiting AKT/mTOR/S6K, NF-κB and MAPK Pathways2012

    • Author(s)
      Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H
    • Journal Title

      Anticancer Res

      Volume: 23 Pages: 3643-3649

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptorαchain gene between atopic dermatitis and Japanese cedar pollinosis2012

    • Author(s)
      Tanaka T, HitomiY, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata A, Sugimoto N, Hatta K, Eboshida A, Konoshita T, Nakamura H
    • Journal Title

      Allergol Int

      Volume: 61 Pages: 57-63

    • NAID

      130004873044

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A-or Exchange Protein Activated by cAMP-Dependent Signal Pathway2012

    • Author(s)
      Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomi Y, Nakamura H, Koizumi S, Yachie A
    • Journal Title

      The Scientific World Journal

      Volume: 2012 Pages: 748572-748572

    • DOI

      10.1100/2012/748572

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells2012

    • Author(s)
      Ryosuke Echigo
    • Journal Title

      Oncology Reports

      Volume: 28 Issue: 4 Pages: 1176-1180

    • DOI

      10.3892/or.2012.1937

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways.2012

    • Author(s)
      Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H.
    • Journal Title

      Anticancer Res.

      Volume: 32 Pages: 3643-3649

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Skewed production of IL-6 and TGFbeta by cultured salivary gland epithelial cells from patients with Sjogren's syndrome2012

    • Author(s)
      Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Nakamura T, Sato T, Fujita Y, Tanaka M, Masaki Y, Fukushima T, Hirose Y, Taniguchi M, Sugimoto N, Okazaki T and Umehara H
    • Journal Title

      PLoS One

      Volume: 7 Issue: 10 Pages: e45689-e45689

    • DOI

      10.1371/journal.pone.0045689

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 低酸素環境下でのがん細胞の動向2014

    • Author(s)
      杉本直俊、少作隆子、松崎健太郎、片倉賢紀、紫藤治
    • Organizer
      第9回環境生理学プレコングス
    • Place of Presentation
      国民宿舎レインボー桜島(鹿児島県)
    • Year and Date
      2014-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 食と若返り2013

    • Author(s)
      杉本直俊
    • Organizer
      第一回食と環境、そして高齢化を考える研究会
    • Place of Presentation
      ホテル日航金沢(石川県)
    • Year and Date
      2013-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 熱耐性能獲得細胞からの熱中症予防関連分子の同定2013

    • Author(s)
      杉本直俊、松崎健太郎、片倉賢紀、紫藤治
    • Organizer
      第52回日本生気象学会大会
    • Place of Presentation
      米子市文化ホール(鳥取県)
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] アミロイド-β脳室内投与によるラット行動性体温調節機能の変化2013

    • Author(s)
      松崎健太郎、片倉賢紀、杉本直俊、宮本まゆみ、原俊子、紫藤治
    • Organizer
      第52回日本生気象学会大会
    • Place of Presentation
      米子市文化ホール(鳥取県)
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢者の骨格筋の役割―体温調節と水分代謝の視点からの考察―2013

    • Author(s)
      杉本直俊
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      日本教育会館・学術総合センター(東京都)
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞から熱中症予防を考える2013

    • Author(s)
      杉本直俊
    • Organizer
      第27回運動と体温の研究会
    • Place of Presentation
      立教大学池袋キャンパス(東京都)
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 培養細胞を用いた暑熱馴化の研究2013

    • Author(s)
      杉本直俊、松崎健太郎、紫藤治
    • Organizer
      第8回環境生理学プレコングレス
    • Place of Presentation
      東京女子医科大学・早稲田大卓連携先端生命医科学研究教育施設(TWIns)(東京都)
    • Year and Date
      2013-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット暑熱馴化形成時の唾液分泌機能変化2012

    • Author(s)
      松崎健太郎、杉本直俊、宮本まゆみ、原俊子、紫藤治
    • Place of Presentation
      キッセイ文化ホール(長野県)
    • Year and Date
      2012-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 短期~長期温熱刺激が細胞のheat toleranceへ与える影響2012

    • Author(s)
      杉本直俊、松崎健太郎、紫藤治
    • Organizer
      第51回日本生気象学会大会
    • Place of Presentation
      キッセイ文化ホール(長野県)
    • Year and Date
      2012-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 温熱刺激による唾液腺アクアポリンと転写因子の発現調節2012

    • Author(s)
      杉本直俊、田中真生、澤木俊興、藤田義正、正木康史、梅原久範
    • Organizer
      第21回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      ウエスティン都ホテル京都(京都府)
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 温熱刺激による唾液腺房細胞アクアポリン5の発現調節2012

    • Author(s)
      杉本直俊、田中真生、澤木俊興、藤田義正、正木康史、梅原久範
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドホテル新高輪(東京都)
    • Year and Date
      2012-04-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 温熱刺激による唾液腺房細胞アクアポリン5の発現調節2012

    • Author(s)
      杉本直俊ほか
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドホテル新高輪(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 温熱刺激による唾液腺アクアポリンと転写因子の発現調節2012

    • Author(s)
      杉本直俊ほか
    • Organizer
      第21回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      ウエスティン都ホテル京都(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] 短期~長期温熱刺激が細胞のheat toleranceへ与える影響2012

    • Author(s)
      杉本直俊ほか
    • Organizer
      第51回日本生気象学会大会
    • Place of Presentation
      キッセイ文化ホール(長野県)
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット暑熱馴化形成時の唾液分泌機能変化2012

    • Author(s)
      松崎健太郎、杉本直俊ほか
    • Organizer
      第51回日本生気象学会大会
    • Place of Presentation
      キッセイ文化ホール(長野県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞から熱中症予防を考える

    • Author(s)
      杉本直俊
    • Organizer
      第27回 運動と体温の研究会
    • Place of Presentation
      立教大学池袋キャンパス(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高齢者の骨格筋の役割―体温調節と水分代謝の視点からの考察―

    • Author(s)
      杉本直俊
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      日本教育会館・学術総合センター(東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 熱耐性能獲得細胞からの熱中症予防関連分子の同定

    • Author(s)
      杉本直俊、松崎健太郎、片倉賢紀、紫藤 治
    • Organizer
      第52回日本生気象学会大会
    • Place of Presentation
      米子市文化ホール(米子市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アミロイド-β脳室内投与によるラット行動性体温調節機能の変化

    • Author(s)
      松崎健太郎、片倉賢紀、杉本直俊、宮本まゆみ、原俊子、紫藤治
    • Organizer
      第52回日本生気象学会大会
    • Place of Presentation
      米子市文化ホール(米子市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食と若返り

    • Author(s)
      杉本直俊
    • Organizer
      第一回「食と環境、そして高齢化を考える研究会」
    • Place of Presentation
      ホテル日航金沢(金沢市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 低酸素環境下でのがん細胞の動向

    • Author(s)
      杉本直俊、少作隆子、松崎健太郎、片倉賢紀、紫藤治
    • Organizer
      第 9回環境生理学プレコングス
    • Place of Presentation
      レインボー桜島(鹿児島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 杉本直俊ほか

    • Author(s)
      培養細胞を用いた暑熱馴化の研究
    • Organizer
      第8回環境生理学プレコングレス
    • Place of Presentation
      東京女子医科大学・早稲田大卓連携 先端生命医科学研究教育施設(TWIns)(東京都)
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80272954

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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