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Analysis of mechanisms underlying strain recognition memory in mice using visualization techniques

Research Project

Project/Area Number 24659108
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKochi University

Principal Investigator

KABA Hideto  高知大学, 教育研究部医療学系, 教授 (50136371)

Co-Investigator(Kenkyū-buntansha) OKUTANI Fumino  高知大学, 教育研究部医療学系, 准教授 (10194490)
TANIGUCHI Mutsuo  高知大学, 教育研究部医療学系, 助教 (10304677)
MURATA Yoshihiro  高知大学, 教育研究部医療学系, 助教 (40377031)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords匂い / 記憶 / 副嗅球 / 可視化 / 発火パターン / 代謝型グルタミン酸受容体 / Ca2+チャネル / バゾプレッシン / ドキシサイクリン / c-fosプロモーター / フェロモン / 交尾 / 僧帽細胞 / 顆粒細胞
Research Abstract

By using transgenic mice that stably express the green fluorescent protein (GFP) coupled to the activity-dependent gene c-fos in mitral and granule cells naturally activated by the association of mating male chemosignals and mating signal in the accessory olfactory bulb (AOB), we found in AOB slices that GFP-positive mitral cells fired in burst mode in contrast to GFP-negative mitral cells that fired in tonic mode. In addition, we found in AOB slices prepared from normal mice that the activation of mGluR2 on mitral cells in the AOB inhibited voltage-dependent Ca2+ channels, thereby suppressing the release of glutamate from the mitral cells and that vasopressin that enhances the induction of long-term potentiation at the mitral-to-granule cell synapse in the AOB reduced dendrodendritic inhibition of mitral cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (12 results) (of which Invited: 2 results) Book (3 results) Remarks (1 results)

  • [Journal Article] 社会的絆を支える匂いの記憶・学習のメカニズム2013

    • Author(s)
      椛秀人
    • Journal Title

      分子精神医学

      Volume: 13 Pages: 260-266

    • URL

      http://www.sentan.com

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Regulation of synaptic cur rents by mGluR2 at reciprocal syna pses in the mouse accessory olfact ory bulb2013

    • Author(s)
      Taniguchi M, Yokoi M, Shinohara Y, Okutani F, Murata Y, Nakanishi S, Kaba H
    • Journal Title

      European Journal of Neur oscience

      Volume: 37 Issue: 3 Pages: 351-358

    • DOI

      10.1111/ejn.12059

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 嗅覚2013

    • Author(s)
      椛秀人
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 70-72

    • URL

      http://chugaiigaku.jp/

    • Related Report
      2013 Final Research Report
  • [Journal Article] Neurobiology of secure infant attachm ent and attachment despite adversit y : a mouse model2013

    • Author(s)
      Roth TL, Raineki C, Salstein L, Perr y R, Sullivan-Wilson TA, Sloan A, La lji B, Hammock E, Wilson DA, Levitt P, Okutani F, Kaba H, Sullivan RM
    • Journal Title

      Genes Brain and Behavior

      Volume: 12 Issue: 7 Pages: 673-680

    • DOI

      10.1111/gbb.12067

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス副嗅球僧帽細胞—顆粒細胞間相反性シナプス伝達に対するバゾプレッシンの効果2014

    • Author(s)
      谷口睦男,難波利治,椛秀人
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス,鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] オスマウス副嗅球におけるシナプス可塑性に対するバゾプレッシンの役割2014

    • Author(s)
      難波利治,谷口睦男,村田芳博,奥谷文乃,椛秀人
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス,鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス副嗅球シナプスの長期増強におけるアクチン重合化の関与2014

    • Author(s)
      村田芳博,椛秀人
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス,鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] フェロモン記憶と個体認知2013

    • Author(s)
      椛秀人,藤田博子,吾妻健,奥谷文乃,松波宏明
    • Organizer
      日本味と匂学会第47回大会嗅覚シンポジウム「化学シグナルと嗅覚行動および脳機能」
    • Place of Presentation
      仙台市民会館,仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 感受性期に成立する匂い学習の神経生物学2013

    • Author(s)
      椛秀人
    • Organizer
      日本味と匂学会第47回大会日本味と匂学会賞受賞講演
    • Place of Presentation
      仙台市民会館,仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] フェロモン記憶と個体認知2013

    • Author(s)
      椛 秀人, 藤田博子, 吾妻 健, 奥谷文乃, 松波宏明
    • Organizer
      日本味と匂学会第47回大会
    • Place of Presentation
      仙台市民会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 感受性期に成立する匂い学習の神経生物学2013

    • Author(s)
      椛 秀人
    • Organizer
      日本味と匂学会第47回大会
    • Place of Presentation
      仙台市民会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A suppressing mechanism of the recurrent inhibi tion by group II metabotropic glut amate receptors activated by endog enous glutamate release from mitra l cells in the mouse accessory olf actory bulb2012

    • Author(s)
      Taniguchi M, Kaba H
    • Organizer
      XVI International Sym posium on Olfaction and Taste
    • Place of Presentation
      Stockholm Waterfron t, Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Mat ernally inherited peptides functio n as strain identity chemosignals in mice2012

    • Author(s)
      Kaba H, Fujita H, Matsunami H
    • Organizer
      XVI International Symposi um on Olfaction and Taste
    • Place of Presentation
      Stockholm Waterfron t, Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] A functional rol e for protein synthesis in long-te rm potentiation at synapses in the mouse accessory olfactory bulb2012

    • Author(s)
      Murata Y, Kaba H
    • Organizer
      X VI International Symposium on Olfa ction and Taste
    • Place of Presentation
      Stockholm Waterfron t, Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Vasopressin serve s to promote the induction of syna ptic plasticity in the mouse acces sory olfactory bulb2012

    • Author(s)
      Namba T, Taniguchi M, Murata Y, Ok utani F, Kaba H
    • Organizer
      XVI Internati onal Symposium on Olfaction and Ta ste
    • Place of Presentation
      Stockholm Waterfron t, Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Maternally inherited peptides function as strain identity chemosignals in mice.2012

    • Author(s)
      Kaba H
    • Organizer
      XVI International Symposium on Olfaction and Taste
    • Place of Presentation
      Radisson Blu Waterfront hotel (Sweden)
    • Related Report
      2012 Research-status Report
  • [Book] 脳神経科学イラストレイテッドー分子・細胞から実験技術まで2013

    • Author(s)
      椛秀人
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] 脳神経科学イラストレイテッドー分子・細胞から実験技術まで2013

    • Author(s)
      椛 秀人
    • Total Pages
      395
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 解剖生理学〔第2版〕2012

    • Author(s)
      椛秀人
    • Publisher
      化学同人
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.kochi-ms.ac.jp/~ff_phsl1/index.htm

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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