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Neural mechanisms for social behavior: roles of neurohypophyseal hormones

Research Project

Project/Area Number 24659110
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionJichi Medical University

Principal Investigator

ONAKA Tatsushi  自治医科大学, 医学部, 教授 (90177254)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords下垂体後葉ホルモン / バゾプレシン / オキシトシン
Research Abstract

Oxytocin-oxytocin receptor systems play important roles in the control of social behaviors. Oxytocin-synthesizing neurons are localized not only in the hypothalamus but also in the bed nucleus of stria termninalis. However, it is not clear which oxytocin-synthesizing neurons are involved in social behaviors. On the other hand, oxytocin receptors can be activated by oxytocin and vasopressin. We tried to establish a method for destroying local oxytocin- or vasopressin-synthesizing neurons. We successfully destroyed vasopressin-synthesizing neurons in the olfactory bulb.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 4 results) Presentation (13 results) (of which Invited: 2 results)

  • [Journal Article] ストレス・摂食・社会行動の相互作用 : オキシトシンの働き2014

    • Author(s)
      尾仲達史
    • Journal Title

      心身医学

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
  • [Journal Article] オキシトシンの働きと老化2014

    • Author(s)
      尾仲達史
    • Journal Title

      最新医学

      Volume: 69巻, 5号 Pages: 1021-1031

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] ストレス・摂食・社会行動の相互作用:オキシトシンの働き2014

    • Author(s)
      尾仲達史
    • Journal Title

      心身医学

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake.2013

    • Author(s)
      Yamashita,M., Takayanagi,Y., Yoshida,M., Nishimori,K., Kusama, M. and Onaka,T.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 25 Issue: 5 Pages: 455-465

    • DOI

      10.1111/jne.12019

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ストレスと摂食2013

    • Author(s)
      尾仲達史
    • Journal Title

      ストレスアンドヘルスケア

      Volume: 210巻 Pages: 1-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] 母性行動と下垂体ホルモン2013

    • Author(s)
      尾仲達史,高柳友紀
    • Journal Title

      精神科治療学

      Volume: 28巻, 6号 Pages: 777-784

    • Related Report
      2013 Final Research Report
  • [Journal Article] Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour2012

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Journal Title

      J Neuroendocrinol

      Volume: 24 Issue: 4 Pages: 587-598

    • DOI

      10.1111/j.1365-2826.2012.02300.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of exocytosis proteins in rat supraoptic nucleus neurones2012

    • Author(s)
      Tobin V, Schwab Y, Lelos N, Onaka T, Pittman QJ, Ludwig M
    • Journal Title

      J Neuroendocrinol

      Volume: 24 Issue: 4 Pages: 629-641

    • DOI

      10.1111/j.1365-2826.2011.02237.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] オキシトシン・バゾプレシンの働きについて2012

    • Author(s)
      尾仲達史
    • Journal Title

      ベビーサイエンス

      Volume: 12巻 Pages: 13-15

    • Related Report
      2013 Final Research Report
  • [Journal Article] オキシトシンとストレス緩和作用2012

    • Author(s)
      尾仲達史,高柳友紀,吉田匡秀
    • Journal Title

      Clinical Neuroscience

      Volume: 30巻, 2号 Pages: 212-215

    • Related Report
      2013 Final Research Report
  • [Journal Article] プロラクチン放出ペプチド(PrRP)2012

    • Author(s)
      高柳友紀,尾仲達史
    • Journal Title

      Clinical Neuroscience

      Volume: 30巻, 2号 Pages: 176-177

    • Related Report
      2013 Final Research Report
  • [Journal Article] The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents

    • Author(s)
      Yoshida M, Takayanagi Y, Onaka T
    • Journal Title

      Endocrinology

      Volume: (In press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 社会的記憶の制御におけるセクレチンーオキシトシンシステムの役割2014

    • Author(s)
      高柳友紀,尾仲達史
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 心身ストレスとその機序2013

    • Author(s)
      尾仲達史
    • Organizer
      生体機能の理解にもとづく災害ストレス支援の推進事業第1回シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動2013

    • Author(s)
      尾仲達史,高柳友紀,吉田匡秀
    • Organizer
      創薬薬理フォーラム第21回シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress and energy metabolisms : roles of PrRP and oxytocin2013

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Organizer
      The 36^<th> Naito Conference on"Molecular Aspects of Energy Balance and Feeding Behavior"
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] ストレス,摂食そして社会行動 : 最近注目されるオキシトシンの働き2013

    • Author(s)
      尾仲達史
    • Organizer
      第54回日本心身医学会総会ならびに学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 恐怖記憶の想起による神経内分泌反応には内側扁桃体—延髄PrRP産生ニューロン経路が関与する2013

    • Author(s)
      吉田匡秀,高柳友紀,尾仲達史
    • Organizer
      第36回日本神経科学大会(Neuro2013)
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] ストレス,摂食そして社会行動:最近注目されるオキシトシンの働き2013

    • Author(s)
      尾仲達史
    • Organizer
      第54回日本心身医学会総会ならびに学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動2013

    • Author(s)
      尾仲達史、高柳友紀、吉田匡秀
    • Organizer
      創薬薬理フォーラム第21回シンポジウム
    • Place of Presentation
      日本薬学会長井記念館(東京都渋谷区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エネルギー代謝とストレスにおけるPrRP-オキシトシン系の働き2012

    • Author(s)
      高柳友紀,山下雅子,草間幹夫,尾仲達史
    • Organizer
      第39回日本神経内分泌学会学術集会
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] PrRP-オキシトシン系による摂食調節2012

    • Author(s)
      高柳友紀,山下雅子,草間幹夫,尾仲達史
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] 摂食とストレスと社会記憶におけるオキシトシンの働き2012

    • Author(s)
      尾仲達史,高柳友紀,吉田匡秀
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Related Report
      2013 Final Research Report
  • [Presentation] オキシトシンとストレス・摂食・社会行動2012

    • Author(s)
      尾仲達史
    • Organizer
      第2回金沢大学子どものこころサミット
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of oxytocin and vasopressin in the control of social behavior2012

    • Author(s)
      Onaka T
    • Organizer
      Satellite symposium of the 7^<th> Asia and Oceania Society for Comparative Endocrinology (AOSCE) Congress
    • Place of Presentation
      Penang, Malaysia
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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