Endothelial microparticles modulate cellular status of pericytes
| Project/Area Number |
24659112
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
YAMAMOTO Seiji 富山大学, 医学薬学研究部(医学), 助教 (10456361)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | EMP / Endothelial cells / Pericytes / 血管内皮細胞 / 炎症 |
|---|
| Research Abstract |
We studied endothelial microparticles (EMPs) produced from inflamed endothelial cells in vitro. EMPs incorporation study was performed, and mRNA and protein expression levels were analyzed using pericytes by the action of the EMPs. Here we show that EMPs contained inflammatory specific miRNA. EMPs incorporated pericytes were altered their transcription and protein expression levels. We have shown that target cells of EMPs are pericytes, suggesting EMPs and miRNA included in the EMPs are new therapeutic target of the various inflammatory diseases.
|
Report
(3 results)
Research Products
(28 results)
-
[Journal Article] PDGFR-βas a positive regulator of tissue repair in a mouse model of focal cerebral ischemia2012
Author(s)
Shen J, IshiiY, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M
-
Journal Title
J Cereb Blood Flow Metabol
Volume: 32
Pages: 353-367
Related Report
Peer Reviewed
-
[Journal Article] Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity2012
Author(s)
Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K
-
Journal Title
J Immunol
Volume: 188
Pages: 703-713
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Endothelial microparticles (EMPs)由来miRNAの機能解析2012
Author(s)
山本誠士,東英梨月,村松昌,柳橋努,生谷尚士,長井良憲,高津聖志,堂本光子,松田直之,新飯田俊平,服部裕一
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡(2P-0355)
Year and Date
2012-12-12
Related Report
-
-
[Presentation] Functional analysis of miRNA contained in the endothelial microparticles (EMPs)2012
Author(s)
Yamamoto S, Azuma E, Muramatsu M, Yanagibashi T, Ikutani M, Nagai Y, Takatsu K, Dohmoto M, Matsuda N, Niida S, Hattori Y
Organizer
The 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization
Place of Presentation
Tokushima(O-37)
Year and Date
2012-12-07
Related Report
-
-
-
[Presentation] Inflammatory endothelial microparticles (EMPs) contribute to cellular interaction as a bioactive carrier2012
Author(s)
Yamamoto S, Azuma E, Yanagibashi T, Ikutani M, Nagai Y, Takatsu K, Miyazaki K, Dohmoto M, Muramatsu M, Matsuda N, Niida S, Hattori Y
Organizer
The 17th International Vascular Biology Meeting
Place of Presentation
Wiesbaden, Germany(PII-34)
Year and Date
2012-06-03
Related Report
-
-
-
-
-
-
-
-
-
