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Lymphangiogenesis as a regulator of fluid homeostasis in pathological settings

Research Project

Project/Area Number 24659119
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General pharmacology
Research InstitutionKitasato University

Principal Investigator

MAJIMA Masataka  北里大学, 医学部, 教授 (70181641)

Co-Investigator(Kenkyū-buntansha) KITASATO Hidero  北里大学, 医療衛生学部, 教授 (90195256)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsプロスタノイド / リンパ管新生 / ホメオスタシス / 体液 / 高血圧 / 炎症 / LPS / COX-2 / 腹水 / アラキドン酸代謝物 / COX / PGE合成酵素 / 皮下組織 / ナトリウム / Lyve-1 / VEGF-C / 食塩
Outline of Final Research Achievements

We had tested the roles of an inducible prostaglandin E synthase, mPGES-1 in facilitation of inflammation-induced lymphangiogenesis (IL) elicited by lipopollysccharide (LPS). With LPS i.p. injections, lymphatics in diaphragm were widened and Lyve-1-positive ladder-structured lymphatics were increased temporally in comparison with vehicle-treated wild type mice (WT). This increase of lymphangiogenesis was accompanied with increased expressions of vascular endothelial growth factor (VEGF)-C/D. In mPGES-1 knockout mice (KO), IL was suppressed with reduced expressions of VEGF-C/D. When FITC-dextran was injected into peritoneal cavities, the residual amount of FITC-dextran was reduced significantly in WT with LPS treatment. This reduction was significantly restored in mPGES-1 KO. These results suggested that mPGES-1 had significant roles in facilitation of lymphangiogenesis active in fluid drainage during IL, and that this enzyme will be a novel target for controlling IL.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (35 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (13 results) (of which Invited: 13 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Suppressed recruitment of alternatively activated macrophages reduces TGF-β1 and impairs wound healing in streptozotocin-induced diabetic mice.2015

    • Author(s)
      Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Amano H, Shichiri M, Majima M.
    • Journal Title

      Biomed Pharmacother.

      Volume: 70 Pages: 317-325

    • DOI

      10.1016/j.biopha.2014.10.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of cyclooxygenase-2 in the development of interstitial fibrosis in kidneys following unilateral ureteral obstruction in mice2015

    • Author(s)
      Kamata M, Hosono K, Fujita T, Kamata K, Majima M.
    • Journal Title

      Biomed Pharmacother.

      Volume: 70 Pages: 174-180

    • DOI

      10.1016/j.biopha.2015.01.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepaticischemia/reperfusion injury.2014

    • Author(s)
      Ohkubo H, Ito Y, Minamino T, Eshima K, Kojo K, Okizaki S, Hirata M, Shibuya M, Watanabe M, Majima M.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e105533-e105533

    • DOI

      10.1371/journal.pone.0105533

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostanoid induces premetastatic niche in regional lymph nodes.2014

    • Author(s)
      Ogawa F, Amano H, Eshima Y, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiiya S, Majima M.
    • Journal Title

      J. Clin. Invest.

      Volume: 124 Issue: 11 Pages: 4882-4894

    • DOI

      10.1172/jci73530

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Downregulation of the proangiogenic prostaglandin E receptor EP3 and reduced angiogenesis in a mouse model of diabetes mellitus.2014

    • Author(s)
      Oba K, Hosono K, Amano H, Okizaki S, Ito Y, Shichiri M, Majima M.
    • Journal Title

      Biomed Pharmacother.

      Volume: 68 Issue: 8 Pages: 1125-1133

    • DOI

      10.1016/j.biopha.2014.10.022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy.2014

    • Author(s)
      Matsui Y, Amano H, Ito Y, Eshima K, Tamaki H, Ogawa F, Iyoda A, Shibuya M, Kumagai Y, Satoh Y, Majima M.
    • Journal Title

      Laboratory Investigation.

      Volume: 201 Pages: 1-10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells.2014

    • Author(s)
      Takahashi R., Amano H., Satoh T., Tabata K., Ikeda M., Kitasato H., Akira S., Iwamura M., Majima M.
    • Journal Title

      Biomed Pharmacother.

      Volume: 68 Issue: 1 Pages: 71-77

    • DOI

      10.1016/j.biopha.2013.10.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells.2014

    • Author(s)
      Takahashi R., Amano H., Satoh T., Tabata K., Ikeda M., Kitasato H., Akira S., Iwamura M., Majima M.
    • Journal Title

      Biomed Pharmacother.

      Volume: 28 Issue: 3 Pages: 1237-1247

    • DOI

      10.1096/fj.13-238998

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aspirin reduces lung cancer metastasis to regional lymph nodes.2014

    • Author(s)
      Ogawa F., Amano H., Ito H., Matsui Y., Hosono K., Kitasato H., Satoh Y., Majima M.
    • Journal Title

      Biomed Pharmacother.

      Volume: 68 Issue: 1 Pages: 79-86

    • DOI

      10.1016/j.biopha.2013.11.006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment.2013

    • Author(s)
      Ohkubo H., Ito Y., Minamino T., Mishima T., Hirata M., Hosono K., Shibuya M., Yokomizo T., Shimizu T., Watanabe M., Majima M.
    • Journal Title

      FASEB J.

      Volume: 27 Issue: 8 Pages: 3132-3143

    • DOI

      10.1096/fj.13-227421

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the up regulation of epidermal growth factor expression on VEGFR1+ CXCR4+ cells recruited from bone marrow.2013

    • Author(s)
      Sato T., Amano H., Ito Y., Eshima K., Minamino T., Ae T., Katada C., Ohno T., Hosono K., Suzuki T., Shibuya M., Koizumi W., Majima M.
    • Journal Title

      J Gastroenterol.

      Volume: 49 Issue: 3 Pages: 455-469

    • DOI

      10.1007/s00535-013-0869-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells2013

    • Author(s)
      Amano H, Ito Y, Ogawa F, Eshima K, Suzuki T, Oba K, Matsui Y, Kato S, Fukui T, Nakamura M, Kitasato H, Fukamizu A, Majima M
    • Journal Title

      Am J Pathol

      Volume: 182(2) Issue: 2 Pages: 553-64

    • DOI

      10.1016/j.ajpath.2012.10.026

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model2012

    • Author(s)
      Nakamura M, Tsumura H, Satoh T, Matsumoto K, Maruyama H, Majima M, Kitasato H
    • Journal Title

      Biomed Pharmacother

      Volume: 67(1) Issue: 1 Pages: 66-71

    • DOI

      10.1016/j.biopha.2012.10.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thromboxane A_2 receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells2012

    • Author(s)
      Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S, Nakamura M, Kitasato H, Narumiya S, Majima M
    • Journal Title

      Cancer Sci

      Volume: 103(4) Issue: 4 Pages: 700-7

    • DOI

      10.1111/j.1349-7006.2012.02200.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment2012

    • Author(s)
      Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H, Narumiya S, Koizumi W, Majima M
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 259(1) Issue: 1 Pages: 104-14

    • DOI

      10.1016/j.taap.2011.12.013

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats2011

    • Author(s)
      Fujita T, Ishihara K, Yasuda S, Nakamura T, Maeda M, Kobayashi M, Sahashi K, Ikeda Y, Kumagai Y, Majima M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 341(3) Issue: 3 Pages: 626-33

    • DOI

      10.1124/jpet.111.187732

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Roles of prostaglandins in regulation of plasticity of lymphatics and lymph nodes2015

    • Author(s)
      Masataka Majima
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (Symposium)
    • Place of Presentation
      Keio Plaza Hotel (Shinjuku,Tokyo)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Roles of Arachidonic Acid Metabolites in Angiogenesis2014

    • Author(s)
      Masataka Majima
    • Organizer
      Gordon Research Conference; Endothelial Cell Phenotypes in Health & Disease
    • Place of Presentation
      Girona, Spain
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Roles of prostanoids in regulation of angiogenesis and lymphagiogenesis2014

    • Author(s)
      Masataka Majima
    • Organizer
      Research Forum on Cancer Biology in Moses Cancer Center
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Prostanoids as Regulators of Pathological Lymphangiogenesis2014

    • Author(s)
      Majima M., Hosono K., Amano H., Ogawa F., Park K.
    • Organizer
      GRC Molecular Mechanisms in Lymphatic Function & Disease
    • Place of Presentation
      Barga (Italy)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 病態時のリンパ管新生とリンパ流を制御するプロスタグランジンの役割2013

    • Author(s)
      馬嶋正隆
    • Organizer
      第37回日本リンパ学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Roles of Prostanoids in Pathological Lymphangiogenesis2013

    • Author(s)
      馬嶋正隆
    • Organizer
      第3回リンパ学に関する松本カンファランス
    • Place of Presentation
      松本
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Prostanoids regulate tumor stromal profiles via specific G-protein coupled receptors2013

    • Author(s)
      Majima M., Hosono K., Suzuki T., Amano H., Kato H., Ogawa F., Park K.
    • Organizer
      4th International conference on tumor-host interaction and Angiogenesis
    • Place of Presentation
      Ascona (Switzerland)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Microsomal prostaglandin E synthase-1 as a regulator of angiogenesis2013

    • Author(s)
      Majima M., Hosono K., Suzuki T., Amano H.
    • Organizer
      GRC Angiogenesis
    • Place of Presentation
      New Port (United States)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis during the developments of cancers and inflammation.2012

    • Author(s)
      Majima M.
    • Organizer
      Keystone Symposium: Inflammation during Carcinogenesis
    • Place of Presentation
      Dublin (アイルランド)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Roles of thromboxane receptor signaling in enhancement of angiogenesis.2012

    • Author(s)
      Majima M.
    • Organizer
      17th International Vascular Biology Meeting (IVBM) 2012
    • Place of Presentation
      Wiesbaden(ドイツ)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 病態時の脈管新生を制御する脂質メディエーターの役割2012

    • Author(s)
      馬嶋正隆
    • Organizer
      千里ライフサイエンスセミナー D5 脂質メディエーターと疾患
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ショック研究における基礎医学と臨床医学の連携2012

    • Author(s)
      馬嶋正隆
    • Organizer
      第27回日本Shock学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis in diseases.2012

    • Author(s)
      Majima M.
    • Organizer
      1st International Symposium on Lipid Mediators
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 標準薬理学第7版2015

    • Author(s)
      馬嶋正隆、監修今井正、編集飯野正光
    • Total Pages
      674
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 遺伝子医学MOOK 24号 最新生理活性脂質研究-実験手法、基礎的知識とその応用-2013

    • Author(s)
      馬嶋正隆、青木淳賢、杉本幸彦、村上誠、横溝岳彦(監修) 他
    • Total Pages
      312
    • Publisher
      メディカル ドゥ社
    • Related Report
      2013 Research-status Report
  • [Book] 「最新生理活性脂質研究-実験手法、基礎的知識とその応用-」遺伝子医学MOOK 24号2013

    • Author(s)
      馬嶋正隆
    • Publisher
      メディカル ドゥ社
    • Related Report
      2012 Research-status Report
  • [Book] 医学書院2013

    • Author(s)
      馬嶋正隆
    • Publisher
      標準薬理学 第7版
    • Related Report
      2012 Research-status Report
  • [Remarks] 北里大学医学部薬理学単位ホームページ

    • URL

      http://www.med.kitasato-u.ac.jp/pharm/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 北里大学医学部薬理学・大学院医療系研究科分子薬理学

    • URL

      http://www.med.kitasato-u.ac.jp/pharm/

    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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