Identification of phosphatidylglycerophosphate-binding proteins.

• Project/Area Number: 24659124
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Akita University
• Principal Investigator: TAKASUGA SHUNSUKE 秋田大学, 医学(系)研究科(研究院), 助教 (90375262)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 細胞内シグナル伝達 / リン脂質 / ミトコンドリア

Research Abstract

Phosphatidylglycerophosphate (PGP) is a mitochondrial glycerophospholipid, known as a precursor of cardiolipin. We tried to identify PGP-binding proteins in mitochondria for elucidation of unique physiological functions of PGP. However, none of mitochondrial proteins containing known phospholipid binding domains binds PGP. Therefore, PGP-binding proteins might have a novel lipid-binding domain.

Research Products

• [Journal Article] Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions. (2013)
  • Author(s): Takasuga S. and Sasaki T.
  • Journal Title: J. Biochem. Volume: 154 Issue: 3 Pages: 211-218
  • DOI: 10.1093/jb/mvt064
  • NAID: 40019769805
  • Peer Reviewed
• [Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine (2012)
  • Author(s): Takasuga , Wada et al.
  • Journal Title: PNAS 110 Volume: 1726-1731 Issue: 5 Pages: 1726-31
  • DOI: 10.1073/pnas.1213212110
  • Peer Reviewed
• [Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics (2012)
  • Author(s): Hazeki K.
  • Journal Title: FEBS Lett Volume: 586 Issue: 22 Pages: 4010-4015
  • DOI: 10.1016/j.febslet.2012.09.043
  • Peer Reviewed
• [Journal Article] Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos (2012)
  • Author(s): Kawamura, Wada et al.
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1071-1071
  • DOI: 10.1038/ncomms2069
  • Peer Reviewed
• [Journal Article] 3′ Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P ₂] by voltage-sensing phosphatase (VSP) (2012)
  • Author(s): Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T & Okamura Y
  • Journal Title: VSP. Proc. Natl. Acad. Sci. U.S.A. Volume: 109 Issue: 25 Pages: 10089
  • DOI: 10.1073/pnas.1203799109
  • Peer Reviewed
• [Presentation] ホスファチジルグリセロールリン酸(PGP)ホスファターゼの生理機能 (2013)
  • Author(s): 高須賀俊輔、浅沼研、木村洋貴、高須賀緑、中西広樹、佐々木純子、山崎正和、妹尾春樹、佐々木雄彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2013-09-11
• [Presentation] ホスファチジルグリセロールリン酸（PGP）ホスファターゼの生理機能
  • Author(s): 高須賀俊輔、浅沼研、木村洋貴、高須賀緑、中西広樹、佐々木純子、山崎正和、妹尾春樹、佐々木雄彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜（横浜市）