| Project/Area Number |
24659126
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
INOUE Satoshi 東京大学, 医学部附属病院, 特任教授 (40251251)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ビタミンK / γカルボキシラーゼ / ステロイドX受容体 / プレグナンX受容体 / 核内受容体 / γカルボキシナーゼ |
|---|
| Research Abstract |
Vitamin K is a fat-soluble vitamin that has multiple roles in blood coagulation, bone, joint, brain and so on. Vitamin K is a cofactor of gamma-glutamyl carboxylase (GGCX) that modulates substrates such as hepatic blood coagulation factors by carboxylation. Moreover, vitamin K also activates nuclear receptor SXR/PXR as a ligand. We generated conditional GGCX and PXR knockout mice to study the physiological and pathopysiological roles of vitamin K. PXR knockout mice displayed osteopenia. Liver-specific Ggcx knockout mice display short life span due to hemorrhage. Using these animal models we can study differential roles and mechanisms of vitamin K action.
|
