Roles of vitamin K action through the protein modification and transcriptional activation via the nuclear receptor
| Project/Area Number |
24659126
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
INOUE Satoshi 東京大学, 医学部附属病院, 特任教授 (40251251)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ビタミンK / γカルボキシラーゼ / ステロイドX受容体 / プレグナンX受容体 / 核内受容体 / γカルボキシナーゼ |
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| Research Abstract |
Vitamin K is a fat-soluble vitamin that has multiple roles in blood coagulation, bone, joint, brain and so on. Vitamin K is a cofactor of gamma-glutamyl carboxylase (GGCX) that modulates substrates such as hepatic blood coagulation factors by carboxylation. Moreover, vitamin K also activates nuclear receptor SXR/PXR as a ligand. We generated conditional GGCX and PXR knockout mice to study the physiological and pathopysiological roles of vitamin K. PXR knockout mice displayed osteopenia. Liver-specific Ggcx knockout mice display short life span due to hemorrhage. Using these animal models we can study differential roles and mechanisms of vitamin K action.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Liver-specific γ-glutamyl carboxylase-1 deficient mice display bleeding diathesis and short life span.2014
Author(s)
Azuma K, Tsukui T, Ikeda K, Shiba S, Nakagawa K, Okano T, Urano T, Horie-Inoue K, Ouchi Y, Ikawa M, Inoue S
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Journal Title
PLoS ONE
Volume: 9
Issue: 2
Pages: e88643-e88643
DOI
Related Report
Peer Reviewed
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[Journal Article] GPR98/Gpr98 Gene Is Involved in the Regulation of Human and Mouse Bone Mineral Density2012
Author(s)
Urano, T., Shiraki, M, . Yagi, H., Ito, M., Sasaki, N., Sato, M., Ouchi, Y. and Inoue, S.
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Journal Title
J. Clin. Endocrinol. Metab
Volume: 97(4)
Issue: 4
Pages: E565-E574
DOI
Related Report
Peer Reviewed
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