| Project/Area Number |
24659128
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | NF-kappaB / 細胞分化 / 胸腺 / シグナル伝達 / エピゲノム / 遺伝子発現 / NF-kB |
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| Research Abstract |
RelB is a member of NF-kB family, which is activated by various extra-cellular signaling, and regulates differentiation of immune stroma cells in several lymphoid tissues including thymus. This project provides information regarding to roles of RelB in differentiation of medullary thymic epithelial cells that are essential for preventing the onset of autoimmune diseases. Moreover, dynamics of nuclear localization of RelB induced by stimulation has been newly identified in this study. These findings would contribute to uncovering molecular mechanisms underlying stimulus-dependent activations of RelB and also would provide new insights in the molecular mechanism regulating differentiation of medullary thymic epithelial cells.
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