Exploration of novel molecular targets for anti-cancer drug in long non-coding RNAs
| Project/Area Number |
24659130
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ノンコーディングRNA / 癌抑制遺伝子 / INK4 locus / エピジェネティクス / 癌 |
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| Research Abstract |
lncRNA ANRIL negatively regulates tumore suppressor p16Ink4 via recruitment of PRC2. We found that RNA immunoprecipitation method is applicable for a screening system to evaluate the binding between ANRIL and SUZ12, a component of PRC2. Moreover, we developed quantitation methods to measure fifteen known lncRNAs including ANRIL to evaluate their association with cancer development. Although, we evaluate them in hepatocellular carcinoma cell lines with or without HBx-expression using this system, there are no lncRNA oscillating by HBx-expression. Further evaluation will be required.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers2014
Author(s)
Harada, M., Kotake, Y., Ohhata, T., Kitagawa, K., Niida, H., Matsuura, S., Funai, K., Sugimura, H., Suda, T. and Kitagawa, M.
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Journal Title
Genes Cells
Volume: 18
Issue: 6
Pages: 999-1006
DOI
Related Report
Peer Reviewed
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[Journal Article] Interaction between RB protein and NuMA is required for proper alignment of spindle microtubules2014
Author(s)
Uchida, C., Hattori, T., Takahashi, H., Yamamoto, N., Kitagawa, M. and Taya, Y.
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Journal Title
Genes Cells
Volume: 19
Issue: 2
Pages: 89-96
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts.2014
Author(s)
Miyazaki S, Kikuchi H, Iino I, Uehara T, Setoguchi T, Fujita T, Hiramatsu Y, Ohta M, Kamiya K, Kitagawa K, Kitagawa M, Baba S, Konno H
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Journal Title
Int J Cancer
Volume: 135
Issue: 2
Pages: 295-307
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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