Research Project
Grant-in-Aid for Challenging Exploratory Research
NF-kappaB is a family of a transcription factor that involves in various biologcal phenomena including inflammation, immune responses, and cell survival. Abnormal activation NF-kappaB is also known to be related to the pathogenesis of various diseases. Thus, regulation of NF-kappaB is a suitable target of drugs for those diseases. Since we have identified LUBAC-mediated linear polyubiquitination is involved in NF-kappaB activation, we tried to develop the agents that up-regulate or inhibit LUBAC's ligase activity. We then identified a small chemical that inhibits LUBAC-mediated linear polyubiquitination and NF-kappaB actvation. Also, we found that interferon-gamma increases the amount of LUBAC and enhances NF-kappaB actvation.
All 2014 2013 2012 Other
All Journal Article (9 results) (of which Peer Reviewed: 8 results, Open Access: 3 results, Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Invited: 5 results) Remarks (2 results)
J. Immunol.
Volume: 192 Pages: 3793-3804
Genes Cells.
Volume: 19 Issue: 3 Pages: 254-272
10.1111/gtc.12128
Mol. Cell. Biol.
Volume: 34 Issue: 7 Pages: 1322-1335
10.1128/mcb.01538-13
Cancer Discov.
Volume: 4 Issue: 4 Pages: 480-493
10.1158/2159-8290.cd-13-0915
EMBO J.
Volume: 32 Issue: 18 Pages: 2463-2476
10.1038/emboj.2013.184
J. Cell Biol.
Volume: 203 Issue: 1 Pages: 115-128
10.1083/jcb.201304188
Trends Cell Biol.
Volume: 22 Issue: 7 Pages: 355-364
10.1016/j.tcb.2012.04.001
Endocr. J.
Volume: 59 Pages: 641-652
Volume: 31 Issue: 19 Pages: 3856-3870
10.1038/emboj.2012.241
http://www.mcp.med.kyoto-u.ac.jp/