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Basic Research on Tissue Regeneration for Radiation Emergency Medicine

Research Project

Project/Area Number 24659140
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionKawasaki Medical School

Principal Investigator

INUBUSHI Masayuki  川崎医科大学, 医学部, 准教授 (70399830)

Co-Investigator(Kenkyū-buntansha) MICHIKAWA Yuichi  独立行政法人放射線医学総合研究所, 緊急被ばく医療研究センター, 主任研究員 (20360688)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords再生医学 / 分子イメージング
Research Abstract

We extracted stem cells from various organs of a transgenic mouse systemically and constitutively expressing the sodium/ iodide symporter (NIS) gene (NIS-Tg mouse), which was originally developed by this principle investigator. We found adipose-derived stem cells showed higher 99mTc uptake than bone marrow stem cells in NIS-Tg mice. We transplanted 100000 adipose-derived stem cells of NIS-Tg mice into mice after irradiation to one side of the body, and 48 hours later we succeeded in detecting apparent signals at the transplanted region with 99mTc SPECT imaging. The transplanted cells could be tracked for more than 1 month in the same living mice, and we discussed the significance from the viewpoint of regenerative medicine.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (37 results)

All 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (27 results) (of which Invited: 3 results) Book (2 results) Remarks (1 results)

  • [Journal Article] FDG uptake heterogeneity evaluated by fractal analysis improves the differential diagnosis of pulmonary nodules.2014

    • Author(s)
      Miwa K, Inubushi M, Wagatsuma K, Nagao M, Murata T, Koyama M, Koizumi M, Sasaki M
    • Journal Title

      Eur J Radiol

      Volume: 83 Issue: 4 Pages: 715-719

    • DOI

      10.1016/j.ejrad.2013.12.020

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncology PET imaging2014

    • Author(s)
      犬伏正幸
    • Journal Title

      医学物理

      Volume: 印刷中

    • NAID

      130005002761

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development.2013

    • Author(s)
      Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y.
    • Journal Title

      Nucl Med Biol

      Volume: 40 Issue: 5 Pages: 643-650

    • DOI

      10.1016/j.nucmedbio.2013.03.006

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictive value of 3'-deoxy-3'-[(18)F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma.2013

    • Author(s)
      Inubushi M
    • Journal Title

      Ann Nucl Med

      Volume: 27 Issue: 1 Pages: 1-10

    • DOI

      10.1007/s12149-012-0652-x

    • NAID

      10031168062

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel human monoclonal antibody against epidermal growth factor receptor as an imaging probe for hepatocellular carcinoma.2012

    • Author(s)
      Sogawa C
    • Journal Title

      Nucl Med Commun

      Volume: 33 Issue: 1 Pages: 719-725

    • DOI

      10.1186/2191-219x-2-46

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel human monoclonal antibody against epidermal growth factor receptor as an imaging probe for hepatocellular carcinoma2012

    • Author(s)
      Sogawa C
    • Journal Title

      Nucl Med Commun

      Volume: (in press) Issue: 7 Pages: 719-725

    • DOI

      10.1097/mnm.0b013e3283531d68

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model2012

    • Author(s)
      Jin YN, Inubushi M, Masamoto K, Odaka K, Aoki I, Tsuji AB, Sagara M, Koizumi M, Saga T
    • Journal Title

      Gene Ther

      Volume: 19(8) Issue: 8 Pages: 836-843

    • DOI

      10.1038/gt.2011.128

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス間葉系幹細胞の皮下移植による放射線誘発白毛化の抑制2014

    • Author(s)
      道川祐市、福崎智子、後藤希、徐華、犬伏正幸、松崎有美、田嶋克史
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      国立京都国際会館,京都
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス間葉系幹細胞の皮下移植による放射線誘発白毛化の抑制.2014

    • Author(s)
      道川祐市、福崎智子、後藤希、徐華、犬伏正幸、松崎有美、田嶋克史.
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      国立京都国際会館,京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comparison of Intratumoral 18FDG and 18FAZA Distribution in Non-small Cell Lung Cancer Using Deformable Image Registration2013

    • Author(s)
      Sasaki M, Koizumi M, Murata T, Wagatsuma K, Saga T, Inubushi M, Tachibana H, Miwa K
    • Organizer
      The 99th Scientific Assembly and Annual Meeting of the Radiological Society of North America
    • Place of Presentation
      McCormick Place, Chicago, IL
    • Related Report
      2013 Final Research Report
  • [Presentation] FDG Uptake Heterogeneity Evaluated by Fractal Analysis Improves the Differential Diagnosis of Pulmonary Nodules2013

    • Author(s)
      Sasaki M, Koizumi M, Umeda T, Okawa A, Umeda T, Wagatsuma K, Inubushi M, Miwa K
    • Organizer
      The 99th Scientific Assembly and Annual Meeting of the Radiological Society of North America
    • Place of Presentation
      McCormick Place, Chicago, IL
    • Related Report
      2013 Final Research Report
  • [Presentation] Noninvasive spatial and temporal tracking of multilayered cell sheet on infarcted heart using reporter gene imaging2013

    • Author(s)
      Otani K, Zeniya T, Kawashima H, Fukuda H, Hashikawa Y, Moriguchi T, Inubushi M, Iida H, Yamahara K
    • Organizer
      American Heart Association Scientific Sessions 2013
    • Place of Presentation
      Dallas Convention Center, Dallas, TX
    • Related Report
      2013 Final Research Report
  • [Presentation] The imaging of tumor hypoxia with 18F-FMISO and 18F-FAZA in comparison to the imaging of hypoxic response with radioiodine using sodium/iodine symporter (NIS) reporter gene in human xenograft tumors2013

    • Author(s)
      Takeuchi Y, Inubushi M, Xu H, Hata H, Kitagawa Y, Saga T
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging 2013 Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre, Vancouver, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of intratumoral distribution of 18FDG and 18FAZA using deformable image registration procedure in non-small cell lung cancer patients2013

    • Author(s)
      Miwa K, Tachibana H, Inubushi M, Wagatsuma K, Murata T, Takiguchi T, Koizumi M, Saga T, Sasaki M
    • Organizer
      The 69th Annual Scientific Congress of the Japanese Society of Radiological Technology
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Related Report
      2013 Final Research Report
  • [Presentation] 腫瘍PETイメージング.2013

    • Author(s)
      犬伏正幸.
    • Organizer
      第106回日本医学物理学会学術大会
    • Place of Presentation
      大阪大学コンベンションセンター,吹田
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Comparison of intratumoral distribution of 18F-FMISO and 64Cu-ATSM with region genetically responding to hypoxia by quantitative cluster analyses.2013

    • Author(s)
      Takeuchi Y
    • Organizer
      2013 Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] 腫瘍の治療抵抗性を評価する低酸素応答イメージング.2013

    • Author(s)
      竹内康人
    • Organizer
      第5回口腔先端応用医科学研究会学術会議 (口腔先端応用医科学若手研究賞受賞)
    • Place of Presentation
      日本大学会館大講堂 (東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 心筋梗塞モデルラットに移植したhNIS発現細胞シートのSPECTイメージング2013

    • Author(s)
      河嶋秀和
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Comparison of intratumoral distribution of 18FDG and 18FAZA using deformable image registration procedure in non-small cell lung cancer patients.2013

    • Author(s)
      Miwa K
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Predictive value of 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma2012

    • Author(s)
      Inubushi M, Saga T, Koizumi M, Takagi R, Hasegawa A, Koto M, Wakatuki M, Morikawa T, Yoshikawa K, Tanimoto K, Fukumura T, Yamada S, Kamada T
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine 2012
    • Place of Presentation
      Milano Congressi (MiCo), Milan, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Tracking of transplanted stem cells in myocardial infarction model rat : validation of simultaneous dual-isotope SPECT imaging with Tc-99m and Tl-2012012

    • Author(s)
      Zeniya T, Kawashima H, Otani K, Fukuda H, Hashikawa Y, Koshino K, Hori Y, Moriguchi T, Enmi J, Iguchi S, Yamamoto A, Miyake Y, Inubushi M, Iida H
    • Organizer
      2012 World Molecular Imaging Congress
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical differentiation between malignant and benign pulmonary nodules using heterogeneity of 18F-FDG uptake distribution2012

    • Author(s)
      Miwa K, Wagatsuma K, Sasaki M, Nagao M, Koyama M, Inubushi M, Koizumi M
    • Organizer
      2012 Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Miami Beach, FL
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular genetic imaging of hypoxia response using sodium/iodide symporter (NIS) reporter gene2012

    • Author(s)
      Takeuchi Y, Inubushi M, Xu H, Mio K, Hata H, Kitagawa Y, Saga T
    • Organizer
      2012 Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Miami Beach, FL
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス自然発生肝転移モデルのSPECTイメージング2012

    • Author(s)
      犬伏正幸、竹内康人、村井知佳、秦浩信、北川善政、佐賀恒夫
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      さっぽろ芸術文化の館/ロイトン札幌(札幌)
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular genetic imaging of hypoxia response using sodium/iodide symporter (NIS) reporter gene.2012

    • Author(s)
      Takeuchi Y
    • Organizer
      2012 Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Miami Beach, FL, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical differentiation between malignant and benign pulmonary nodules using heterogeneity of 18F-FDG uptake distribution.2012

    • Author(s)
      Miwa K
    • Organizer
      2012 Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Miami Beach, FL, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Tracking of transplanted stem cells in myocardial infarction model rat: validation of simultaneous dual-isotope SPECT imaging with Tc-99m and Tl-201.2012

    • Author(s)
      Zeniya T
    • Organizer
      2012 World Molecular Imaging Congress
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2012 Research-status Report
  • [Presentation] Predictive value of 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma.2012

    • Author(s)
      Inubushi M
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine 2012
    • Place of Presentation
      Milan, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺結節病変の18FDG集積分布の不均一性による良悪性鑑別2012

    • Author(s)
      三輪建太
    • Organizer
      第68回日本放射線技術学会総会学術大会 (学術展示賞金賞受賞)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 遺伝子発現イメージング2012

    • Author(s)
      犬伏正幸
    • Organizer
      第25回海の中道RIカンファランス (招待講演)
    • Place of Presentation
      山の上ホテル(福岡県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] マウス自然発生肝転移モデルのSPECTイメージング2012

    • Author(s)
      犬伏正幸
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] Na+/I-共輸送タンパクを用いた低酸素応答の分子遺伝子イメージング.2012

    • Author(s)
      竹内康人
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] 低酸素に対する遺伝子応答にもとづく腫瘍の治療抵抗性の新しい評価方法.2012

    • Author(s)
      竹内康人
    • Organizer
      第57回日本口腔外科学会総会・学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 腫瘍PETイメージング2012

    • Author(s)
      犬伏正幸
    • Organizer
      日本応用物理学会放射線分科会 (招待講演)
    • Place of Presentation
      大阪大学医学部保健学科 (大阪府)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 核医学技術総論改訂版2014

    • Author(s)
      犬伏正幸, 他
    • Publisher
      山代印刷(京都)(印刷中)
    • Related Report
      2013 Final Research Report
  • [Book] 核医学技術総論(改訂版)2014

    • Author(s)
      犬伏正幸,孫田恵一.
    • Publisher
      山代印刷
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://kwweb-res.kawasaki-m.ac.jp/kwmhp/KgApp?kyoinId=Kgyysggk

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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