Basic Research on Tissue Regeneration for Radiation Emergency Medicine
| Project/Area Number |
24659140
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MICHIKAWA Yuichi 独立行政法人放射線医学総合研究所, 緊急被ばく医療研究センター, 主任研究員 (20360688)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 再生医学 / 分子イメージング |
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| Research Abstract |
We extracted stem cells from various organs of a transgenic mouse systemically and constitutively expressing the sodium/ iodide symporter (NIS) gene (NIS-Tg mouse), which was originally developed by this principle investigator. We found adipose-derived stem cells showed higher 99mTc uptake than bone marrow stem cells in NIS-Tg mice. We transplanted 100000 adipose-derived stem cells of NIS-Tg mice into mice after irradiation to one side of the body, and 48 hours later we succeeded in detecting apparent signals at the transplanted region with 99mTc SPECT imaging. The transplanted cells could be tracked for more than 1 month in the same living mice, and we discussed the significance from the viewpoint of regenerative medicine.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Novel human monoclonal antibody against epidermal growth factor receptor as an imaging probe for hepatocellular carcinoma2012
Author(s)
Sogawa C, Tsuji AB, Yoshida C, Inubushi M, Furukawa T, Koizumi M, Akahori Y, Ukai Y, Kurosawa G, Kurosawa Y, Saga T
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Journal Title
Nucl Med Commun
Volume: 33(7)
Pages: 719-725
DOI
Related Report
Peer Reviewed
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[Presentation] Noninvasive spatial and temporal tracking of multilayered cell sheet on infarcted heart using reporter gene imaging2013
Author(s)
Otani K, Zeniya T, Kawashima H, Fukuda H, Hashikawa Y, Moriguchi T, Inubushi M, Iida H, Yamahara K
Organizer
American Heart Association Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, TX
Related Report
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[Presentation] Predictive value of 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma2012
Author(s)
Inubushi M, Saga T, Koizumi M, Takagi R, Hasegawa A, Koto M, Wakatuki M, Morikawa T, Yoshikawa K, Tanimoto K, Fukumura T, Yamada S, Kamada T
Organizer
Annual Congress of the European Association of Nuclear Medicine 2012
Place of Presentation
Milano Congressi (MiCo), Milan, Italy
Related Report
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[Presentation] Tracking of transplanted stem cells in myocardial infarction model rat : validation of simultaneous dual-isotope SPECT imaging with Tc-99m and Tl-2012012
Author(s)
Zeniya T, Kawashima H, Otani K, Fukuda H, Hashikawa Y, Koshino K, Hori Y, Moriguchi T, Enmi J, Iguchi S, Yamamoto A, Miyake Y, Inubushi M, Iida H
Organizer
2012 World Molecular Imaging Congress
Place of Presentation
Dublin, Ireland
Related Report
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