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Search for biomarkers of successful aging through glycomics and glycoproteomics of semisuper centenarians

Research Project

Project/Area Number 24659141
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

ENDO Tamao  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 副所長 (30168827)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsプロテオミクス / 超百寿者 / 健康長寿マーカー / 糖鎖解析 / レクチンマイクロアレイ / 糖タンパク質 / LC-MS / グライコプロテオミクス / LC-MS/MS
Research Abstract

The purpose of this study is to clarify the candidates of the biomarker of successful aging through glycomics and glycoproteomics of semisuper centenarians considered as a model of human longevity. I performed sugar chains analyses, lectin microarray analyses, and glycopeptides analyses, and compared the glycosylation of plasma proteins between semisuper centenarians and controls. As a result, multi-branched complex sugar chains and high sialylated sugar chains were increased in the plasma proteins of semisuper centenarians. Sialylated glycopeptides of inflammatory mediating proteins were decreased with aging, while not in semisuper centenarians. It was suggested that the glycosylation plays an important role in successful aging of semisuper centenarians.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] 健康長寿への挑戦ー長寿者プロテオミクスが明らかにするものとはー2013

    • Author(s)
      三浦ゆり、遠藤玉夫
    • Journal Title

      基礎老化研究

      Volume: 37 Pages: 23-27

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 健康長寿への挑戦 -長寿者プロテオミクスが明らかにするものとは-2013

    • Author(s)
      遠藤玉夫、三浦ゆり
    • Journal Title

      基礎老化研究

      Volume: 37 Pages: 23-27

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人超百寿者血漿タンパク質のグライコプロテオミクス解析2014

    • Author(s)
      三浦ゆり、太田悠葵、高倉大輔、橋井則貴、新井康通、津元裕樹、川崎ナナ、広瀬信義、遠藤玉夫
    • Organizer
      第37回日本基礎老化学会大会
    • Place of Presentation
      大府
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Proteomics of Plasma Proteins in Japanese Semisuper Centenarians2014

    • Author(s)
      Miura, Y., Arai, Y., Toda, T., Hirose, N., Endo, T.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International (SFRR 2014)
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Glycoproteomics study of plasma glycoproteins in Japanese semisuper centenarians2013

    • Author(s)
      Miura, Y., Itakura, Y., Arai, Y., Iwamoto, M., Toyoda, M., Kinoshita, H., Unuma, Y., Toda, T., Hirose, N., Endo, T.
    • Organizer
      12^<th> Human Proteome Organization (HUPO) World Congress
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本人超百寿者血漿のグライコプロテオミクス解析2013

    • Author(s)
      三浦ゆり、板倉陽子、豊田雅士、木下英樹、広瀬信義、遠藤玉夫
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Glycoproteomics study of plasma glycoproteins in Japanese semisuper centenarians2013

    • Author(s)
      Yuri Miura, Yoko Itakura, Yasumichi Arai, Machiko Iwamoto, Masashi Toyoda, Hideki Kinoshita, Yutaka Unuma, Tosifusa Toda, Nobuyoshi Hirose, Tamao Endo
    • Organizer
      12th Human Proteome Organization (HUPO) World Congress
    • Place of Presentation
      Pacifico Yokohama (Kanagawa, Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] レクチンマイクロアレイを用いた日本人超百寿者血漿のグライコプロテオミクス2012

    • Author(s)
      三浦ゆり、板倉陽子、新井康通、豊田雅士、木下英樹、丸尾祐二、鵜沼豊、戸田年総、広瀬信義、遠藤玉夫
    • Organizer
      第35回日本基礎老化学会大会
    • Place of Presentation
      習志野
    • Related Report
      2013 Final Research Report
  • [Presentation] レクチンマイクロアレイを用いた日本人超百寿者血漿のグライコプロテオミクス2012

    • Author(s)
      三浦ゆり、板倉陽子、新井康通、豊田雅士、木下英樹、丸尾祐二、鵜沼 豊、戸田年総、広瀬信義、遠藤玉夫
    • Organizer
      第35回日本基礎老化学会大会
    • Place of Presentation
      東邦大学習志野キャンパス(千葉県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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