| Project/Area Number |
24659141
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
ENDO Tamao 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 副所長 (30168827)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | プロテオミクス / 超百寿者 / 健康長寿マーカー / 糖鎖解析 / レクチンマイクロアレイ / 糖タンパク質 / LC-MS / グライコプロテオミクス / LC-MS/MS |
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| Research Abstract |
The purpose of this study is to clarify the candidates of the biomarker of successful aging through glycomics and glycoproteomics of semisuper centenarians considered as a model of human longevity. I performed sugar chains analyses, lectin microarray analyses, and glycopeptides analyses, and compared the glycosylation of plasma proteins between semisuper centenarians and controls. As a result, multi-branched complex sugar chains and high sialylated sugar chains were increased in the plasma proteins of semisuper centenarians. Sialylated glycopeptides of inflammatory mediating proteins were decreased with aging, while not in semisuper centenarians. It was suggested that the glycosylation plays an important role in successful aging of semisuper centenarians.
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