Development of new therapies for tumor and autoimmunity using CD8aaT cells
Project/Area Number |
24659148
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | Kyoto University |
Principal Investigator |
SUGAI Manabu 京都大学, 医学(系)研究科(研究院), 講師 (90303891)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 自己免疫疾患 / 制御性T細胞 / 腫瘍免疫 |
Research Abstract |
Cell fate determination of helper T cells (CD4 T cells) or cytotoxic T cells (CD8 T cells) is mutually exclusive process depending on antigen recognition, which occurs in the thymus. We found that retinoic acid and transforming growth factor-b1 promoted the differentiation of CD8 aaT cells from CD4 T cells in peripheral lymphoid tissues. And we examined the expression patterns of various genes in differentiated CD8aa T cells and compared with those in iTreg cells. Furthermore, we found various compounds, which regulate differentiation of CD8aa T cells from CD4 cells.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells2014
Author(s)
Naito-Matsui, Y., Takada, S., Kano, Y., Iyoda, T., Sugai, M., Shimizu, A., Inaba, K., Nitschke, L., Tsubata, T., Oka, S., Kozutsumi, Y. and Takematsu, H.
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Journal Title
J . Biol. Chem.
Volume: 289
Pages: 1564-1579
Related Report
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[Journal Article] Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.2014
Author(s)
Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H.
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Journal Title
J. Biol. Chem.
Volume: 289
Issue: 3
Pages: 1564-1579
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phenotypes of CCAAT/enhancer-binding protein beta deficiency : hyperdontia2013
Author(s)
Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Shimizu, A. and Bessho, K.
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Journal Title
Related Report
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[Journal Article] Evasion from accelerated blood clearance of nanocarrier named as"Lactosome"2013
Author(s)
Hara, E., Makino, A., Kurihara, K., Sugai, M.,Shimizu, A., Hara, I., Ozeki, E., Kimura, S.
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Journal Title
Biochim. Biophys. Acta
Volume: 1830
Related Report
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[Journal Article] Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome.2013
Author(s)
Hara, E., Makino, A., Kurihara, K., Sugai, M., Shimizu, A., Hara, I., Ozeki, E. and Kimura, S.
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Journal Title
Biochem. Biophys. Acta-General Sub.
Volume: 1830
Issue: 8
Pages: 4046-4052
DOI
Related Report
Peer Reviewed
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[Journal Article] Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process.2013
Author(s)
Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Akira, S., Shimizu, A. and Bessho, K.
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Journal Title
Oral Diseases
Volume: 19
Issue: 2
Pages: 144-150
DOI
Related Report
Peer Reviewed
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[Journal Article] In situ differentiation of CD8ααT cells from CD4 T cells in peripheral lymphoid tissues2012
Author(s)
Nambu, Y., Hayashi, T., Jang, KJ., Aoki, K., Mano, H., Nakano, K., Osato, M., Takahashi, K., Itoh, K., Teramukai, S., Komori, T.,Fujita, J., Ito, Y., Shimizu, A. & Sugai, M.
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Journal Title
Scientific Reports
Volume: 2
Pages: 645-623
Related Report
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[Journal Article] Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis2012
Author(s)
Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M., Nakamura, T., Tokota, Y., Shimizu, A., Slavkin, H. and Bessho, K.
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Journal Title
Bone
Volume: 50
Pages: 69-78
Related Report
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[Journal Article] In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues2012
Author(s)
Nambu Y., Hayashi T., Jang KJ, Aoki K., Mano H., Nakano K., Osato M., Takabashi K., Itoh K., Teramukai S., Komon T., Fujita J., Ito Y., Shimizu
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Journal Title
Scientific Reports
Volume: 2
Issue: 1
Pages: 930-930
DOI
Related Report
Peer Reviewed
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[Presentation] In situ differentiation of CD8aa T cells from CD4 Tcells in peripheral lymphoid tissues2012
Author(s)
Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M
Organizer
日本分子生物学会年会
Place of Presentation
福岡
Related Report
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