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Development of new therapies for tumor and autoimmunity using CD8aaT cells

Research Project

Project/Area Number 24659148
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKyoto University

Principal Investigator

SUGAI Manabu  京都大学, 医学(系)研究科(研究院), 講師 (90303891)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自己免疫疾患 / 制御性T細胞 / 腫瘍免疫
Research Abstract

Cell fate determination of helper T cells (CD4 T cells) or cytotoxic T cells (CD8 T cells) is mutually exclusive process depending on antigen recognition, which occurs in the thymus. We found that retinoic acid and transforming growth factor-b1 promoted the differentiation of CD8 aaT cells from CD4 T cells in peripheral lymphoid tissues. And we examined the expression patterns of various genes in differentiated CD8aa T cells and compared with those in iTreg cells. Furthermore, we found various compounds, which regulate differentiation of CD8aa T cells from CD4 cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012 Other

All Journal Article (13 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (5 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells2014

    • Author(s)
      Naito-Matsui, Y., Takada, S., Kano, Y., Iyoda, T., Sugai, M., Shimizu, A., Inaba, K., Nitschke, L., Tsubata, T., Oka, S., Kozutsumi, Y. and Takematsu, H.
    • Journal Title

      J . Biol. Chem.

      Volume: 289 Pages: 1564-1579

    • Related Report
      2013 Final Research Report
  • [Journal Article] Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.2014

    • Author(s)
      Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 3 Pages: 1564-1579

    • DOI

      10.1074/jbc.m113.523753

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phenotypes of CCAAT/enhancer-binding protein beta deficiency : hyperdontia2013

    • Author(s)
      Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Shimizu, A. and Bessho, K.
    • Journal Title

      Oral Diseases

      Volume: 19

    • Related Report
      2013 Final Research Report
  • [Journal Article] The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues2013

    • Author(s)
      Kurooka, H., Sugai, M., Mori, K. and Yokota, Y.
    • Journal Title

      Biochem.Biophys. Res. Commun.

      Volume: 433

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evasion from accelerated blood clearance of nanocarrier named as"Lactosome"2013

    • Author(s)
      Hara, E., Makino, A., Kurihara, K., Sugai, M.,Shimizu, A., Hara, I., Ozeki, E., Kimura, S.
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1830

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome.2013

    • Author(s)
      Hara, E., Makino, A., Kurihara, K., Sugai, M., Shimizu, A., Hara, I., Ozeki, E. and Kimura, S.
    • Journal Title

      Biochem. Biophys. Acta-General Sub.

      Volume: 1830 Issue: 8 Pages: 4046-4052

    • DOI

      10.1016/j.bbagen.2013.03.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues2013

    • Author(s)
      Kurooka, H., Sugai, M., Mori, K. and Yokota, Y.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 433 Issue: 4 Pages: 579-585

    • DOI

      10.1016/j.bbrc.2013.03.027

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process.2013

    • Author(s)
      Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Akira, S., Shimizu, A. and Bessho, K.
    • Journal Title

      Oral Diseases

      Volume: 19 Issue: 2 Pages: 144-150

    • DOI

      10.1111/j.1601-0825.2012.01963.x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ differentiation of CD8ααT cells from CD4 T cells in peripheral lymphoid tissues2012

    • Author(s)
      Nambu, Y., Hayashi, T., Jang, KJ., Aoki, K., Mano, H., Nakano, K., Osato, M., Takahashi, K., Itoh, K., Teramukai, S., Komori, T.,Fujita, J., Ito, Y., Shimizu, A. & Sugai, M.
    • Journal Title

      Scientific Reports

      Volume: 2 Pages: 645-623

    • Related Report
      2013 Final Research Report
  • [Journal Article] Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis2012

    • Author(s)
      Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M., Nakamura, T., Tokota, Y., Shimizu, A., Slavkin, H. and Bessho, K.
    • Journal Title

      Bone

      Volume: 50 Pages: 69-78

    • Related Report
      2013 Final Research Report
  • [Journal Article] 制御性T細胞と大腸炎関連派発癌GI2012

    • Author(s)
      菅井学、南部由希子、清水章
    • Journal Title

      Research

      Volume: 20(6) Pages: 466-471

    • Related Report
      2013 Final Research Report
  • [Journal Article] In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues2012

    • Author(s)
      Nambu Y., Hayashi T., Jang KJ, Aoki K., Mano H., Nakano K., Osato M., Takabashi K., Itoh K., Teramukai S., Komon T., Fujita J., Ito Y., Shimizu
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 930-930

    • DOI

      10.1038/srep00642

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis2012

    • Author(s)
      Sakata-Goto T
    • Journal Title

      Bone

      Volume: 50 Issue: 1 Pages: 69-78

    • DOI

      10.1016/j.bone.2011.09.049

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Essential role of SIP1 and CD19 in B cell differentiation2013

    • Author(s)
      Hayashi T, Nambu Y, Jang KJ, Mano H, Higashi Y, Kristin V, Danny H, Shimizu A, Sugai M
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Essential role of SIP1 and CD19 in B cell differentiation2012

    • Author(s)
      Hayashi T, Nambu Y, Jang KJ, Mano H, Higashi Y, Kristin V, Danny H, Shimizu A, Sugai M
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] In situ differentiation of CD8aa T cells from CD4 Tcells in peripheral lymphoid tissues2012

    • Author(s)
      Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues2012

    • Author(s)
      南部 由希子、林 達成、Kyoung-Jin Jang、青木 耕史、眞野浩人、中野圭子、大里 元美、髙橋 克、 伊藤 克彦、手良向 聡、小守 壽文、藤田 潤、伊藤 嘉明、清水 章 、菅井 学
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Essential role of SIP1 and CD19 in B cell differentiation

    • Author(s)
      HAYASHI T., NAMBU Y., MANO H., HIGASHI Y., Kristin V., Danny H., SHIMIZU A. and SUGAI M.
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] T細胞の分化誘導方法、T細胞の製造方法、T細胞、医薬組成物、及び、スクリーニング方法2013

    • Inventor(s)
      菅井学、清水章、南部由希子
    • Industrial Property Rights Holder
      京都大学
    • Filing Date
      2013-03-12
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] T細胞の分化誘導方法、T細胞の製造方法、T細胞、医薬組成物、及び、スクリーニング方法2012

    • Inventor(s)
      菅井学、清水章、南部由希子
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-04-26
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] T細胞の分化誘導方法、T細胞の製造方法、T細胞、医薬組成物、及び、スクリーニング方法2012

    • Inventor(s)
      菅井学、清水章、南部由希子
    • Industrial Property Rights Holder
      菅井学、清水章、南部由希子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-101390
    • Filing Date
      2012-04-26
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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