Molecular mechanism of cancer cell pluripotency responding to stress

• Project/Area Number: 24659149
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Osaka University
• Principal Investigator: KANEDA Yasufumi 大阪大学, 医学(系)研究科(研究院), 教授 (10177537)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 癌幹細胞 / 抗がん剤耐性 / 前立腺がん / 多能性維持因子 / ストレス応答 / 抗癌剤耐性 / 前立腺癌

Research Abstract

Despite an increasing prevalence of patients with docetaxel refractory prostate cancer, little is known about its tumour biology. In this study, we demonstrated that the tumourigenic potential was increased in the docetaxel-resistant residual prostate cancer cells compared with the parental prostate cancer cells. An enhanced tumourigenic potential was controlled by the CXCR4, ERK1/2 and c-Myc signalling loop activation. Furthermore, the constitutive CXCR4, ERK1/2 and c-Myc signalling activation was demonstrated in clinical cancerous tissue samples from human patients with docetaxel-resistant prostate cancer. These signalling pathways may become treatment targets for inhibiting aggressive residual tumour cells after chemotherapy.

Research Products

• [Journal Article] Residual Prostate Cancer Cells after Docetaxel Therapy Increase the Tumorigenic Potential via Constitutive Signaling of CXCR4, ERK1/2 and c-Myc (2013)
  • Author(s): Hatano K, Yamaguchi S, Nimura K, Murakami K, Nagahara A, Fujita K, Uemura M, Nakai Y, Tsuchiya M, Nakayama M, Nonomura N, *Kaneda Y.
  • Journal Title: Mol Cancer Research Volume: 11 Issue: 9 Pages: 1088-1100
  • DOI: 10.1158/1541-7786.mcr-13-0029-t
  • Peer Reviewed
• [Presentation] What will be needed for gene therapy in Japan? (2013)
  • Author(s): 金田安史
  • Organizer: 第19回日図7本遺伝子治療学会理事長講演
  • Place of Presentation: 岡山
  • Year and Date: 2013-07-04
• [Presentation] Future direction of gene therapy (2012)
  • Author(s): 金田安史
  • Organizer: 第18回日本遺伝子治療学会理事長講演
  • Place of Presentation: 熊本
  • Year and Date: 2012-06-28
• [Presentation] Future directions of gene therapy (2012)
  • Author(s): 金田安史
  • Organizer: 第18回日本遺伝子治療学会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] What will be needed for genetherapy in Japan?
  • Author(s): Yasufumi Kaneda
  • Organizer: 第19回日本遺伝子治療学会
  • Place of Presentation: 岡山
  • Invited
• [Remarks] 大阪大学大学院医学系研究科遺伝子治療学ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/gts/
• [Remarks] 大阪大学大学院学系研究科遺伝子治療学
  • URL: http://www.med.osaka-u.ac.jp/pub/gts/