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IgG4 reaction in cholangiocarcinoma and pancreatic carcinoma reflects an evasion from host immunosurveilance by carcinoma

Research Project

Project/Area Number 24659160
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionKanazawa University

Principal Investigator

NAKANUMA YASUNI  金沢大学, 医学系, 教授 (10115256)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords付属腺 / 胆道腫瘍 / 膵腫瘍 / 膵外分泌腺
Research Abstract

The relation between cholangiocarcinoma and its precursor lesion (BilIN) and IgG4-related tissue reaction with respect to carcinogenesis was examined. About 30% of cholangiocarcinoma and BilIN showed infiltration of considerable number of IgG4+ plasma cells. There is correlation between expression of Fox3 and IgG4 tissue reaction. Clinicopathological study showed that the cholangiocarcinoma patients with IgG4 tissue reaction showed poor biological behaviors and poor post-operative survival. Cell culture studies showed that cultured cholangiocarcinoma cells express Fox3 mRNA and IL10 mRNA, and cancer cells present immunoregulatory roles by expressing these molecules. It seems plausible that cancer cells themselves are involved in IgG4 tissue reaction. In conclusion, some cholangiocarcinoma showed rich IgG4+ plasma cells and IgG4 tissue reaction reflect an evasion from immunosurveillance of host and cancer cells themsevels are involved in IgG4 tissue reaction by playing roles of Tregs.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (37 results)

All 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (16 results) (of which Invited: 1 results) Book (5 results)

  • [Journal Article] PSC・IgG4-SC. PSCの病理診断2014

    • Author(s)
      中沼安二、佐々木素子、佐藤保則、原田憲一
    • Journal Title

      肝胆膵

      Volume: 68(1) Pages: 9-17

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases2014

    • Author(s)
      Nakanuma Y, Harada K, Sasaki M, Sato Y
    • Journal Title

      Histol Histopathol

      Volume: 29(1) Pages: 1-10

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hilar cholangiocarcinoma is pathologically similar to pancreatic duct adenocarcinoma: suggestions of similar background and development.2014

    • Author(s)
      Nakanuma Y, Sato Y.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: Jan 21 Issue: 7 Pages: 70-70

    • DOI

      10.1002/jhbp.70

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases.2014

    • Author(s)
      Nakanuma Y, Harada K, Sasaki M, Sato Y.
    • Journal Title

      Histol Histopathol

      Volume: 29(1) Pages: 1-10

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PSC・IgG4-SC. PSCの病理診断.2014

    • Author(s)
      中沼 安二、 佐々木 素子、 佐藤 保則、 原田 憲一.
    • Journal Title

      肝胆膵

      Volume: 68(1) Pages: 9-17

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis2013

    • Author(s)
      Zen Y, Liberal R, Nakanuma Y, Heaton N, Portmann B
    • Journal Title

      J Hepatol

      Volume: 59(5) Pages: 1059-64

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集 : IgG4と肝胆膵.胆道癌とIgG4関連病態2013

    • Author(s)
      原田憲一、中沼安二
    • Journal Title

      肝胆膵

      Volume: 67(3) Pages: 415-24

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis.2013

    • Author(s)
      Zen Y, Liberal R, Nakanuma Y, Heaton N, Portmann B.
    • Journal Title

      J Hepatol

      Volume: 59(5) Pages: 1059-64

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgG4と肝胆膵. 胆道癌とIgG4関連病態.2013

    • Author(s)
      原田 憲一、 中沼 安二
    • Journal Title

      肝胆膵

      Volume: 67(3) Pages: 415-24

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A clinicopathologic study of immunoglobulin G4-related disease of the femoral and popliteal arteries in the spactrum of immunoglobulin G4-reralted periarteritis.2013

    • Author(s)
      Kasashima S, Kawashima A, Endo M, Nakanuma Y
    • Journal Title

      J Vasc Surg

      Volume: 57(3) Pages: 816-22

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] IgG4 cholangiopathy2012

    • Author(s)
      Zen Y, Nakanuma Y.
    • Journal Title

      International Journal of Hepatology

      Volume: - Pages: 1-10

    • DOI

      10.1155/2012/793569

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of IgG4-positive cells in extrahepatic cholangiocarcinoma: Molecular mechanism of IgG4 r5ection in cancer tissue2012

    • Author(s)
      Harada K, Shimoda S, Kimura Y, Sato Y, Ikeda H, Igarashi S, Ren XS, Sato H, Nakanuma Y.
    • Journal Title

      Hepatology

      Volume: 167(3) Pages: 532-42

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathologic significance of immunoglobulin G4-positive plasma cells in extrahepatic cholangiocarcinoma2012

    • Author(s)
      Kimura Y, Harada K, Nakanuma Y.
    • Journal Title

      Hum Pathol

      Volume: 43(12) Pages: 2149-56

    • NAID

      120005253291

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Consensus statement on the pathology of IgG4-related disease2012

    • Author(s)
      Deshpande V, Zrn Y, Nakanuma
    • Journal Title

      Mod Pathol

      Volume: 25(9) Pages: 1181-92

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinidal diagnostic criteria of IgG4-related sclerosing cholangitis 20122012

    • Author(s)
      Ohara H, Okazaki K, Tsubouchi H, Nakanuma Y
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 25(12) Pages: 1584-93

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Investigations of IgG4-related disease involving the skin2012

    • Author(s)
      Yamada K, Hamaguchi Y, Saeki T, Nakanuma Y
    • Journal Title

      Mod Rheumatol

      Volume: -

    • NAID

      10031201158

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] IgG4関連膵胆道疾患の診断と治療. IgG4関連膵胆道疾患の病理2013

    • Author(s)
      中沼安二.
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      グランドプリンスホテル新高輪,東京(基調講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] IgG4関連硬化性胆管炎に見られるBilIN病変の解析2013

    • Author(s)
      原田憲一、佐藤保則、中沼安二
    • Organizer
      第49回日本胆道学会学術集会
    • Place of Presentation
      ヒルトン東京ベイ,千葉(一般演題)
    • Related Report
      2013 Final Research Report
  • [Presentation] Hilar cholangiocarcinoma resembles pancreatic duct adenocarcinoma pathologically - Suggestions of similar background and development -2013

    • Author(s)
      Nakanuma Y
    • Organizer
      Asian IAP
    • Place of Presentation
      Busan Convention Center, Busan, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] IgG4関連硬化性胆管炎に出現するBiliary intraepithelial neoplasia (BiIIN)病変2013

    • Author(s)
      原田憲一、佐藤保則、中沼安二
    • Organizer
      第49回日本肝癌研究会
    • Place of Presentation
      京王プラザホテル,東京(一般演題)
    • Related Report
      2013 Final Research Report
  • [Presentation] IgG4関連疾患の肝病変. IgG4関連疾患に見られる末梢肝組織病変2013

    • Author(s)
      原田憲一、中沼安二
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル,東京(ワークショップ)
    • Related Report
      2013 Final Research Report
  • [Presentation] IgG4 rection in biliary intraepithelial neoplasia and cholangiocarcinoma arising from sclerosing cholangitis2013

    • Author(s)
      Harada K, Sato Y, Sato H, Ikeda H, Nakanuma Y.
    • Organizer
      The 102nd USCAP ANNUAL MEETING
    • Place of Presentation
      Baltimore Convention Center,Baltimore, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Pathological Differences between IgG4-Related Sclerosing Cholansitis with and without Autoimmune Pancreatitis2013

    • Author(s)
      Harada K, Nakanuma Y
    • Organizer
      The 102nd USCAP ANNUAL MEETING
    • Place of Presentation
      Baltimore Convention Center,Baltimore, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 自己免疫性膵炎合併の有無からみたIgG4硬化性胆管炎の病態の違い2013

    • Author(s)
      原田憲一、中沼安二
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      城山観光ホテル、鹿児島県
    • Related Report
      2012 Research-status Report
  • [Presentation] 硬化性胆管炎の病理学的多様性2012

    • Author(s)
      原田憲一、中沼安二
    • Organizer
      第48回日本胆道学会学術集会
    • Place of Presentation
      京王プラザホテル、東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 硬化性胆管炎からの発癌過程におけるIgG4反応の意義2012

    • Author(s)
      原田憲一、佐藤保則、中沼安二
    • Organizer
      第44回日本臨床分子形態学会 総会・学術集会
    • Place of Presentation
      高知市文化プラザかるぽーと、高知県
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性胆管炎に合併するBillN,胆管癌におけるIgG4組織反応2012

    • Author(s)
      原田憲一、佐藤保則、中沼安二
    • Organizer
      第16回日本肝臓学会大会
    • Place of Presentation
      神戸国際展示場、兵庫県
    • Related Report
      2012 Research-status Report
  • [Presentation] Hilar cholangiocarcinoma resembles pancreatic duct adenocarcinoma pathologically - Suggestions of similar background and development -

    • Author(s)
      Nakanuma Y.
    • Organizer
      Asian IAP
    • Place of Presentation
      Busan Convention Center, Busan, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] IgG4関連疾患の肝病変. IgG4関連疾患に見られる末梢肝組織病変.

    • Author(s)
      原田 憲一、 中沼 安二
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] IgG4関連硬化性胆管炎に出現するBiliary intraepithelial neoplasia (BiIIN) 病変

    • Author(s)
      原田 憲一、 佐藤 保則、 中沼 安二
    • Organizer
      第49回日本肝癌研究会
    • Place of Presentation
      京王プラザホテル, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] IgG4関連硬化性胆管炎に見られるBilIN病変の解析

    • Author(s)
      原田 憲一、 佐藤 保則、 中沼 安二
    • Organizer
      第49回日本胆道学会学術集会
    • Place of Presentation
      ヒルトン東京ベイ, 千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] IgG4関連膵胆道疾患の診断と治療. IgG4関連膵胆道疾患の病理

    • Author(s)
      中沼 安二
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      グランドプリンスホテル新高輪, 東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] IgG4-Related Disease. Sclerosing Cholangitis.2014

    • Author(s)
      Harada K, Nakanuma Y
    • Total Pages
      200
    • Publisher
      Springer Japan
    • Related Report
      2013 Annual Research Report
  • [Book] 肝臓を診る医師のための肝臓病理テキスト2013

    • Author(s)
      中沼安二
    • Total Pages
      315
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] IgG4-Related Disease. Sclerosing Cholangitis2013

    • Author(s)
      Harada K, Nakanuma Y
    • Publisher
      Springer Japan
    • Related Report
      2013 Final Research Report
  • [Book] 肝臓を診る医師のための肝臓病理テキスト2013

    • Author(s)
      中沼 安二
    • Total Pages
      315
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] IgG4関連疾患アトラス2012

    • Author(s)
      原田憲一 中沼安二
    • Total Pages
      200
    • Publisher
      株式会社前田書店
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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