| Project/Area Number |
24659163
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
YASUI Wataru 広島大学, 医歯薬保健学研究院(医), 教授 (40191118)
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| Co-Investigator(Renkei-kenkyūsha) |
OUE Naohide 広島大学, 大学院医歯薬保健学研究院, 准教授 (60346484)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ncRNA / 超保存領域（T-UCR) / 消化管癌 / 診断・治療展開 / 発現制御 / メチル化 / 非翻訳RNA / 超保存領域（T-UCR） |
|---|
| Research Abstract |
Transcribed ultraconserved region (T-UCR) transcripts are a novel class of long non-coding RNAs transcribed from ultraconserved regions (UCRs). The expression analysis of T-UCR in digestive tract cancers demonstrated that, in gastric cancer, most of T-UCRs including UCR118+A and 158+A were down-regulated by methylation, whereas UCR416+A and 420+A were overexpressed. Down-regulation of miR-148 and miR-143/-145 participated in cancer invasion and morphogenesis with interaction with stromal cells and served as prognostic factor of gastric cancer patients.
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