nalysis of non-coding RNAs transcribed from ultraconserved regions in digestive tract cancer and its diagnostic and therapeutic application
Project/Area Number |
24659163
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Human pathology
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Research Institution | Hiroshima University |
Principal Investigator |
YASUI Wataru 広島大学, 医歯薬保健学研究院(医), 教授 (40191118)
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Co-Investigator(Renkei-kenkyūsha) |
OUE Naohide 広島大学, 大学院医歯薬保健学研究院, 准教授 (60346484)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | ncRNA / 超保存領域(T-UCR) / 消化管癌 / 診断・治療展開 / 発現制御 / メチル化 / 非翻訳RNA / 超保存領域(T-UCR) |
Research Abstract |
Transcribed ultraconserved region (T-UCR) transcripts are a novel class of long non-coding RNAs transcribed from ultraconserved regions (UCRs). The expression analysis of T-UCR in digestive tract cancers demonstrated that, in gastric cancer, most of T-UCRs including UCR118+A and 158+A were down-regulated by methylation, whereas UCR416+A and 420+A were overexpressed. Down-regulation of miR-148 and miR-143/-145 participated in cancer invasion and morphogenesis with interaction with stromal cells and served as prognostic factor of gastric cancer patients.
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Report
(3 results)
Research Products
(64 results)
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[Journal Article] High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer2014
Author(s)
Oue N, Anami K, Schetter AJ, Moehler M, Okayama H, Khan MA, Bowman ED, Mueller A, Schad A, Shimomura M, Hinoi T, Aoyagi K, Sasaki H, Okajima M, Ohdan H, Galle PR, Yasui W and Harris CC
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Journal Title
Int J Cancer
Volume: 134
Pages: 1926-1934
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[Journal Article] Signal peptidase complex 18, encodes by SEC11A, contributes to progression via TGF-a secretion in gastric cancer2013
Author(s)
Naohide Oue, Yutaka Naito, Tetsutaro Hayashi, Misato Takigahira, Akiko Kawano-Nagatsuma, Kazuhiro Sentani, Naoya Sakamoto, Htoo Zarni Oo, Naohiro Uraoka, Kazuyoshi Yanagihara, Atsushi Ochiai, Hiroki Sasaki, Wataru Yasui
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Journal Title
Oncogene
Volume: 33
Issue: 30
Pages: 3918-3926
DOI
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Peer Reviewed / Open Access
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[Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice2012
Author(s)
Hayashi D, Tamura A, Tanaka H, Yamazaki Y, Watanabe S, Suzuki K, Suzuki K, Sentani K, Yasui W, Rakugi H, Isaka Y and Tsukita S
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Journal Title
Gastroenterology
Volume: 142
Pages: 292-304
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[Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer2012
Author(s)
Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Oo HZ, Naito Y, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H and Yasui W
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Journal Title
Cancer Sci
Volume: 103
Pages: 1744-1750
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[Journal Article] MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma.2012
Author(s)
Shinmei S, Sakamoto N, Goto K, Sentani K, Anami K, Hayashi T, Teishima J, Matsubara A, Oue N, Kitadai Y, Yasui W.
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Journal Title
Int J Urol
Volume: -
Issue: 5
Pages: 468-477
DOI
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Peer Reviewed
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[Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer2012
Author(s)
Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Naito Y, Oo HZ, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H, Yasui W.
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Journal Title
Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer
Volume: 103(9)
Issue: 9
Pages: 1744-50
DOI
Related Report
Peer Reviewed
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[Journal Article] Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-a secretion in gastric cancer
Author(s)
Oue N, Naito Y, Hayashi T, Takigahira M, Kawano-Nagatsuma A, Sentani K, Sakamoto N, Oo HZ, Uraoka N, Yanagihara K, Ochiai A, Sasaki H and Yasui W
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Journal Title
Oncogene
Volume: (In press)
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[Presentation] miR-148a, down-regulated in gastric cancer, targets MMP7 and participates in tumor invasion and poor prognosis2013
Author(s)
Sakamoto N, Naito Y, Oue N, Sentani K, Uraoka N, Oo HZ, Yanagihara K, Aoyagi K, Sasaki H and Yasui W
Organizer
10^<th> International Gastric Cancer Congress
Place of Presentation
Verona (Italy)
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