Development of diagnostic agent for dementia
| Project/Area Number |
24659169
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
ISHIGAMI Akihito 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50270658)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 認知症 / 臨床検査試薬 / アルツハイマー病 / 老化 / シトルリン化タンパク質 |
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| Outline of Final Research Achievements |
Peptidylarginine deiminases (PADs) are post-translational modification enzymes that citrullinate protein arginine residues. Abnormal protein citrullination by PAD2 has been closely associated with the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). In this study, we tried to develop a novel method for sandwich enzyme-linked immunosorbent assay (ELISA) for the determination of citrullinated proteins which may become a useful marker of human neurodegenerative diseases.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Peptidylarginine deiminase and protein citrullination in prion diseases: Strong evidence of neurodegeneration.2013
Author(s)
Jang, B., Ishigami, A., Maruyama, N., Carp, R.I., Kim, Y.S., Choi, E.K.
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Journal Title
Prion
Volume: 7
Issue: 1
Pages: 42-46
DOI
Related Report
Peer Reviewed
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[Journal Article] Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis.2013
Author(s)
Ishigami, A., Uchida, Y., Miyazaki, T., Handa, S., Choi, E.K,, Kim, Y.S,, Kasahara, Y., Maruyama, N.
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Journal Title
Mod Rheumatol.
Volume: 23
Issue: 4
Pages: 794-803
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Age-related changes of peptidylarginine deiminase 2 in the mouse brain.2013
Author(s)
Kagami, Y., Shimada, N., Handa, S., Choi, E.K., Kim, Y.S., Ito, H., Maruyama, N., Ishigami, A.
Organizer
The 20th IAGG World Congress of Gerontology and Geriatrics (IAGG 2013)
Place of Presentation
Seoul, Korea
Related Report
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[Presentation] Peptidylarginine deiminase 2-mediat ed protein citrullinati on in prion disease.2013
Author(s)
Kim, H.J., Jang, B., Jin, J.K., Jeon, Y.C., Ishigami, A., Maruyama, N., Carp, R.I., Kim, Y.S., Choi, E.K.
Organizer
The 20th IAGG World Congress of Gerontology and Geriatrics (IAGG 2013)
Place of Presentation
Seoul, Korea
Related Report
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[Book] Deimination in Prion Diseases. In: Protein Deimination in Human Health and Disease.2014
Author(s)
Choi, E.K., Jang, B., Ishigami, A., Maruyama, N., Carp, R.I.,Kim, Y.K.
Total Pages
433
Publisher
Springer
Related Report
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