Role of a 2-oxoglutarate and iron-dependent oxygenase OGFOD1 in cancer
| Project/Area Number |
24659170
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Aichi Cancer Center Research Institute |
|---|
Principal Investigator |
SAITO Ken 愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (70426584)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONDO Eisaku 新潟大学, 医学部・実験病理, 教授 (30252951)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 水酸化酵素 / がん増殖 |
|---|
| Outline of Final Research Achievements |
OGFOD1 catalyzes hydroxylation of ribosomal protein RPS23 and play a role in the regulation of translation, as recently suggested by several groups. However, functional role and relevance to cancer are poorly understood. In this report, we found that OGFOD1 was primarily a nuclear protein in many cancer cells and highly expressed in cancer tissues including esophageal squamous cell carcinoma. Knock-down of OGFOD1 suppressed cellular proliferation through up-regulation of p21cip1 and cell-cycle arrest. Furthermore CDK inhibitor (Albocidib) affected OGFOD1 expression and cellular growth.These results support that the induction of OGFOD1 is necessary for the cell growth and cell-cycle of malignant tumor.
|
Report
(4 results)
Research Products
(2 results)
