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Role of a 2-oxoglutarate and iron-dependent oxygenase OGFOD1 in cancer

Research Project

Project/Area Number 24659170
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

SAITO Ken  愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (70426584)

Co-Investigator(Kenkyū-buntansha) KONDO Eisaku  新潟大学, 医学部・実験病理, 教授 (30252951)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords水酸化酵素 / がん増殖
Outline of Final Research Achievements

OGFOD1 catalyzes hydroxylation of ribosomal protein RPS23 and play a role in the regulation of translation, as recently suggested by several groups. However, functional role and relevance to cancer are poorly understood. In this report, we found that OGFOD1 was primarily a nuclear protein in many cancer cells and highly expressed in cancer tissues including esophageal squamous cell carcinoma. Knock-down of OGFOD1 suppressed cellular proliferation through up-regulation of p21cip1 and cell-cycle arrest. Furthermore CDK inhibitor (Albocidib) affected OGFOD1 expression and cellular growth.These results support that the induction of OGFOD1 is necessary for the cell growth and cell-cycle of malignant tumor.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2015 2013

All Presentation (2 results)

  • [Presentation] 悪性腫瘍におけるOGFOD1の役割2015

    • Author(s)
      齋藤 憲
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロリン水酸化酵素ファミリー OGFOD1の発現解析2013

    • Author(s)
      齋藤 憲
    • Organizer
      日本病理学会
    • Place of Presentation
      北海道
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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