New developments in mitochondrial study to overcome
| Project/Area Number |
24659174
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUWAHARA Yoshikazu 東北大学, 加齢医学研究所, 助教 (00392225)
SHIMURA Tsutomu 国立保健医療科学院, 生活環境研究部, 上席主任研究官 (40463799)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 臨床的放射線耐性 / がん細胞 / ミトコンドリア / ワールブルグ効果 / 活性酸素種(ROS) / X線 / ドセタキセル / カタラーゼ / 電子伝達系 / 活性酸素 |
|---|
| Research Abstract |
Mitochondrial reactive oxygen species (ROS) was detectable in parental cells but not in clinically relevant radioresistant (CRR) cells after 10 Gy of X-ray irradiation or 100 ng/ml of docetaxel (DTX) treatment. We established cells resistant to H2O2 and they revealed to be resistant both to X-rays and DTX. Mitochondrial DNA depleted rho0 cells were also established. They were resistant both to X-ray irradiation and DTX treatment without ROS production. Theses suggest that ROS derived from mitochondria are involved in the CRR phenotype and DTX resistance.
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Report
(3 results)
Research Products
(60 results)
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[Journal Article] Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production.2013
Author(s)
Sakurai T, Kudo M, Watanabe T, Itoh K, Higashitsuji H, Arizumi T, Inoue T, Hagiwara S, Ueshima K, Nishida N, Fukumoto M, Fujita J.
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Journal Title
Dig Dis
Volume: 31
Issue: 5-6
Pages: 440-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Distribution of artificial radionuclides in abandoned cattle in theeva cuation zone of the Fukushima Daiichi nuclear power plant2013
Author(s)
Fukuda T, Kino Y, Abe Y, Yamashiro H, Kuwahara Y, Nihei H, Sano Y, Irisawa A, Shimura T, Fukumoto M, Shinoda H, Obata Y, Saigusa S, Sekine T, Isogai E, Fukumoto M.
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Journal Title
PLoS One
Volume: 8(1)
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident2013
Author(s)
Yamashiro, H., Abe, Y., Fukuda, T., Kino, Y., Kuwahara, Y., Fukumoto, M., Kobayashi, J., Uematsu, E., Tong, B., Sugiyama, T., Yamada, T., Shinoda, H., Sekine, T., Sato, E.
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Journal Title
Sci. Rep.
Volume: (掲載決定)
Issue: 1
Pages: 2850-2856
DOI
Related Report
Peer Reviewed
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