Pathogen eradication mediated by receptor for IgM natural antibody

• Project/Area Number: 24659175
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: University of Tsukuba
• Principal Investigator: HONDA Shinichiro 筑波大学, 医学医療系, 准教授 (60360640)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Fc受容体 / 自然抗体 / 敗血症 / IgA / IgM

Research Abstract

Natural IgM antibody recognizes various pathogen components and contributes to eradication of pathogens. We found that mice lacking IgM Fc receptor, Fca/mR (CD351), showed reduced inflammatory cytokines production against lipopolysaccharide (LPS) and improved survival against septic shock. We also found that marginal zone B cells (MZBs), highly expressing Fca/mR, largely contribute inflammatory cytokines production against LPS. Thus, Fca/mR regulates inflammatory cytokine production from MZB, leading to the regulation of systemic inflammatory responses during LPS-induced septic shock.

Research Products

• [Journal Article] Involvement of Fcα/μR (CD351) in autoantibody production (2013)
  • Author(s): Yoshizawa Y, Honda S, Shibuya A
  • Journal Title: Mol Immunol Volume: 57(2) Issue: 2 Pages: 216-219
  • DOI: 10.1016/j.molimm.2013.10.002
  • NAID: 120007130578
  • Peer Reviewed
• [Journal Article] Molecular characterization of the dimer formation of Fcα/μ receptor (CD351) (2013)
  • Author(s): Takagaki K, Satoh K, Honda S, Shibuya A
  • Journal Title: Mol Immunol Volume: 56(1-2) Issue: 1-2 Pages: 23-27
  • DOI: 10.1016/j.molimm.2013.04.003
  • NAID: 120007136867
  • Peer Reviewed
• [Journal Article] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells (2013)
  • Author(s): Arai, S., et al.
  • Journal Title: Cell Rep. Volume: 3 Issue: 4 Pages: 1-12
  • DOI: 10.1016/j.celrep.2013.03.006
  • Peer Reviewed
• [Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. (2012)
  • Author(s): Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S. and Shibuya, A.
  • Journal Title: J Exp. Med. Volume: 209 Issue: 8 Pages: 1493-1503
  • DOI: 10.1084/jem.20120096
  • Peer Reviewed
• [Journal Article] Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor (2012)
  • Author(s): Chigusa Nakahashi-Oda, et.al.
  • Journal Title: BBRC Volume: 417 Issue: 1 Pages: 646-650
  • DOI: 10.1016/j.bbrc.2011.12.025
  • Peer Reviewed
• [Presentation] Involvement of CD300a in the pathogenesis of DSS-induced colitis (2013)
  • Author(s): Totsuka N, Kim YG, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会
  • Place of Presentation: 学術集会幕張メッセ(千葉)
  • Year and Date: 2013-12-13
• [Presentation] Fcα/μR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock (2013)
  • Author(s): Honda S, Yoshizawa Y, Sato K, Fujimoto M, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会
  • Place of Presentation: 学術集会幕張メッセ(千葉)
  • Year and Date: 2013-12-12
• [Presentation] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells (2013)
  • Author(s): Arai S, Honda S, Shibuya A, Li Q-Z, Miyazaki T.
  • Organizer: 第42回日本免疫学会総会
  • Place of Presentation: 学術集会幕張メッセ(千葉)
  • Year and Date: 2013-12-11
• [Presentation] Fcα/μR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock (2013)
  • Author(s): Honda S, Satoh K, Matsuoka Y, Matsushita T, Fujimoto M, Shibuya A.
  • Organizer: 15^<th> International Congress of Immunology
  • Place of Presentation: Mico Milano Congressi, Milan, Italy
  • Year and Date: 2013-08-23
• [Presentation] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor (2012)
  • Author(s): Nakahashi-Oda C, Tahara-Hanaoka S, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A.
  • Organizer: 第41回日本免疫学会国際シンポジウム(41^<th> International Symposium of Japanese Society of immunology, Kobe.)
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2012-12-06
• [Presentation] Follicular dendritc cells (FDC) internalized IgM-coated antigen via Fc receptor for IgA/IgM (Fcα/μR; CD351) (2012)
  • Author(s): Sato K, Usui K, Honda S, Yoshizawa Y, Shibuya A.
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2012-12-05
• [Presentation] Follicular dendritc cells (FDC) internalized IgM-coated antigen via Fc receptor for IgA/IgM (Fcα/μR; CD351) (2012)
  • Author(s): Sato K
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock.
  • Author(s): Honda S, Satoh K, Matsuoka Y, Matsushita T, Fujimoto M, Shibuya A.
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Mico Milano Congressi, Milan, Italy
• [Presentation] Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock.
  • Author(s): Honda S, Yoshizawa Y, Sato K, Fujimoto M, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Involvement of CD300a in the pathogenesis of DSS-induced colitis.
  • Author(s): Totsuka N, Kim YG, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells
  • Author(s): Arai S, Honda S, Shibuya A, Li Q-Z, Miyazaki T..
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Remarks] つくばリポジトリ
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/simple-search?query=%E6%9C%AC%E5%A4%9A+%E4%BC%B8%E4%B8%80%E9%83%8E
• [Remarks] TRIOS
  • URL: http://trios.tsukuba.ac.jp/researcher/0000001684
• [Remarks] つくばリポジトリ
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/simple-search?query=%E6%9C%AC%E5%A4%9A+%E4%BC%B8%E4%B8%80%E9%83%8E
• [Remarks] TRIOS
  • URL: http://trios.tsukuba.ac.jp/researcher/0000001684