Development of the novel molecular target therapy for the graft versus host disease (GVHD) using the humanized mice
| Project/Area Number |
24659176
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分子標的 / 移植片対宿主病 / 骨髄移植 / ヒト化マウス / 免疫応答制御 |
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| Research Abstract |
We have previously demonstrated that DNAM-1 plays an important role in the development of GVHD in a mouse model and is an ideal molecular target for therapeutic approaches to GVHD.
In this project, to investigate whether the administration of anti-human DNAM-1 antibodies ameliorates human GVHD, we have generated humanized mice expressing the human DNAM-1 ligand, CD155. For this experiment, we established 87 anti-human DNAM-1 monoclonal antibodies.
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Report
(3 results)
Research Products
(56 results)
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[Journal Article] Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice2012
Author(s)
Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S
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Journal Title
Eur J Immunol
Volume: 42
Issue: 8
Pages: 1999-2009
DOI
Related Report
Peer Reviewed
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[Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.2012
Author(s)
Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S. and Shibuya, A.
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Journal Title
J Exp. Med.
Volume: 209
Issue: 8
Pages: 1493-1503
DOI
Related Report
Peer Reviewed
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