Identification of immunogenic nucleic acid-protein complex

• Project/Area Number: 24659177
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: The University of Tokyo
• Principal Investigator: NEGISHI Hideo 東京大学, 生産技術研究所, 特任助教 (60514297)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 免疫性核酸 / 炎症 / RNA / 核酸

Research Abstract

In my previous study, I isolated chemical compounds which bound to nucleic acid. Some of them had strong therapeutic effect on inflammatory diseases in the mice model. From this and other results, I hypothesized that the compounds targeted the endogenous immunogenic nucleic acid-protein complex. In this study, I tried to identify them and successfully identified both immunogenic nucleic acid and protein. Further study may provide the new strategy for the therapy of inflammatory diseases.