| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
This study was designed to clarify the involvement of oxidative stress and oxidized proteins on Down syndrome. Overexpression of fatty acid binding protein was observed in the brain tissue of Ts65Dn mouse, a Down syndrome model mouse, by using MALDI-imaging. And the increase of oxidized DJ-1 protein in RBC of Ts65Dn mice. It was demonstrated that the open arm ratio on elevated plus maze task was increased in Ts65Dn mouse with their weeks of age. Chronic supplementation with α-tocopherol from the embryonic stage improved this open arm ratio of Ts65Dn mice. These results indicated that oxidative stress invulved in the impairment of this mouse.
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