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Live imaging of experimental cerebral malaria

Research Project

Project/Area Number 24659189
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Parasitology (including Sanitary zoology)
Research InstitutionNagasaki University

Principal Investigator

YUI Katsuyuki  長崎大学, 医歯(薬)学総合研究科, 教授 (90274638)

Co-Investigator(Renkei-kenkyūsha) TAMURA Takahiko  長崎大学, 大学院医歯薬学総合研究科, 助教 (00434035)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsマラリア / イメージング / 感染 / 脳 / T細胞 / 原虫 / マウス
Research Abstract

I planned to investigate the cellular mechanisms underlying the pathogenesis of experimental cerebral malaria using 3 imaging techniques; luciferase imaging, fluorescence imaging using multiphoton microscope, and PET/CT imaging. I was able to get enough information and preparation for the analysis using these techniques.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (44 results)

All 2014 2013 2012 Other

All Journal Article (18 results) (of which Peer Reviewed: 9 results) Presentation (23 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Flt3 ligand treatment modulates rodent parasitemia infection via MyD88 and IFN-g-dependent mechanisms2014

    • Author(s)
      Tamura, T, Akbari, M., Kimura K., Kimura, D., Yui, K.
    • Journal Title

      Parasite Immunol

      Volume: 36 Pages: 87-99

    • Related Report
      2013 Final Research Report
  • [Journal Article] Flt3 ligand treatment modulates parasitemia during infection with rodent malaria parasites via MyD88- and IFN-γ-dependent mechanisms.2014

    • Author(s)
      Takahiko Tamura, Masoud Akbari, Kazumi Kimura, Daisuke Kimura and Katsuyuki Yui
    • Journal Title

      Parasite Immunology

      Volume: 36 Issue: 2 Pages: 87-99

    • DOI

      10.1111/pim.12085

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.2014

    • Author(s)
      Akbari Masoud, Kiri Honma, Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Toshifumi Matsuyama, Katsuyuki Yui
    • Journal Title

      Journal of Immunology

      Volume: 192 Issue: 5 Pages: 2271-2279

    • DOI

      10.4049/jimmunol.1301914

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD8^+ T cells specific for a malaria cytoplasmic antigen form clusters around infected hepatocytes and are protective at the liver stage of infection2013

    • Author(s)
      Kimura, K., Kimura, D., Matsushima, Y., Miyakoda, M., Honma, K., Yuda, M., Yui, K.
    • Journal Title

      Inf. Immun

      Volume: 81(10) Pages: 3825-3834

    • NAID

      120006986085

    • Related Report
      2013 Final Research Report
  • [Journal Article] CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model2013

    • Author(s)
      Bao, L.Q., Huy, N.T., Kikuchi, M., Yanagi, T., Senba, M., Shuaibu, M.N., Honma, K., Yui, K., Hirayama, K.
    • Journal Title

      PLos One

      Volume: 8(5)

    • NAID

      120006986217

    • Related Report
      2013 Final Research Report
  • [Journal Article] Closeup : Cross-presentation of malaria antigen by brain microvessels : why CD8^+ T cells are critical for the pathogeneisis of cerebral malaria2013

    • Author(s)
      Yui,K.
    • Journal Title

      EMBO Mol. Med

      Volume: 5(7) Pages: 899-901

    • Related Report
      2013 Final Research Report
  • [Journal Article] Accumulation of MHC class II^+ CD11c^- non-lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte-dependent2013

    • Author(s)
      Kamei, R., Miyakoda, M., Tamura, T., Kimura, D., Honma, K., Kimura, K., Yui, K.
    • Journal Title

      Microbiol. Immunol

      Volume: 57(3) Pages: 213-223

    • Related Report
      2013 Final Research Report
  • [Journal Article] Closeup: Cross-presentation of malaria antigen by brain microvessels: why CD8+ T cells are critical for the pathogeneisis of cerebral malaria.2013

    • Author(s)
      Yui,K.
    • Journal Title

      EMBO Mol. Med.

      Volume: 5 Issue: 7 Pages: 899-901

    • DOI

      10.1002/emmm.201302849

    • Related Report
      2013 Annual Research Report
  • [Journal Article] CD8+ T cells specific for a malaria cytoplasmic antigen form clusters around infected hepatocytes and are protective at the liver stage of infection.2013

    • Author(s)
      Kazumi Kimura, Daisuke Kimura, Yoshifumi Matsushima, Mana Miyakoda, Kiri Honma, Masao Yuda, and Katsuyuki Yui
    • Journal Title

      Infection of Immunology

      Volume: 81 Issue: 10 Pages: 3825-3834

    • DOI

      10.1128/iai.00570-13

    • NAID

      120006986085

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.2013

    • Author(s)
      Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, et al.
    • Journal Title

      J Immunol.

      Volume: 191 Issue: 5 Pages: 2360-2371

    • DOI

      10.4049/jimmunol.1301276

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of memory CD8^+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA2012

    • Author(s)
      Miyakoda, M., Kimura, D. , Honma, K., Kimura, K., Yuda, M., Yui, K.
    • Journal Title

      J. Immunol

      Volume: 189(9) Pages: 4396-4404

    • Related Report
      2013 Final Research Report
  • [Journal Article] The species specificity of immunity generated by live whole organism immunization with erythrocytic and pre-erythrocytic stages of rodent malaria parasites and implications for vaccine development2012

    • Author(s)
      Inoue M., Jianxia T., Miyakoda M., Kaneko O., Yui, K., Culleton R.
    • Journal Title

      Int. J. Parasitol

      Volume: 42 Pages: 859-870

    • Related Report
      2013 Final Research Report
  • [Journal Article] Platelets presents antigen in the context of MHC class I2012

    • Author(s)
      Chapman, L.M., Aggrey, A.A., Field, D.J., Srivastava, K., Ture S., Yui, K., Topham, D.J., Baldwin III, W,M., Morell, C.N.
    • Journal Title

      J. Immunol

      Volume: 189(2) Pages: 916-923

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of memory CD8+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA.2012

    • Author(s)
      Miyakoda M, Kimura D, Honma K, Kimura K. Yuda M, Yui K,
    • Journal Title

      The Journal of Immunology

      Volume: 189 Issue: 9 Pages: 4396-4404

    • DOI

      10.4049/jimmunol.1200781

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Platelets presents antigen in the context of MHC class I2012

    • Author(s)
      Chapman, L.M., Aggrey, A.A., Field, D.J., Srivastava, K., Ture S., Yui, K., Topham, D.J., Baldwin III, W,M., Morell, C.N.
    • Journal Title

      J. Immunol.

      Volume: 189 Issue: 2 Pages: 916-923

    • DOI

      10.4049/jimmunol.1200580

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The species specificity of immunity generated by live whole organismimmunization with erythrocytic and pre-erythrocytic stages of rodent malaria parasites and implications for vaccine development2012

    • Author(s)
      井上 愛美
    • Journal Title

      International Journal for Parasitology

      Volume: 42 Issue: 9 Pages: 859-870

    • DOI

      10.1016/j.ijpara.2012.07.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dengue virus strain DEN2 16681 utilizes a specific glycochain of syndecan-2 proteoglycan as a receptor2012

    • Author(s)
      Okamoto K, その他8名
    • Journal Title

      Journal of General Virology

      Volume: 93 Issue: 4 Pages: 761-770

    • DOI

      10.1099/vir.0.037853-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phenotypic analysis of monocyte-derived dendritic cells loaded with tumor antigen with heat-shock cognate protein-70.2012

    • Author(s)
      Ito S., Nagata Y., Susumu S., Yoneda A, Matsuo M., Yui K., Udono H. Eguchi S and Kanematsu T.
    • Journal Title

      Anticancer Res.

      Volume: 32 Pages: 4897-4904

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] T cell responses during infection with Plasmodium berghei ANKA2014

    • Author(s)
      K. Yui
    • Organizer
      Mini symposium on malaria immunopathology, IFReC
    • Place of Presentation
      吹田市
    • Year and Date
      2014-01-15
    • Related Report
      2013 Final Research Report
  • [Presentation] マラリア原虫特異的CD4^+ T細胞は、IL-27を介してCD4^+ T細胞の防御機能を抑制する2014

    • Author(s)
      木村大輔、都田真奈、木村一美,本間季里、原博満、堀昌平、吉田裕樹、由井克之
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      松山市
    • Related Report
      2013 Final Research Report
  • [Presentation] 赤血球期マウスマラリア原虫感染における従来型樹状細胞の減少はI型、II型インターフェロン依存的細胞死である2014

    • Author(s)
      田村隆彦、木村一美、由井克之、吉田栄人
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      松山市
    • Related Report
      2013 Final Research Report
  • [Presentation] T cell responses during infection with Plasmodium berghei ANKA2014

    • Author(s)
      由井克之、木村一美、都田真奈、木村大輔、油田正夫
    • Organizer
      Mini symposium on malaria immunopathology
    • Place of Presentation
      吹田市大阪大学IFrec
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マラリア原虫特異的CD4+ T細胞は、IL-27を介してCD4+ T細胞の防御機能を抑制する2014

    • Author(s)
      木村大輔、都田真奈、木村一美、本間季里、原博満、堀昌平、吉田裕樹、由井克之
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      松山市愛媛大学城北キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-27 is produced by CD4^+T cells during infection with malaria parasites and inhibits protective immune responses2013

    • Author(s)
      KIMURA D, MIYAKODA M, KIMURA K, HONMA K, HARA H, HORI S, YOSHIDA H, YUI K
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Final Research Report
  • [Presentation] CD8 ^+T cells form clusters around infected hepatocytes protecting against liver-stage infextion with plasmodium berghei ANKA2013

    • Author(s)
      KIMURA K, KIMURA D, MIYAKODA M, YUI K
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Final Research Report
  • [Presentation] Flt3 ligand treatment inhibits parasitemia during infection with rodent malaria parasites via MyD88-and IFN-g-dependent mechanisms2013

    • Author(s)
      TAMURA T, KIMURA K, YUI K
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Final Research Report
  • [Presentation] CD8 + T細胞による肝細胞期マラリア原虫感染防御の生体イメージング2013

    • Author(s)
      由井克之、木村一美、都田真奈、木村大輔、油田正夫
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] マラリア原虫特異的CD4T細胞はEBI3陽性サイトカインを介して他のCD4T細胞のIL-2産生を制する2013

    • Author(s)
      木村大輔、都田真奈、本間季里、木村一美、原博満、吉田裕樹、由井克之
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] マラリア原虫感染における抗原特異的記憶CD8^+T細胞の二次応答抑制2013

    • Author(s)
      都田真奈、木村大輔、本間季里、木村一美、油田正夫、由井克之
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-27 is produced by CD4+ T cells during infection with malaria parasites and inhibits protective immune responses2013

    • Author(s)
      Kimura D, Miyakoda M, Kimura K, Honma K, Hara H, Hori S, Yoshida H, Yui K
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD8+ T cells form clusters around infected hepatocytes protecting against liver-stage infextion with plasmodium berghei ANKA2013

    • Author(s)
      Kimura K, Kimura D, Miyakoda M, YUI K
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Flt3 ligand treatment inhibits parasitemia during infection with rodent malaria parasites via MyD88-and IFN-g-dependent mechanisms2013

    • Author(s)
      Tamura T, Kimura K, Yui K
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD8+ T細胞による肝細胞期マラリア原虫感染防御の生体イメージング2013

    • Author(s)
      由井克之、木村一美、都田真奈、木村大輔、油田正夫
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] マラリア原虫特異的CD4T細胞はEBI3陽性サイトカインを介して他のCD4T細胞のIL-2産生を制する2013

    • Author(s)
      木村大輔、都田真奈、本間季里、木村一美、原博満、吉田裕樹、由井克之
    • Organizer
      第65回日本寄生虫学会南日本支部大会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] マラリア原虫感染における抗原特異的記憶CD8+T細胞の二次応答抑制2013

    • Author(s)
      都田真奈、木村大輔、本間季里、木村一美、油田正夫、由井克之
    • Organizer
      第65回日本寄生虫学会南日本支部大会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of memory CD8 + T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA2012

    • Author(s)
      M. Miyakoda, D. Kimura, K. Honma, K. Kimura, M. Yuda, K. Yui.
    • Organizer
      Immunological mechanisms of vaccination, Part of the Keystone sumposia global health series
    • Place of Presentation
      オタワ(カナダ)
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of T cell responses during infection with P. berghei ANKA leading to the protective immunity and pathogenesis of cerebral malaria2012

    • Author(s)
      D. Kimura, M. Miyakoda, K. Kimura, K. Yui
    • Organizer
      The 6^<th> Nagasaki symposium on tropical and emerging infectious diseases, The 11 th Nagasaki-Singapore medical symposium
    • Place of Presentation
      長崎市
    • Related Report
      2013 Final Research Report
  • [Presentation] CD4^+ T cells produce EBI-3^+ cytokine inhibiting their own protective immune responses during infection with malaria parasites2012

    • Author(s)
      D. Kimura, M. Miyakoda, Honma, K. Kimura, H. Hara, H. Yoshida, K. Yui
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Final Research Report
  • [Presentation] モデル抗原組換えマラリア原虫を用いた肝細胞期防御免疫機構の解析2012

    • Author(s)
      木村一美、木村大輔、都田真奈、本間季里、田村隆彦、油田正夫、由井克之
    • Organizer
      第65回日本寄生虫学会南日本支部大会
    • Place of Presentation
      兵庫医科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] CD4+ T cells produce EBI-3+ cytokine inhibiting their own protective immune responses during infection with malaria parasite2012

    • Author(s)
      D. Kimura, M. Miyakoda, Honma, K. Kimura, H. Hara, H. Yoshida, K. Yui
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of memory CD8+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA.2012

    • Author(s)
      M. Miyakoda, D. Kimura, K. Honma, K. Kimura, M. Yuda, K. Yui.
    • Organizer
      Keystone sumposia global health series
    • Place of Presentation
      カナダ オタワ市
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/mmi/im/

    • Related Report
      2013 Final Research Report
  • [Remarks] 長崎大学大学院医歯薬学総合研究科 免疫学分野

    • URL

      http://www.med.nagasaki-u.ac.jp/mmi/im/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 免疫機能制御学

    • URL

      http://www.med.nagasaki-u.ac.jp/mmi/im/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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