Live imaging of experimental cerebral malaria
Project/Area Number |
24659189
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Parasitology (including Sanitary zoology)
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Research Institution | Nagasaki University |
Principal Investigator |
YUI Katsuyuki 長崎大学, 医歯(薬)学総合研究科, 教授 (90274638)
|
Co-Investigator(Renkei-kenkyūsha) |
TAMURA Takahiko 長崎大学, 大学院医歯薬学総合研究科, 助教 (00434035)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | マラリア / イメージング / 感染 / 脳 / T細胞 / 原虫 / マウス |
Research Abstract |
I planned to investigate the cellular mechanisms underlying the pathogenesis of experimental cerebral malaria using 3 imaging techniques; luciferase imaging, fluorescence imaging using multiphoton microscope, and PET/CT imaging. I was able to get enough information and preparation for the analysis using these techniques.
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] CD8^+ T cells specific for a malaria cytoplasmic antigen form clusters around infected hepatocytes and are protective at the liver stage of infection2013
Author(s)
Kimura, K., Kimura, D., Matsushima, Y., Miyakoda, M., Honma, K., Yuda, M., Yui, K.
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Journal Title
Inf. Immun
Volume: 81(10)
Pages: 3825-3834
NAID
Related Report
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[Journal Article] CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model2013
Author(s)
Bao, L.Q., Huy, N.T., Kikuchi, M., Yanagi, T., Senba, M., Shuaibu, M.N., Honma, K., Yui, K., Hirayama, K.
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Journal Title
NAID
Related Report
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[Journal Article] Accumulation of MHC class II^+ CD11c^- non-lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte-dependent2013
Author(s)
Kamei, R., Miyakoda, M., Tamura, T., Kimura, D., Honma, K., Kimura, K., Yui, K.
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Journal Title
Microbiol. Immunol
Volume: 57(3)
Pages: 213-223
Related Report
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[Journal Article] Development of memory CD8^+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA2012
Author(s)
Miyakoda, M., Kimura, D. , Honma, K., Kimura, K., Yuda, M., Yui, K.
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Journal Title
J. Immunol
Volume: 189(9)
Pages: 4396-4404
Related Report
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[Journal Article] Platelets presents antigen in the context of MHC class I2012
Author(s)
Chapman, L.M., Aggrey, A.A., Field, D.J., Srivastava, K., Ture S., Yui, K., Topham, D.J., Baldwin III, W,M., Morell, C.N.
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Journal Title
J. Immunol
Volume: 189(2)
Pages: 916-923
Related Report
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[Journal Article] Platelets presents antigen in the context of MHC class I2012
Author(s)
Chapman, L.M., Aggrey, A.A., Field, D.J., Srivastava, K., Ture S., Yui, K., Topham, D.J., Baldwin III, W,M., Morell, C.N.
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Journal Title
J. Immunol.
Volume: 189
Issue: 2
Pages: 916-923
DOI
Related Report
Peer Reviewed
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