Analysis of mechanism of human herpesvirus-6-induced immune suppression

• Project/Area Number: 24659206
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Virology
• Research Institution: Kobe University
• Principal Investigator: MORI YASUKO 神戸大学, 医学(系)研究科(研究院), 教授 (50343257)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 分子 / 細胞 / ヘルペスウイルス / HHV-6 / CD6発現低下 / ウイルス / 免疫

Research Abstract

Primary infection and reactivation of HHV-6 have been reported to induce immunosuppression in host. The mechanism behind this phenomenon is unknown. We have identified the downregulation of CD6 on HHV-6-infected cells. Here we found that CD6 was dramatically downregulated at the late phase of infected cells, and we also searched for the viral genes responsible for this downregulation and found several genes which might be associated with this phenomenon. Our findings may contribute to elucidating the mechanism of immunosuppression induced by HHV-6 infection.

Research Products

• [Journal Article] Characterization of the human herpesvirus 6A U23 gene (2014)
  • Author(s): Hayashi, M., K. Yoshida, H. Tang, T. Sadaoka, A. Kawabata, C. Jasirwan, and Y. Mori.
  • Journal Title: Virology
  • Peer Reviewed
• [Journal Article] Characterization of the human herpesvirus 6A U23 gene. (2014)
  • Author(s): Hayashi, M., Yoshida, K., Tang, H., Sadaoka, T., Kawabata, A., Jasirwan, C., and Mori, Y.
  • Journal Title: Virology Volume: 450-451 Pages: 98-105
  • DOI: 10.1016/j.virol.2013.12.004
  • Peer Reviewed
• [Presentation] ヒトヘルペスウイルス6B感染により引き起こされる宿主因子の発現低下 (2013)
  • Author(s): 林麻佑子、河端暁子、湯華民、定岡知彦、森康子
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
• [Presentation] ヒトヘルペスウイルス6B感染による宿主細胞のシグナルと免疫抑制の解析 (2013)
  • Author(s): 林麻佑子、世良田聡、河端暁子、湯華民、定岡知彦、仲哲治、森康子
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県淡路市)
• [Presentation] ヒトヘルペスウイルス6B感染により引き起こされる宿主因子の発現低下 (2013)
  • Author(s): 林 麻佑子、河端 暁子、湯 華民、定岡 知彦、森 康子
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Human herpesvirus 6 U21 to U24 gene cluster is not essential for the virus growth (2013)
  • Author(s): Chyntia Jasirwan, Takahiro Maeki, Huamin Tang, Yasuko Mori
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸