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An alternative interferon inducing pathway predicted through phylogenetic analyses

Research Project

Project/Area Number 24659214
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionHokkaido University

Principal Investigator

SEYA Tsukasa  北海道大学, 医学(系)研究科(研究院), 教授 (10301805)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自然免疫 / パターン認識レセプター / インターフェロン
Research Abstract

Two membrane proteins having N-terminal extracellular domain Ig (immunoglobulin domain) and C-terminal Toll-IL-1 homology domain (TIR) were identified from the zebrafish database. We called these proteins Ig-TIR. We have cloned the cDNAs of these proteins and their functional properties were determined with overexpression and siRNA analysis using rainbow trout cell lines. We could not detect any activity affecting NF-kB activation, IFN induction or cytokine assays. We suppose that the Ig-TIR proteins have functions other than the known TLR proteins that sense microbial pattern molecules.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (45 results)

All 2014 2013 2012 2011 Other

All Journal Article (42 results) (of which Peer Reviewed: 24 results) Book (1 results) Remarks (2 results)

  • [Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection2014

    • Author(s)
      Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T.
    • Journal Title

      J Immunol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Beyond dsRNA : Toll-like receptor 3 signalling in RNA-induced immune responses2014

    • Author(s)
      Tatematsu M, Seya T, Matsumoto M.
    • Journal Title

      Biochem J

      Volume: 458(2) Pages: 195-201

    • Related Report
      2013 Final Research Report
  • [Journal Article] MAVS-dependent IRF3/7 bypass of interferonβ-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells2014

    • Author(s)
      Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T.
    • Journal Title

      Mol Immunol

      Volume: 57(2) Pages: 100-10

    • Related Report
      2013 Final Research Report
  • [Journal Article] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic : polycytidylic acid treatment in mouse tumor models2014

    • Author(s)
      Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T.
    • Journal Title

      J Innate Immun

      Volume: 6 Pages: 293-305

    • Related Report
      2013 Final Research Report
  • [Journal Article] Assessment of the Toll-like receptor 3 pathway in endosomal signaling2014

    • Author(s)
      Matsumoto M, Funami K, Tatematsu M, Azuma M, Seya T.
    • Journal Title

      Methods Enzymol

      Volume: 535 Pages: 149-65

    • Related Report
      2013 Final Research Report
  • [Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepetocytes and bendritic Cells in Response to Hepatitis C Virus Infection.2014

    • Author(s)
      Masaaki Okamoto, et al.
    • Journal Title

      Journal of immunology

      Volume: 192 Issue: 6 Pages: 2770-7

    • DOI

      10.4049/jimmunol.1301459

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beyond double-stranded RNA : TLR3 signaling in RNA-induced immune responses2014

    • Author(s)
      Tatematsu, M., T. Seya, M. Matsumoto
    • Journal Title

      Biochem. J

      Volume: 458 Issue: 2 Pages: 195-201

    • DOI

      10.1042/bj20131492

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Ta mouse bone marrow-derived dendritic cells.2014

    • Author(s)
      Hiromi Takaki, et al.
    • Journal Title

      Molecular Immunology

      Volume: 57 Issue: 2 Pages: 100-110

    • DOI

      10.1016/j.molimm.2013.08.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA2013

    • Author(s)
      Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T.
    • Journal Title

      PLoS One

      Volume: 8(12)

    • NAID

      120005372326

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling2013

    • Author(s)
      Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110(49) Pages: 19908-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model2013

    • Author(s)
      Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.
    • Journal Title

      J Immunol

      Volume: 191(9) Pages: 4740-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses2013

    • Author(s)
      Oshiumi H, Miyashita M, Matsumoto M, Seya T.
    • Journal Title

      PLoS Pathog

      Volume: 9(8)

    • NAID

      120005326762

    • Related Report
      2013 Final Research Report
  • [Journal Article] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion2013

    • Author(s)
      Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
    • Journal Title

      J Virol

      Volume: 87(19) Pages: 10900-3

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells2013

    • Author(s)
      Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K.
    • Journal Title

      J Virol

      Volume: 87 Pages: 8169-78

    • Related Report
      2013 Final Research Report
  • [Journal Article] Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA2013

    • Author(s)
      Tatematsu M, Nishikawa F, Seya T, Matsumoto M.
    • Journal Title

      Nat Commun

      Volume: 4 Pages: 1833-1833

    • Related Report
      2013 Final Research Report
  • [Journal Article] Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer2013

    • Author(s)
      Seya T, Azuma M, Matsumoto M.
    • Journal Title

      Expert Opin Ther Targets

      Volume: 17(5) Pages: 533-44

    • Related Report
      2013 Final Research Report
  • [Journal Article] Multi-step regulation of interferon induction by hepatitis C virus2013

    • Author(s)
      Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
    • Journal Title

      Arch Immunol Ther Exp (Warsz)

      Volume: 61(2) Pages: 127-38

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cleaved/associated TLR3 represents the primary form of the signaling receptor2013

    • Author(s)
      Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T, Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
    • Journal Title

      J Immunol

      Volume: 190(2) Pages: 764-73

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.2013

    • Author(s)
      Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 110(49) Issue: 49 Pages: 19908-19913

    • DOI

      10.1073/pnas.1222811110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.2013

    • Author(s)
      Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.
    • Journal Title

      J Immunol.

      Volume: 191(9) Pages: 4740-4747

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.2013

    • Author(s)
      Oshiumi H, Miyashita M, Matsumoto M, Seya T.
    • Journal Title

      PLoS Pathog.

      Volume: 9(8) Issue: 8 Pages: e1003533-e1003533

    • DOI

      10.1371/journal.ppat.1003533

    • NAID

      120005326762

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.2013

    • Author(s)
      Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
    • Journal Title

      J Virol.

      Volume: 87(19) Issue: 19 Pages: 10900-10903

    • DOI

      10.1128/jvi.01427-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C Virus Infection Induces Inflammatory Cytokines and Chemokines Mediated by the Cross Talk between Hepatocytes and Stellate Cells.2013

    • Author(s)
      Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K.
    • Journal Title

      J. Viol

      Volume: 87 Issue: 14 Pages: 8169-8178

    • DOI

      10.1128/jvi.00974-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA2013

    • Author(s)
      Tatematsu, M., F. Nishikawe, T. Seya, M. Matsumoto
    • Journal Title

      Nat Commun.

      Volume: 4 Issue: 1 Pages: 1-833

    • DOI

      10.1038/ncomms2857

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer.2013

    • Author(s)
      Seya T, Azuma M, Matsumoto M.
    • Journal Title

      Expert Opin Ther Targets.

      Volume: 17(5) Issue: 5 Pages: 533-544

    • DOI

      10.1517/14728222.2013.765407

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multi-step regulation of interferon induction by hepatitis C virus.2013

    • Author(s)
      Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
    • Journal Title

      Arch Immunol Ther Exp (Warsz)

      Volume: 61(2) Issue: 2 Pages: 127-138

    • DOI

      10.1007/s00005-012-0214-x

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cleaved/associated TLR3 represents the primary form of the signaling receptor.2013

    • Author(s)
      Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T,Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
    • Journal Title

      J Immunol.

      Volume: 190(2) Issue: 2 Pages: 764-773

    • DOI

      10.4049/jimmunol.1202173

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structures and interface mapping of the Toll/Interleukin-1 receptor-domain-containing adaptor molecules involved in interferon signaling.2013

    • Author(s)
      Enokizono, Y., H. Kumeta, K. Funami, M. Horiuchi, J. Sarmiento, K. Yamashita, D. Standley, T. Seya, M. Matsumoto, F. Inagaki
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Riplet ubiquitin ligase plays a pivotal role in TRIM25-mediated RIG-I activation and is targeted by Hepatitis C Virus.2013

    • Author(s)
      Oshiumi, H., M. Miyashita, M. Matsumoto, and T. Seya
    • Journal Title

      PLoS Pathog.

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 3 recognizes single-stranded RNA with incomplete stem structures.2013

    • Author(s)
      Tatematsu, M., F. Nishikawa, T. Seya, M. Matsumoto.
    • Journal Title

      Nat Commun.

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012

    • Author(s)
      Shime H, M. Matsumoto, H. Oshiumi, S. Tanaka, A. Nakane, Y. Iwakura, H. Tahara, N. Inoue, and T. Seya.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Pages: 2066-2071

    • Related Report
      2013 Final Research Report
  • [Journal Article] Toll-like receptor 3-mediated antivirus response is important for protection against poliovirus infection in poliovirus receptor transgenic mice2012

    • Author(s)
      Abe, Y., K. Fujii, N. Nagata, O. Takeuchi, S. Akira, H. Oshiumi, M. Matsumoto, T. Seya, and S. Koike.
    • Journal Title

      J. Virol

      Volume: 86 Pages: 185-194

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dendritic cells from oral cavity induce Foxp3+ regulatory T cells upon antigen stimulation2012

    • Author(s)
      Yamazaki, S., A. Maruyama, K. Okada, M. Matsumoto, A. Morita, and T. Seya.
    • Journal Title

      PLoS ONE

      Volume: 7

    • NAID

      120005208896

    • Related Report
      2013 Final Research Report
  • [Journal Article] TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis.2012

    • Author(s)
      Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M.
    • Journal Title

      Oncoimmunol.

      Volume: 1 Issue: 6 Pages: 917-923

    • DOI

      10.4161/onci.21244

    • NAID

      120005228664

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] TAMable tumor-associated macrophages in response to innate RNA sensing.2012

    • Author(s)
      Seya T, Shime H, Matsumoto M.
    • Journal Title

      Oncoimmunol.

      Volume: 1 Issue: 6 Pages: 1000-1001

    • DOI

      10.4161/onci.19894

    • NAID

      120005228653

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I2012

    • Author(s)
      Oshiumi, H., M.Matsumoto, T.Seya
    • Journal Title

      J.Biochem.

      Volume: 151 Issue: 1 Pages: 5-11

    • DOI

      10.1093/jb/mvr111

    • NAID

      10031166037

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dendritic cells from oral cavity induce Foxp3^+ regulatory T cells upon antigen stimulation2012

    • Author(s)
      Yamazaki S #, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T(#Corresponding author)
    • Journal Title

      PLosOne

      Volume: 7 Issue: 12 Pages: 1-9

    • DOI

      10.1371/journal.pone.0051665

    • NAID

      120005208896

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012

    • Author(s)
      H.Shime
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 6 Pages: 2066-2071

    • DOI

      10.1073/pnas.1113099109

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Toll-like receptor 3-mediayed antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice2012

    • Author(s)
      Abe, Y., K.Fujii, N.Nagata, O.Takeuchi, S.Akira, H.Oshiumi, M.Matsumoto, T.Seya, S.Koike
    • Journal Title

      J.Virol

      Volume: 86 Issue: 1 Pages: 185-194

    • DOI

      10.1128/jvi.05245-11

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cross-presentation and antitumor CTL induced by soluble Ag + polyI:C largely depend on the TICAM-1 pathway in mouse CD11c+/CD8a+ dendritic cells.2012

    • Author(s)
      Azuma M., T. Ebihara, H. Oshiumi, M. Matsumoto, and T. Seya.
    • Journal Title

      OncoImmunol.

      Volume: 1 Issue: 5 Pages: 581-592

    • DOI

      10.4161/onci.19893

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro models for the analysis of HCV life cycle2011

    • Author(s)
      Aly HH, Shimotohno K, Hijikata M, Seya T
    • Journal Title

      Microbiol Immunol

      Volume: 56 Issue: 1 Pages: 1-9

    • DOI

      10.1111/j.1348-0421.2011.00403.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011

    • Author(s)
      Hazeki, K., Kametani, Y., et al, (11名中7番目)
    • Journal Title

      PLoS One.

      Volume: 6 Issue: 10 Pages: e26836-e26836

    • DOI

      10.1371/journal.pone.0026836

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Book] Oligomerization in Health and Diseases.2013

    • Author(s)
      Matsumoto, M., K. Funami, H. Oshiumi, and T. Seya
    • Publisher
      Academic Press, ELSEVIER INC.
    • Related Report
      2012 Research-status Report
  • [Remarks] HP

    • URL

      http://www.hucc.hokudai.ac.jp/~e20536/

    • Related Report
      2013 Final Research Report
  • [Remarks] 免疫学分野のホームページ

    • URL

      http://www.hucc.hokudai.ac.jp/~e20536/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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