An alternative interferon inducing pathway predicted through phylogenetic analyses
| Project/Area Number |
24659214
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SEYA Tsukasa 北海道大学, 医学(系)研究科(研究院), 教授 (10301805)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自然免疫 / パターン認識レセプター / インターフェロン |
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| Research Abstract |
Two membrane proteins having N-terminal extracellular domain Ig (immunoglobulin domain) and C-terminal Toll-IL-1 homology domain (TIR) were identified from the zebrafish database. We called these proteins Ig-TIR. We have cloned the cDNAs of these proteins and their functional properties were determined with overexpression and siRNA analysis using rainbow trout cell lines. We could not detect any activity affecting NF-kB activation, IFN induction or cytokine assays. We suppose that the Ig-TIR proteins have functions other than the known TLR proteins that sense microbial pattern molecules.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Cleaved/associated TLR3 represents the primary form of the signaling receptor2013
Author(s)
Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T, Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
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Journal Title
J Immunol
Volume: 190(2)
Pages: 764-73
Related Report
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[Journal Article] Cleaved/associated TLR3 represents the primary form of the signaling receptor.2013
Author(s)
Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T,Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
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Journal Title
J Immunol.
Volume: 190(2)
Issue: 2
Pages: 764-773
DOI
Related Report
Peer Reviewed
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[Journal Article] Structures and interface mapping of the Toll/Interleukin-1 receptor-domain-containing adaptor molecules involved in interferon signaling.2013
Author(s)
Enokizono, Y., H. Kumeta, K. Funami, M. Horiuchi, J. Sarmiento, K. Yamashita, D. Standley, T. Seya, M. Matsumoto, F. Inagaki
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Journal Title
Proc Natl Acad Sci USA
Volume: 印刷中
Related Report
Peer Reviewed
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