An alternative interferon inducing pathway predicted through phylogenetic analyses

• Project/Area Number: 24659214
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Hokkaido University
• Principal Investigator: SEYA Tsukasa 北海道大学, 医学(系)研究科(研究院), 教授 (10301805)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 自然免疫 / パターン認識レセプター / インターフェロン

Research Abstract

Two membrane proteins having N-terminal extracellular domain Ig (immunoglobulin domain) and C-terminal Toll-IL-1 homology domain (TIR) were identified from the zebrafish database. We called these proteins Ig-TIR. We have cloned the cDNAs of these proteins and their functional properties were determined with overexpression and siRNA analysis using rainbow trout cell lines. We could not detect any activity affecting NF-kB activation, IFN induction or cytokine assays. We suppose that the Ig-TIR proteins have functions other than the known TLR proteins that sense microbial pattern molecules.

Research Products

• [Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection (2014)
  • Author(s): Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T.
  • Journal Title: J Immunol Volume: (Epub ahead of print)
• [Journal Article] Beyond dsRNA : Toll-like receptor 3 signalling in RNA-induced immune responses (2014)
  • Author(s): Tatematsu M, Seya T, Matsumoto M.
  • Journal Title: Biochem J Volume: 458(2) Pages: 195-201
• [Journal Article] MAVS-dependent IRF3/7 bypass of interferonβ-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells (2014)
  • Author(s): Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T.
  • Journal Title: Mol Immunol Volume: 57(2) Pages: 100-10
• [Journal Article] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic : polycytidylic acid treatment in mouse tumor models (2014)
  • Author(s): Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T.
  • Journal Title: J Innate Immun Volume: 6 Pages: 293-305
• [Journal Article] Assessment of the Toll-like receptor 3 pathway in endosomal signaling (2014)
  • Author(s): Matsumoto M, Funami K, Tatematsu M, Azuma M, Seya T.
  • Journal Title: Methods Enzymol Volume: 535 Pages: 149-65
• [Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepetocytes and bendritic Cells in Response to Hepatitis C Virus Infection. (2014)
  • Author(s): Masaaki Okamoto, et al.
  • Journal Title: Journal of immunology Volume: 192 Issue: 6 Pages: 2770-7
  • DOI: 10.4049/jimmunol.1301459
  • Peer Reviewed
• [Journal Article] Beyond double-stranded RNA : TLR3 signaling in RNA-induced immune responses (2014)
  • Author(s): Tatematsu, M., T. Seya, M. Matsumoto
  • Journal Title: Biochem. J Volume: 458 Issue: 2 Pages: 195-201
  • DOI: 10.1042/bj20131492
  • Peer Reviewed
• [Journal Article] MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Ta mouse bone marrow-derived dendritic cells. (2014)
  • Author(s): Hiromi Takaki, et al.
  • Journal Title: Molecular Immunology Volume: 57 Issue: 2 Pages: 100-110
  • DOI: 10.1016/j.molimm.2013.08.007
  • Peer Reviewed
• [Journal Article] Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA (2013)
  • Author(s): Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T.
  • Journal Title: PLoS One Volume: 8(12)
  • NAID: 120005372326
• [Journal Article] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling (2013)
  • Author(s): Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110(49) Pages: 19908-13
• [Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model (2013)
  • Author(s): Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.
  • Journal Title: J Immunol Volume: 191(9) Pages: 4740-7
• [Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses (2013)
  • Author(s): Oshiumi H, Miyashita M, Matsumoto M, Seya T.
  • Journal Title: PLoS Pathog Volume: 9(8)
  • NAID: 120005326762
• [Journal Article] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion (2013)
  • Author(s): Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
  • Journal Title: J Virol Volume: 87(19) Pages: 10900-3
• [Journal Article] Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells (2013)
  • Author(s): Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K.
  • Journal Title: J Virol Volume: 87 Pages: 8169-78
• [Journal Article] Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA (2013)
  • Author(s): Tatematsu M, Nishikawa F, Seya T, Matsumoto M.
  • Journal Title: Nat Commun Volume: 4 Pages: 1833-1833
• [Journal Article] Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer (2013)
  • Author(s): Seya T, Azuma M, Matsumoto M.
  • Journal Title: Expert Opin Ther Targets Volume: 17(5) Pages: 533-44
• [Journal Article] Multi-step regulation of interferon induction by hepatitis C virus (2013)
  • Author(s): Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
  • Journal Title: Arch Immunol Ther Exp (Warsz) Volume: 61(2) Pages: 127-38
• [Journal Article] Cleaved/associated TLR3 represents the primary form of the signaling receptor (2013)
  • Author(s): Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T, Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
  • Journal Title: J Immunol Volume: 190(2) Pages: 764-73
• [Journal Article] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. (2013)
  • Author(s): Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 110(49) Issue: 49 Pages: 19908-19913
  • DOI: 10.1073/pnas.1222811110
  • Peer Reviewed
• [Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model. (2013)
  • Author(s): Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.
  • Journal Title: J Immunol. Volume: 191(9) Pages: 4740-4747
  • Peer Reviewed
• [Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses. (2013)
  • Author(s): Oshiumi H, Miyashita M, Matsumoto M, Seya T.
  • Journal Title: PLoS Pathog. Volume: 9(8) Issue: 8 Pages: e1003533-e1003533
  • DOI: 10.1371/journal.ppat.1003533
  • NAID: 120005326762
  • Peer Reviewed
• [Journal Article] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion. (2013)
  • Author(s): Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
  • Journal Title: J Virol. Volume: 87(19) Issue: 19 Pages: 10900-10903
  • DOI: 10.1128/jvi.01427-13
  • Peer Reviewed
• [Journal Article] Hepatitis C Virus Infection Induces Inflammatory Cytokines and Chemokines Mediated by the Cross Talk between Hepatocytes and Stellate Cells. (2013)
  • Author(s): Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K.
  • Journal Title: J. Viol Volume: 87 Issue: 14 Pages: 8169-8178
  • DOI: 10.1128/jvi.00974-13
  • Peer Reviewed
• [Journal Article] Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA (2013)
  • Author(s): Tatematsu, M., F. Nishikawe, T. Seya, M. Matsumoto
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 1-833
  • DOI: 10.1038/ncomms2857
  • Peer Reviewed
• [Journal Article] Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer. (2013)
  • Author(s): Seya T, Azuma M, Matsumoto M.
  • Journal Title: Expert Opin Ther Targets. Volume: 17(5) Issue: 5 Pages: 533-544
  • DOI: 10.1517/14728222.2013.765407
  • Peer Reviewed
• [Journal Article] Multi-step regulation of interferon induction by hepatitis C virus. (2013)
  • Author(s): Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
  • Journal Title: Arch Immunol Ther Exp (Warsz) Volume: 61(2) Issue: 2 Pages: 127-138
  • DOI: 10.1007/s00005-012-0214-x
  • Peer Reviewed
• [Journal Article] Cleaved/associated TLR3 represents the primary form of the signaling receptor. (2013)
  • Author(s): Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T,Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
  • Journal Title: J Immunol. Volume: 190(2) Issue: 2 Pages: 764-773
  • DOI: 10.4049/jimmunol.1202173
  • Peer Reviewed
• [Journal Article] Structures and interface mapping of the Toll/Interleukin-1 receptor-domain-containing adaptor molecules involved in interferon signaling. (2013)
  • Author(s): Enokizono, Y., H. Kumeta, K. Funami, M. Horiuchi, J. Sarmiento, K. Yamashita, D. Standley, T. Seya, M. Matsumoto, F. Inagaki
  • Journal Title: Proc Natl Acad Sci USA Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Riplet ubiquitin ligase plays a pivotal role in TRIM25-mediated RIG-I activation and is targeted by Hepatitis C Virus. (2013)
  • Author(s): Oshiumi, H., M. Miyashita, M. Matsumoto, and T. Seya
  • Journal Title: PLoS Pathog. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Toll-like receptor 3 recognizes single-stranded RNA with incomplete stem structures. (2013)
  • Author(s): Tatematsu, M., F. Nishikawa, T. Seya, M. Matsumoto.
  • Journal Title: Nat Commun. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors (2012)
  • Author(s): Shime H, M. Matsumoto, H. Oshiumi, S. Tanaka, A. Nakane, Y. Iwakura, H. Tahara, N. Inoue, and T. Seya.
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 2066-2071
• [Journal Article] Toll-like receptor 3-mediated antivirus response is important for protection against poliovirus infection in poliovirus receptor transgenic mice (2012)
  • Author(s): Abe, Y., K. Fujii, N. Nagata, O. Takeuchi, S. Akira, H. Oshiumi, M. Matsumoto, T. Seya, and S. Koike.
  • Journal Title: J. Virol Volume: 86 Pages: 185-194
• [Journal Article] Dendritic cells from oral cavity induce Foxp3+ regulatory T cells upon antigen stimulation (2012)
  • Author(s): Yamazaki, S., A. Maruyama, K. Okada, M. Matsumoto, A. Morita, and T. Seya.
  • Journal Title: PLoS ONE Volume: 7
  • NAID: 120005208896
• [Journal Article] TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis. (2012)
  • Author(s): Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M.
  • Journal Title: Oncoimmunol. Volume: 1 Issue: 6 Pages: 917-923
  • DOI: 10.4161/onci.21244
  • NAID: 120005228664
  • Peer Reviewed
• [Journal Article] TAMable tumor-associated macrophages in response to innate RNA sensing. (2012)
  • Author(s): Seya T, Shime H, Matsumoto M.
  • Journal Title: Oncoimmunol. Volume: 1 Issue: 6 Pages: 1000-1001
  • DOI: 10.4161/onci.19894
  • NAID: 120005228653
  • Peer Reviewed
• [Journal Article] Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I (2012)
  • Author(s): Oshiumi, H., M.Matsumoto, T.Seya
  • Journal Title: J.Biochem. Volume: 151 Issue: 1 Pages: 5-11
  • DOI: 10.1093/jb/mvr111
  • NAID: 10031166037
  • Peer Reviewed
• [Journal Article] Dendritic cells from oral cavity induce Foxp3^+ regulatory T cells upon antigen stimulation (2012)
  • Author(s): Yamazaki S #, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T(#Corresponding author)
  • Journal Title: PLosOne Volume: 7 Issue: 12 Pages: 1-9
  • DOI: 10.1371/journal.pone.0051665
  • NAID: 120005208896
  • Peer Reviewed
• [Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors (2012)
  • Author(s): H.Shime
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Issue: 6 Pages: 2066-2071
  • DOI: 10.1073/pnas.1113099109
  • Peer Reviewed
• [Journal Article] The Toll-like receptor 3-mediayed antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice (2012)
  • Author(s): Abe, Y., K.Fujii, N.Nagata, O.Takeuchi, S.Akira, H.Oshiumi, M.Matsumoto, T.Seya, S.Koike
  • Journal Title: J.Virol Volume: 86 Issue: 1 Pages: 185-194
  • DOI: 10.1128/jvi.05245-11
  • Peer Reviewed
• [Journal Article] Cross-presentation and antitumor CTL induced by soluble Ag + polyI:C largely depend on the TICAM-1 pathway in mouse CD11c+/CD8a+ dendritic cells. (2012)
  • Author(s): Azuma M., T. Ebihara, H. Oshiumi, M. Matsumoto, and T. Seya.
  • Journal Title: OncoImmunol. Volume: 1 Issue: 5 Pages: 581-592
  • DOI: 10.4161/onci.19893
  • Peer Reviewed
• [Journal Article] In vitro models for the analysis of HCV life cycle (2011)
  • Author(s): Aly HH, Shimotohno K, Hijikata M, Seya T
  • Journal Title: Microbiol Immunol Volume: 56 Issue: 1 Pages: 1-9
  • DOI: 10.1111/j.1348-0421.2011.00403.x
  • Peer Reviewed
• [Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages (2011)
  • Author(s): Hazeki, K., Kametani, Y., et al, (11名中7番目)
  • Journal Title: PLoS One. Volume: 6 Issue: 10 Pages: e26836-e26836
  • DOI: 10.1371/journal.pone.0026836
  • Peer Reviewed
• [Book] Oligomerization in Health and Diseases. (2013)
  • Author(s): Matsumoto, M., K. Funami, H. Oshiumi, and T. Seya
  • Publisher: Academic Press, ELSEVIER INC.
• [Remarks] HP
  • URL: http://www.hucc.hokudai.ac.jp/~e20536/
• [Remarks] 免疫学分野のホームページ
  • URL: http://www.hucc.hokudai.ac.jp/~e20536/