Elucidation of Regulatory Mechanism of B1 Cells by Human IgG Natural Antibodies
Project/Area Number |
24659215
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 自己抗体 / 自然免疫 / 末梢血Bリンパ球 / 制御受容体 / γグロブリン製剤 / 末梢血Bリンバ球 / 自己免疫 / 免疫制御能 / B1細胞 / IgG |
Research Abstract |
We defined human peripheral blood CD20+CD27+CD43+CD70- B cells as "putative (puB1) B1 cells", and characterized them in terms of expression profiles for B cell inhibitory receptors including several isoforms of ILT/LILR and Ig production. We found a grossly similar profiles of the inhibitory receptors on puB1 cells and memory B cells, but distinctive receptor expression and Ig secretion profiles between the puB1 subset and CD43high plasmablasts.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy2013
Author(s)
Stroo I,Tammarro A,Rampanelli E,Blank F,Butter L,Claessen N,Takai T,Colonna M,Leemans J,Florquin S,Dessing MC.
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Journal Title
PLOS ONE
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013
Author(s)
Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
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Journal Title
mice.
Volume: 43
Issue: 3
Pages: 770-778
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy.2013
Author(s)
Stroo I, Tammarro A, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing MC.
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Journal Title
PLOS ONE
Volume: 8(12)
Issue: 12
Pages: e82498-e82498
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence2012
Author(s)
Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.
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Journal Title
J Immunol
Volume: 189
Issue: 12
Pages: 5903-5911
DOI
Related Report
Peer Reviewed
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