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Elucidation of Regulatory Mechanism of B1 Cells by Human IgG Natural Antibodies

Research Project

Project/Area Number 24659215
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionTohoku University

Principal Investigator

TAKAI TOSHIYUKI  東北大学, 加齢医学研究所, 教授 (20187917)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords自己抗体 / 自然免疫 / 末梢血Bリンパ球 / 制御受容体 / γグロブリン製剤 / 末梢血Bリンバ球 / 自己免疫 / 免疫制御能 / B1細胞 / IgG
Research Abstract

We defined human peripheral blood CD20+CD27+CD43+CD70- B cells as "putative (puB1) B1 cells", and characterized them in terms of expression profiles for B cell inhibitory receptors including several isoforms of ILT/LILR and Ig production. We found a grossly similar profiles of the inhibitory receptors on puB1 cells and memory B cells, but distinctive receptor expression and Ig secretion profiles between the puB1 subset and CD43high plasmablasts.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (5 results) (of which Invited: 1 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy2013

    • Author(s)
      Stroo I,Tammarro A,Rampanelli E,Blank F,Butter L,Claessen N,Takai T,Colonna M,Leemans J,Florquin S,Dessing MC.
    • Journal Title

      PLOS ONE

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes.2013

    • Author(s)
      Montalvo V, Quigley L, Vistica BP, Boelte KC, Nugent LF, Takai T, McVicar DW, Gery I.
    • Journal Title

      Immunology

      Volume: Dec;140(4) Issue: 4 Pages: 475-482

    • DOI

      10.1111/imm.12158

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection.2013

    • Author(s)
      Makoto Matsumoto, Yuki Sasaki, Koubun Yasuda, Toshiyuki Takai, Masamichi Muramatsu, Tomohiro Yoshimoto, Kenji Nakanishi.
    • Journal Title

      Infection and Immunity

      Volume: Vol.81、No.7 Issue: 7 Pages: 2518-2527

    • DOI

      10.1128/iai.00285-13

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.2013

    • Author(s)
      Kuroki Kら
    • Journal Title

      Hum Immunol.

      Volume: 74 Issue: 4 Pages: 433-438

    • DOI

      10.1016/j.humimm.2012.11.060

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013

    • Author(s)
      Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
    • Journal Title

      mice.

      Volume: 43 Issue: 3 Pages: 770-778

    • DOI

      10.1002/eji.201243057

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy.2013

    • Author(s)
      Stroo I, Tammarro A, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing MC.
    • Journal Title

      PLOS ONE

      Volume: 8(12) Issue: 12 Pages: e82498-e82498

    • DOI

      10.1371/journal.pone.0082498

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravenous immunoglobulin suppresses IL-10 production by activated B cells in vitro2012

    • Author(s)
      Tanaka J
    • Journal Title

      Open J. Immunol.

      Volume: vol. 2 Issue: 04 Pages: 149-160

    • DOI

      10.4236/oji.2012.24019

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence2012

    • Author(s)
      Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.
    • Journal Title

      J Immunol

      Volume: 189 Issue: 12 Pages: 5903

    • DOI

      10.4049/jimmunol.1201940

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of plasmacytoid dendritic cell responses by PIR-B.2012

    • Author(s)
      MitsuhashiY,NakamuraA,EndoS,TakedaK,Yabe-WadaT,NukiwaT,TakaiT(correspondenceauthor)
    • Journal Title

      Blood

      Volume: 120 Issue: 16 Pages: 3256-3259

    • DOI

      10.1182/blood-2012-03-419093

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deletion of cognate CD8 T-cells by immature dendritic cells: a novel role for perforin, Granzyme A, TREM-1 and TLR72012

    • Author(s)
      Zangi L
    • Journal Title

      Blood

      Volume: 120 Issue: 8 Pages: 1647-57

    • DOI

      10.1182/blood-2012-02-410803

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.2012

    • Author(s)
      Wong WF, Tazawa R, (15名略)Nakata K, Takai T, Satake M.
    • Journal Title

      J Immunol.

      Volume: 188(11) Issue: 11 Pages: 5408-5420

    • DOI

      10.4049/jimmunol.1102991

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Negative regulation of autoantibody production by a B cell inhibitory receptor FcγRIIB2013

    • Author(s)
      Toshiyuki Takai,Yasuyoshi Kanari,Akiko Sugahara-Tobinai
    • Organizer
      NIH-Tohoku University-JSPS Symposium
    • Place of Presentation
      Gonryo Hall,Sendai
    • Related Report
      2013 Final Research Report
  • [Presentation] Nogo positively regulates TLR signal pathway and inflammatory gene expression in macrophages2013

    • Author(s)
      Kimura T,Inui M,Takai T.
    • Organizer
      Frontiers in Immunology and Inflammation : From Molecules to Disease
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of TLR signaling by a reticulon family protein Nogo in macrophages2012

    • Author(s)
      Kimura T,Inui M,Takai T.
    • Organizer
      The Annual Meeting of the japanese Society for Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2012-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor,FcgRIIB,Centennial of Hashimoto Disease Symposium2012

    • Author(s)
      Toshiyuki Takai
    • Organizer
      International Symposium II : Autoimmune Diseases-Etiology and Therapeutics
    • Place of Presentation
      ACROS Fukuoka
    • Year and Date
      2012-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor, FcγRIIB

    • Author(s)
      Toshiyuki Takai
    • Organizer
      Centennial of Hashimoto Disease Symposium
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 医学のあゆみ 自己免疫病とPirB(245)2013

    • Author(s)
      乾匡範,高井俊行
    • Related Report
      2013 Final Research Report
  • [Book] Clin Calcium 免疫グロプリン様受容体による破骨細胞の分化制御(22(11))2012

    • Author(s)
      乾匡範,高井俊行
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www2.idac.tohoku.ac.jp/dep/expimmu/

    • Related Report
      2013 Final Research Report
  • [Remarks] 遺伝子導入研究分野ホームページ

    • Related Report
      2013 Annual Research Report
  • [Remarks] 遺伝子導入研究分野ホームページ

    • URL

      http://www2.idac.tohoku.ac.jp/dep/expimmu/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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