Elucidation of Regulatory Mechanism of B1 Cells by Human IgG Natural Antibodies

• Project/Area Number: 24659215
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Tohoku University
• Principal Investigator: TAKAI TOSHIYUKI 東北大学, 加齢医学研究所, 教授 (20187917)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 自己抗体 / 自然免疫 / 末梢血Bリンパ球 / 制御受容体 / γグロブリン製剤 / 末梢血Bリンバ球 / 自己免疫 / 免疫制御能 / B1細胞 / IgG

Research Abstract

We defined human peripheral blood CD20+CD27+CD43+CD70- B cells as "putative (puB1) B1 cells", and characterized them in terms of expression profiles for B cell inhibitory receptors including several isoforms of ILT/LILR and Ig production. We found a grossly similar profiles of the inhibitory receptors on puB1 cells and memory B cells, but distinctive receptor expression and Ig secretion profiles between the puB1 subset and CD43high plasmablasts.

Research Products

• [Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy (2013)
  • Author(s): Stroo I,Tammarro A,Rampanelli E,Blank F,Butter L,Claessen N,Takai T,Colonna M,Leemans J,Florquin S,Dessing MC.
  • Journal Title: PLOS ONE Volume: (in press)
  • Peer Reviewed
• [Journal Article] Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes (2013)
  • Author(s): Montalvo V, Quigley L, Vistica BP, Boelte KC, Nugent LF, Takai T, McVicar DW, Gery I.
  • Journal Title: lmmunology Volume: Dec;140(4) Pages: 475-482
  • DOI: 10.1111/imm.12158
  • Peer Reviewed
• [Journal Article] IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensis in a Primary Infection (2013)
  • Author(s): Makoto Matsumoto, Yuki Sasaki, Koubun Yasuda, Toshiyuki Takai, Masamichi Muramatsu, Tomohiro Yoshimoto, Kenji Nakanishi.
  • Journal Title: lnfect. lmmun Volume: Vol.81、No.7 Pages: 2518-2527
  • DOI: 10.1128/iai.00285-13
  • Peer Reviewed
• [Journal Article] The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis (2013)
  • Author(s): Kuroki Kら
  • Journal Title: Hum lmmunol Volume: 74 Pages: 433-438
  • DOI: 10.1016/j.humimm.2012.11.060
  • NAID: 120005297913
  • Peer Reviewed
• [Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-de ficient C57BL/6 mice. (2013)
  • Author(s): Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
  • Journal Title: Eur J Immunol. Volume: 43 Pages: 770-778
  • DOI: 10.1002/eji.201243057
  • Peer Reviewed
• [Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy. (2013)
  • Author(s): Stroo I, Tammarro A, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing MC.
  • Journal Title: PLOS ONE Volume: 8(12)
  • DOI: 10.1371/journal.pone.0082498
  • Peer Reviewed
• [Journal Article] Intravenous immunoglobulin suppresses IL-10 production by activated B cells in vitro (2012)
  • Author(s): Tanaka J
  • Journal Title: Open J. lmmunol Volume: vol. 2 Pages: 149-160
  • DOI: 10.4236/oji.2012.24019
  • Peer Reviewed
• [Journal Article] Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence (2012)
  • Author(s): Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.
  • Journal Title: J. lmmunol Volume: 189 Pages: 5903-11
  • DOI: 10.4049/jimmunol.1201940
  • Peer Reviewed
• [Journal Article] Regulation of plasmacytoid dendritic cell responses by PIR-B (2012)
  • Author(s): MitsuhashiY,NakamuraA,EndoS,TakedaK,Yabe-WadaT,NukiwaT,TakaiT(correspondenceauthor)
  • Journal Title: Blood Volume: 120 Pages: 3256-3259
  • DOI: 10.1182/blood-2012-03-419093
  • Peer Reviewed
• [Journal Article] Deletion of cognate CD8 T-cells by immature dendritic cells : a novel role for perforin,Granzyme A,TREM-1 and TLR7 (2012)
  • Author(s): Zangi L
  • Journal Title: Blood Volume: 120 Pages: 1647-57
  • DOI: 10.1182/blood-2012-02-410803
  • Peer Reviewed
• [Journal Article] Runx1-deficiency in CD4^+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells (2012)
  • Author(s): Wong WF, Tazawa R, （15名略）Nakata K, Takai T, Satake M.
  • Journal Title: J. Immunol Volume: 188(11) Pages: 5408-20
  • DOI: 10.4049/jimmunol.1102991
  • Peer Reviewed
• [Presentation] Negative regulation of autoantibody production by a B cell inhibitory receptor FcγRIIB (2013)
  • Author(s): Toshiyuki Takai,Yasuyoshi Kanari,Akiko Sugahara-Tobinai
  • Organizer: NIH-Tohoku University-JSPS Symposium
  • Place of Presentation: Gonryo Hall,Sendai
• [Presentation] Nogo positively regulates TLR signal pathway and inflammatory gene expression in macrophages (2013)
  • Author(s): Kimura T,Inui M,Takai T.
  • Organizer: Frontiers in Immunology and Inflammation : From Molecules to Disease
  • Place of Presentation: Tokyo
• [Presentation] Regulation of TLR signaling by a reticulon family protein Nogo in macrophages (2012)
  • Author(s): Kimura T,Inui M,Takai T.
  • Organizer: The Annual Meeting of the japanese Society for Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2012-12-05
• [Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor,FcgRIIB,Centennial of Hashimoto Disease Symposium (2012)
  • Author(s): Toshiyuki Takai
  • Organizer: International Symposium II : Autoimmune Diseases-Etiology and Therapeutics
  • Place of Presentation: ACROS Fukuoka
  • Year and Date: 2012-12-03
• [Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor, FcγRIIB
  • Author(s): Toshiyuki Takai
  • Organizer: Centennial of Hashimoto Disease Symposium
  • Place of Presentation: Fukuoka
  • Invited
• [Book] 医学のあゆみ 自己免疫病とPirB(245) (2013)
  • Author(s): 乾匡範,高井俊行
• [Book] Clin Calcium 免疫グロプリン様受容体による破骨細胞の分化制御(22(11)) (2012)
  • Author(s): 乾匡範,高井俊行
• [Remarks]
  • URL: http://www2.idac.tohoku.ac.jp/dep/expimmu/
• [Remarks] 遺伝子導入研究分野ホームページ
• [Remarks] 遺伝子導入研究分野ホームページ
  • URL: http://www2.idac.tohoku.ac.jp/dep/expimmu/