| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the immunological function of mast cell subset using P2X7-specific antibody. We found that colonic mast cells spontaneously expressed high levels of P2X7, which played a critical role in the initiation and exacerbation of intestinal inflammation. In contrast, skin mast cells barely expressed P2X7, which was mediated by retinoic acid metabolism in skin fibroblast. We further found that disruption of the retinoic acid metabolism led to the development of skin inflammation.
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