Factors for the decision of mast cell subset function
Project/Area Number |
24659217
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | 独立行政法人医薬基盤研究所 |
Principal Investigator |
JUN Kunisawa 独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー (80376615)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | アレルギー・ぜんそく / 免疫学 / 細胞・組織 / マスト細胞 / 炎症 / アレルギー / 粘膜免疫 |
Outline of Final Research Achievements |
In this study, we analyzed the immunological function of mast cell subset using P2X7-specific antibody. We found that colonic mast cells spontaneously expressed high levels of P2X7, which played a critical role in the initiation and exacerbation of intestinal inflammation. In contrast, skin mast cells barely expressed P2X7, which was mediated by retinoic acid metabolism in skin fibroblast. We further found that disruption of the retinoic acid metabolism led to the development of skin inflammation.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] The enzyme cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.2014
Author(s)
Kurashima Y, Amiya T, Fjisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
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Journal Title
Immunity
Volume: 40
Issue: 4
Pages: 530-541
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice2013
Author(s)
J. Kunisawa, M. Gohda, E. Hashimoto, I. Ishikawa, M. Higuchi, Y. Suzuki, Y. Goto, C. Panea, I. I. Ivanov, R. Sumiya, L. Aayam, T. Wake, S. Tajiri, Y. Kurashima, S. Shikata、S. Akira, K. Takeda, H. Kiyono
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Journal Title
Nat Commun.
Volume: 10-1038
Issue: 1
Pages: 1038-1038
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors2012
Author(s)
Y. Kurashima, T. Amiya, T. Nochi, K. Fujisawa, T. Haraguchi, H. Iba, H. Tsutsui, S. Sato, S. Nakajima, H. Iijima, M. Kubo, J. Kunisawa, H. Kiyono
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Journal Title
Nat Commun.
Volume: 3-1034
Issue: 1
Pages: 1034-1034
DOI
Related Report
Peer Reviewed
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