New DC-mediated machinery to fine-tune excessive immune responses
| Project/Area Number |
24659219
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 血球貪食 / 免疫寛容 / DC / IL-10 / 過剰免疫応答 / 樹状細胞 / ウィルス感染 / CTL / 肝傷害 |
|---|
| Research Abstract |
Henophagocytpsis is conventionally viewed as an indicator of severe inflammation. We established a murine model for hemophagocytosis. Using this model, we newly found that DC-mediated hemophagocytosis is the machinery to fine-tune excessive immune responses and assure host survival under severe infectious and inflammatory conditions.
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Report
(2 results)
Research Products
(15 results)
