Analysis of function of misfolded proteins presented on MHC class II molecules.
| Project/Area Number |
24659223
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
ARASE Hisashi 大阪大学, 微生物病研究所, 教授 (10261900)
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| Project Period (FY) |
2012-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 抗原認識 / B細胞 / MHCクラスII / 自己免疫疾患 / T細胞 / 関節リウマチ / 自己抗体 / HLA-DR / MHCクラスI |
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| Research Abstract |
MHC class II molecules play an important role in immune response by presenting peptide antigens to T cells. However, we found that MHC class II molecules transport cellular misfolded proteins to the cell surface without processing to peptides. Therefore, we analyzed functions of misfolded proteins transported to the cell surface by MHC class II molecules in this study. We found that proteins presented on MHC class II molecules efficiently stimulate antigen specific B cells. Although MHC class II molecules have been thought to present peptide antigens to T cells, our findings indicate that MHC class II molecules can present protein antigens to B cells. Furthermore, when we analyzed autoantibodies from autoimmune patients, we found that proteins presented on MHC class II molecules are specifically recognized by autoantibodies. These findings suggested that misfolded proteins aberrantly presented on MHC class II molecules are a target autoimmune diseases.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα.2014
Author(s)
Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 111(24)
Issue: 24
Pages: 8877-8882
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages.2014
Author(s)
Haldar, M., Kohyama, M., So, A.Y., Kc, W., Wu, X., Briseno, C.G., Satpathy, A.T., Kretzer, N.M., Arase, H., Rajasekaran, N.S., Wang, L., Egawa, T., Igarashi, K., Baltimore, D., Murphy, T.L., and Murphy, K.M.
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Journal Title
Cell
Volume: 156
Issue: 6
Pages: 1223-1234
DOI
Related Report
Peer Reviewed
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[Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014
Author(s)
Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
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Journal Title
Proceedings of National Academy of Science USA
Volume: 111
Issue: 10
Pages: 3787-3792
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules.2013
Author(s)
Jiang, Y., Arase, N., Kohyama, M., Hirayasu, K., Suenaga, T., Jin, H., Matsumoto, M., Shida, K., L. Lanier, L., Saito, T. and Arase, H.
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Journal Title
Int. Immunol.
Volume: 25
Issue: 4
Pages: 235-246
DOI
Related Report
Peer Reviewed
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[Presentation] Transport of misfolded ER proteins to the cell surface by MHC class II molecules2012
Author(s)
Yan Jiang,Hui Jin,Masako Kohyama,Noriko Arase,Kouyuki Hirayasu,Tadahiro Suenaga,Maki Matsumoto,Kyoko Shida,Lewis L. Lanier,Takashi Saito,Ichiro Katayama and Hisashi Arase
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸国際会議場(神戸)
Year and Date
2012-12-06
Related Report
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[Presentation] Transport of misfolded ER proteins to the cell surface by MHC class II molecules
Author(s)
Jiang Y, Arase N, Kohyama M, Hirayasu K, Suenaga T, Jin H, Matsumoto M, Shida K, Lanier LL, Saito T, Arase H.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸国際会議場（兵庫県）
Related Report
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