Analysis of the pathogenesis of Alzheimer's disease by IL-33
| Project/Area Number |
24659226
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIZAKI Tomoyuki 兵庫医科大学, 医学部, 教授 (00221474)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | IL-33 / アルツハイマー病 / 学習・記憶 |
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| Outline of Final Research Achievements |
A recent report has revealed a gene polymorphism that is associated with reduced risk of Alzheimer's disease within the IL-33 gene region in addition to decreased IL-33 expression in the brains of patients with Alzheimer's disease. Furthermore, IL-33 has been reported to reduce the expression of beta-amyloid (Abeta40). Thus, it has been suggested that IL-33 may act as inhibitors against the development of Alzheimer's disease. However, the precise mechanism of reduced IL-33 expression and the physiological role for cognitive function of IL-33 in the brain remains unclear. In this study, we investigated the physiological role of IL-33 in cognitive function using IL-33 deficient mice. As a result, we revealed that IL-33 and its intracellular signaling factor is involved in learning and memory formation.
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Report
(3 results)
Research Products
(55 results)
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[Journal Article] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishii KJ, Yoshimoto T, Akira S, Nakanishi K.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 109
Pages: 3451-56
Related Report
Peer Reviewed
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[Journal Article] A critical role of IL-33 in experimental allergic rhinitis.2012
Author(s)
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T.
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Journal Title
J Allergy Clin Immunol
Volume: 130
Pages: 184-94
Related Report
Peer Reviewed
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[Journal Article] Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes.2012
Author(s)
Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara K.
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Journal Title
Allergol Int
Volume: 61
Pages: 563-72
NAID
Related Report
Peer Reviewed
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[Journal Article] IL-33.2012
Author(s)
松葉沙織, 善本知広.
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Journal Title
サイトカインのすべて.
Volume: 57 (Suppl. 21)
Pages: 208-17
Related Report
Peer Reviewed
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[Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice.2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishi KJ, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第77回日本インターフェロン・サイトカイン学会学術集会
Place of Presentation
神戸
Related Report
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[Presentation] Chitin induces lung eosinophilia dependently on IL-33.2012
Author(s)
Muto T, Yasuda K, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi-Yumikura S, Tsutsui H, Ishi K, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
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[Presentation] Contibution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice.2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi-Yumikura S, Tsutsui H, Ishi K, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
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