| Project/Area Number |
24659246
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical sociology
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAGAI Asuka 東海大学, 医学部, 助教 (40514550)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 早期喫煙暴露 / 喫煙 / COPD / IMT / vascular comorbidities / systemic effects / 禁煙 / ＣＯＰＤ / ＩＭＴ / 心血管イベント / 合併症 / 併存症 / ｓystemic effects / 頸動脈内膜中膜複合体肥厚度 / 動脈硬化 / 脳血管障害 |
|---|
| Research Abstract |
We hypothesized that COPD from early exposure to tobacco smoke may cause an increase of the intima media thickness (IMT) that correlates with the increase in the prevalence of smoke-related vascular comorbidities such as cardiovascular and cerebrovascular diseases. We divided potential subjects from the Erimo town clinic into three groups. A total of 152 subjects were enrolled into the study after informed consents were obtained. Groups with a history of COPD tended to have higher maximum values of IMT when compared with a group without COPD. Furthermore, Group 1 demonstrated highest value of IMT. In subjects with COPD, early smoke exposure promoted atherosclerotic changes, which may increase the likelihood of smoke-related vascular comorbidities such as cardiovascular and cerebrovascular diseases.
|
