| Project/Area Number |
24659255
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
YANAI KAZUHIKO 東北大学, 医学(系)研究科(研究院), 教授 (50192787)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Takeo 東北大学, 大学院医学系研究科, 助教 (70506633)
SHIBUYA Katsuhiko 東北大学, 大学院医学系研究科, 技術職員 (30596268)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子イメージング / マーモセット / 小動物用PET / 被ばく線量 / PET / 小動物イメージング / 神経変性疾患 / 炭素１１ / フッ素１８ / トランスレーショナルリサーチ / 薬理学 / 放射線 / 脳・神経・脳神経疾患 |
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| Research Abstract |
The marmoset animals are very useful for translational research. In order to keep marmosets in the PET facility and use the animals for small animal PET imaging, we investigated the regulations on animal breeding in the restricted areas of short half-life radioisotopes. We recognized that the animals administered with carbon-11 (half-life 20 min) and fluorine-18 (half-life 110 min) should be kept inside the PET centers for one week. In parallel, we performed molecular imaging studies on small animals. It is possible to estimate the radiation dosimetry in humans from distribution data obtained by small animal PET. The advantage of molecular imaging is reduction of used animals for translational research.
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