Generation of molecular imaging pharmacology using small primate mamosets

• Project/Area Number: 24659255
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Tohoku University
• Principal Investigator: YANAI KAZUHIKO 東北大学, 医学(系)研究科(研究院), 教授 (50192787)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Takeo 東北大学, 大学院医学系研究科, 助教 (70506633) ; SHIBUYA Katsuhiko 東北大学, 大学院医学系研究科, 技術職員 (30596268)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 分子イメージング / マーモセット / 小動物用PET / 被ばく線量 / PET / 小動物イメージング / 神経変性疾患 / 炭素１１ / フッ素１８ / トランスレーショナルリサーチ / 薬理学 / 放射線 / 脳・神経・脳神経疾患

Research Abstract

The marmoset animals are very useful for translational research. In order to keep marmosets in the PET facility and use the animals for small animal PET imaging, we investigated the regulations on animal breeding in the restricted areas of short half-life radioisotopes. We recognized that the animals administered with carbon-11 (half-life 20 min) and fluorine-18 (half-life 110 min) should be kept inside the PET centers for one week. In parallel, we performed molecular imaging studies on small animals. It is possible to estimate the radiation dosimetry in humans from distribution data obtained by small animal PET. The advantage of molecular imaging is reduction of used animals for translational research.

Research Products

• [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET (2014)
  • Author(s): Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
  • Journal Title: Brain Volume: (in press)
  • Peer Reviewed
• [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non Alzheimer's disease tauopathies (2014)
  • Author(s): Michelle T. Fodero-Tavoletti, Shozo Furumoto, Leanne Taylor, Catriona A McLean, Rachel S Mulligan, Ian Birchall, Ryuichi Harada, Colin L Masters, Kazuhiko Yanai, Yukitsuka Kudo, Christopher C Rowe, Nobuyuki Okamura, Victor L Villemagne
  • Journal Title: Alzheimers Res Ther Volume: 6 Pages: 11-11
  • DOI: 10.1186/alzrt240
  • Peer Reviewed
• [Journal Article] Mechanism of the histamine H(3) receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice. (2014)
  • Author(s): Mohsen A, Yoshikawa T, Miura Y, Nakamura T, Naganuma F, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K.
  • Journal Title: Neuropharmacology. Volume: 81 Pages: 188-194
  • DOI: 10.1016/j.neuropharm.2014.02.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging. (2014)
  • Author(s): Villemagne L. Victor, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Oliver Piguet, Svetlana Pejoska, Vincent Doré, Kazuhiko Yanai, Colin L. Masters, Yukitsuka Kudo, Christopher C. Rowe, Nobuyuki Okamura.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 41 Pages: 18-24
  • DOI: 10.1007/s00259-013-2681-7
  • Peer Reviewed / Open Access
• [Journal Article] Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line (2014)
  • Author(s): Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomistu Iida, Ryuichi Harada, Attayeb S. Mohsen, Yamato Miura and Kazuhiko Yanai.
  • Journal Title: J Neurochem. Volume: 129 Pages: 591-601
  • DOI: 10.1111/jnc.12665
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synthesis and preliminary evaluataion of 2-arylhydroxyquinoline derivatives for tau imaging. (2014)
  • Author(s): Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Yoichi Ishikawa, Hiroyuki Arai, Kazuhiko Yanai, Ren Iwata, Yhkitsuka Kudo
  • Journal Title: J Labelled Comp Radiopharm. Volume: 57 Pages: 18-24
  • DOI: 10.1002/jlcr.3133
  • Peer Reviewed
• [Journal Article] Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis (2014)
  • Author(s): Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
  • Journal Title: Jpn J Radiol. Volume: 32 Pages: 138-144
  • DOI: 10.1007/s11604-013-0276-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro (2014)
  • Author(s): Guo Y, Furukawa K, et al.
  • Journal Title: Exp Gerontol Volume: 50 Pages: 1-8
  • DOI: 10.1016/j.exger.2013.11.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT : comparison with [ 11C]PIB (2014)
  • Author(s): Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41(4) Pages: 745-54
  • Peer Reviewed
• [Journal Article] The expression and function of histamine H3 Receptor in Pancreatic 13-cells (2014)
  • Author(s): Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K.
  • Journal Title: Br. J. Pharmacol Volume: 171 (1) Pages: 171-85
  • Peer Reviewed
• [Journal Article] Use of a Benzimidazole Derivative BF-188 in Fluorescence Multispectral Imaging for Selective Visualization of Tau Protein Fibrils in the Alzheimer's Disease Brain (2014)
  • Author(s): Harada R, Okamura N, Furumoto S, Yoshikawa T, Arai H, Yanai K, Kudo Y.
  • Journal Title: Mol Imaging Biol Volume: 16(1) Pages: 19-27
  • Peer Reviewed
• [Journal Article] Roles played by histamine in strenuous or prolonged masseter muscle activity in mice (2013)
  • Author(s): Yoneda H, Niijima-Yaoita F, Tsuchiya M, Kumamoto H, Watanabe M, Ohtsu H, Yanai K, Tadano T, Sasaki K, Sugawara S, Endo Y.
  • Journal Title: Clin. Exp. Pharmacol. Physiol. Volume: 40 Pages: 848-55
  • DOI: 10.1111/1440-1681.12167
  • Peer Reviewed
• [Journal Article] Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Tago T, Y oshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Y amamoto T, Arai H, Iwata R, Y anai K, Kudo Y
  • Journal Title: J Nucl Med. Volume: 54 Pages: 1420-1427
  • DOI: 10.2967/jnumed.112.117341
  • Peer Reviewed
• [Journal Article] In-vitro and in-vivo characterization of 2-deoxy-2-[18F]fluoro-D-mannose as a tumor-imaging agent for positron emission tomography. (2013)
  • Author(s): Furumoto S, Shinbo R, Iwata R, Ishikawa Y, Ynai K, Yoshioka T, Fukuda H
  • Journal Title: J. Nucl. Med. Mol. Imag. Volume: 54 Pages: 1354-1361
  • DOI: 10.2967/jnumed.112.113571
  • Peer Reviewed
• [Journal Article] Histamine H receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers. (2013)
  • Author(s): Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K.
  • Journal Title: Psychopharmacology (Berl). Volume: 230 (2) Pages: 227-234
  • DOI: 10.1007/s00213-013-3146-1
  • Peer Reviewed
• [Journal Article] Effects of Preceding Stimulation on Brain Activation in Response to Colonic Distention in Humans (2013)
  • Author(s): Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
  • Journal Title: Psychosom Med Volume: 75(5) Pages: 453-62
  • Peer Reviewed
• [Journal Article] Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro (2013)
  • Author(s): Kaijun Niu, Hui Guo, Yinting Guo, Satoru Ebihara, Masanori Asada, Takashi Ohrui, Katsutoshi Furukawa, Masakazu Ichinose,Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai, Tatsuma Okazaki, and Ryoichi Nagatomi
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: (掲載確定) Pages: 1482-1492
  • DOI: 10.1093/gerona/glt041
  • Peer Reviewed
• [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans. (2013)
  • Author(s): Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
  • Journal Title: EJNMMI Res. Volume: 3 Pages: 32-32
  • DOI: 10.1186/2191-219x-3-32
  • Peer Reviewed
• [Journal Article] Molecular mechanism of histamine clearance by primary human astrocytes. (2013)
  • Author(s): Yoshikawa T, Naganuma F, Iida T, Nakamura T, Harada R, Mohsen A, Kasajima A, Sasano H, Yanai K
  • Journal Title: Glia Volume: 61 Pages: 905-16
  • DOI: 10.1002/glia.22484
  • Peer Reviewed
• [Journal Article] A 18F-Labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography. (2013)
  • Author(s): Shozo Furumoto
  • Journal Title: Mol Imaging Biol. Volume: 15 Pages: 497-506
  • DOI: 10.1007/s11307-012-0608-5
  • Peer Reviewed
• [Journal Article] Brain accumulation of amyloid 13 protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus (2013)
  • Author(s): Tomita N, Furukawa K, Okamura N, Tashiro M, Une K, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
  • Journal Title: Geriatr Gerontol Int Volume: 13 Pages: 215-21
  • DOI: 10.1111/j.1447-0594.2012.00880.x
  • Peer Reviewed
• [Journal Article] ヒスタミンの生理作用 : "善玉"としてのヒスタミン (2013)
  • Author(s): 飯田智光、三浦大和、長沼史登、中村正帆、吉川雄朗、谷内一彦
  • Journal Title: 皮膚アレルギーフロンティア Volume: vol.11 Pages: 65-70
• [Journal Article] 非鎮静性抗ヒスタミン薬の薬理学的特徴 (2013)
  • Author(s): 中村正帆、長沼史登、谷内一彦、吉川雄朗
  • Journal Title: アレルギーの臨床 Volume: 33 Pages: 22-26
• [Journal Article] 「抗ヒスタミン薬はなぜ眠気を誘発するのか?」「数多く存在する抗ヒスタミン薬はどのように分類して考えればよいのか?」「抗ヒスタミン薬同士の併用は意味があるのか?」 (2013)
  • Author(s): 長沼史登、谷内一彦
  • Journal Title: 抗ヒスタミン薬 : 達人の処方箋メディカルレビュー社 Pages: 301-301
• [Journal Article] A F18-Labeled BF-227 Derivative as a Potential Radioligand for Imaging Dense Amyloid Plaques by Positron Emission Tomography. (2013)
  • Author(s): Furumoto S, Okamura N, Furukawa K, Tashiro M, Ishikawa Y, Sugi K, Tomita N, Waragai M, Harada R, Tago T, Iwata R, Yanai K, Arai H, Kudo Y.
  • Journal Title: Mol Imaging Biol. Volume: in press
  • Peer Reviewed
• [Journal Article] Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. (2013)
  • Author(s): Ryuichi Harada
  • Journal Title: European Journal of Nuclear Medicine Volume: 40 Pages: 125-132
  • DOI: 10.1007/s00259-012-2261-2
  • Peer Reviewed
• [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia (2012)
  • Author(s): Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Yanai K, Iwata R, Mori E.
  • Journal Title: Eur Neurol Volume: 68(3) Pages: 137-43
  • Peer Reviewed
• [Journal Article] [(11)C]Doxepin binding to histamine H1 receptors in living human brain: reproducibility during attentive waking and circadian rhythm. (2012)
  • Author(s): KatsuhikoShibuya
  • Journal Title: Front Synt Neurosci Volume: 6 Pages: 45-45
  • DOI: 10.3389/fnsys.2012.00045
  • Peer Reviewed
• [Journal Article] Roles of histamine in exercise-induced fatigue : favouring endurance and protecting against exhaustion (2012)
  • Author(s): Niijima-Yaoita F, Tsuchiya M, Ohtsu H, Yanai K, Sugawara S, Endo Y, Tadano T.
  • Journal Title: Biol Pharm Bull Volume: 35(1) Pages: 91-7
  • NAID: 130001872348
  • Peer Reviewed
• [Journal Article] Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis (2012)
  • Author(s): Furukawa K, Ikeda S, Okamura N, Tashiro M, T omita N, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
  • Journal Title: Circulation Volume: 125 Pages: 556-557
  • DOI: 10.1161/circulationaha.111.045237
  • Peer Reviewed
• [Journal Article] Synthesis of [ 11 C]interleukin 8 using a cell-free translation system and L-[11C]methionine (2012)
  • Author(s): Harada R, Furumoto S, Y oshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Y anai K
  • Journal Title: Nuclear Medicine and Biology Volume: 39 Pages: 155-160
  • DOI: 10.1016/j.nucmedbio.2011.07.005
  • Peer Reviewed
• [Journal Article] 日本をリードするPET橋渡し研究拠点 : 東北大学サイクロトロン・ラジオアイソトーフ。センター (2012)
  • Author(s): 古本祥三、田代学、岩田錬、谷内一彦
  • Journal Title: PET Joumal Volume: 18 Pages: 4-6
• [Journal Article] Rapid biochemical synthesis of C-11-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis (2012)
  • Author(s): Matsuda T., Furumoto S., Higuchia K., Yokoyama J., Zhang M.-R., Yanai K., Iwatad R., Kigawa T.
  • Journal Title: Bioorg Med Chem. Volume: 20 Pages: 6579-6582
  • DOI: 10.1016/j.bmc.2012.09.038
  • Peer Reviewed
• [Journal Article] Cerebral metabolic changes in men after chiropractic spinal manipulation for neck pain (2011)
  • Author(s): Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K.
  • Journal Title: Ahern Ther Health Med Volume: 17(6) Pages: 12-7
  • Peer Reviewed
• [Presentation] Antihistamine Update (2013)
  • Author(s): Kazuhiko Yanai
  • Organizer: 第63回日本アレルギー学会秋季学術大会,日本国内学会
  • Place of Presentation: 東京、日本[基調講演:英語発表]
• [Presentation] Villemagne. Molecular imaging of disease-related pathology in neurodegenerative disorders (2013)
  • Author(s): Kazuhiko Yanai
  • Organizer: The 12^<th> meeting of the Asia Pacific Federation of Pharamacolouists (APFP),海外・国際研究会
  • Place of Presentation: 上海、中国[特別講演・招待講演:英語発表]
  • Invited
• [Presentation] タウイメージングプローブ候補化合物F18標識アリールキノリン誘導体の前臨床評価 (2013)
  • Author(s): 原田龍一、岡村信行、古本祥三、多胡哲郎、吉川雄朗、荒井啓行、岩田錬、谷内一彦、工藤幸司
  • Organizer: 第８６回日本薬理学会
  • Place of Presentation: 福岡
• [Presentation] 遺伝子・組織バンクと医療情報の電子化 (2012)
  • Author(s): 谷内一彦
  • Organizer: 第33回日本臨床薬理学会,日本国内学会
  • Place of Presentation: 沖縄、日本[基調講演]
• [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia (2012)
  • Author(s): Kazuhiko Yanai
  • Organizer: The 21st Korea-Japan Joint Seminar on Pharmacology,海外・国際研究会
  • Place of Presentation: チェジュ島、韓国[特別講演・招待講演:英語発表]
  • Invited
• [Presentation] Molecular imaging of disease-related pathology in neurodegerative dementia (2012)
  • Author(s): Kazuhiko Yanai and Nobuyuki Okamura
  • Organizer: The 21st Korea-Japan Joint Seminar on Pharmacology
  • Place of Presentation: Jeju, Korea
  • Invited
• [Presentation] Plasma membrane monoamine transporter (PMAT) is important for monoamine clearance by human astrocytoma-derived cell line, 1321N1 cells (2012)
  • Author(s): Fumito Naganuma, Takeo Yoshikawa, Tomomitsu Iida, and Kazuhiko Yanai
  • Organizer: The 21st Korea-Japan Joint Seminar on Pharmacology
  • Place of Presentation: Jeju, Korea
• [Presentation] PETを用いた分子イメージング：創薬への応用
  • Author(s): 谷内一彦
  • Organizer: 日本薬理学会
  • Place of Presentation: 仙台
  • Invited
• [Book] ファーマーナビゲーター:抗ヒスタミン薬編 (2012)
  • Author(s): 宮地良樹、岡本美孝、谷内一彦(編・著)
  • Total Pages: 300
  • Publisher: メディカルレビュー社