Development of a system with expanded PK-PD-PG theoretical model to prevent of adverse effects
| Project/Area Number |
24659256
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KOHDA Yukinao 筑波大学, 医学医療系, 教授 (40143482)
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| Co-Investigator(Renkei-kenkyūsha) |
MOMO Kenji 筑波大学, 附属病院, 病院講師 (30645552)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 応用薬理学 / 副作用 / 薬物動態 / 薬物相互作用 / Cytochrome P450 1A2 |
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| Research Abstract |
In the patients treated with tizanidine, approximately 45 % of the patients were co-administered with CYP1A2 inhibitors. Adverse effects induced co-administration of CYP1A2 inhibitors were observed in 23% of these patients. Tizanidine and cimetidine co-administration study was conducted in 6 healthy subjects. The prediction of adverse effects induced by tizanidine in the patients treated with tizanidine and cimetidine wereapplicable by using these data.
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Report
(2 results)
Research Products
(4 results)
