| Project/Area Number |
24659259
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
SOKABE Masahiro 名古屋大学, 医学(系)研究科(研究院), 特任教授 (10093428)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Kiyofumi 名古屋大学, 医学部付属病院, 教授 (30303639)
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| Research Collaborator |
LING Chen 南京医科大学, 生理学, 教授
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アルツハイマー病 / アミロイドβ / 神経ステロイド / PREGS / 治療法開発 / 海馬 / 長期増強 / アセチルコリン受容体 |
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| Research Abstract |
The aim of this study was to test whether the neurosteroids PREGS and DEHA improve the survival rate and function of newborn hippocampal granule cells in the dentate gyrus (DG), which are crucial for learning and memory, by using Alzheimer's disease (AD) model mice. Each mouse was given a daily subcutaneous injection of PREGS or DHEA at a dose of 20 mg/kg for a month, and morphological development of newborn granule cells in the DG was examined for 20 days from the day 20 after the first injection. Both agents largely improved the morphological development of new born cells, but only PREGS facilitated the synaptogenesis of newborn cells to preexisting neural circuits and contributed to the final survival rate of newborn granule cells. It is strongly suggested that PREGS can be a promising therapeutic drug for AD.
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