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A novel strategy for treatment of psychiatric disorder based on a new regulation mechanism of prefrontal dopamine release

Research Project

Project/Area Number 24659261
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionOsaka University

Principal Investigator

MATSUDA Toshio  大阪大学, 薬学研究科(研究院), 教授 (00107103)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsドパミン / σ1受容体 / 5-HT1A受容体 / シグマ1受容体 / セロトニン1A受容体 / シグマ1受容体 / ドパミン遊離 / 前頭葉 / 神経ステロイド / 副腎摘出 / 睾丸摘出
Research Abstract

In the present study, we examined the mechanisms underlying the synergistic effect of combined serotonin reuptake inhibition and sigma-1 receptor activation on prefrontal dopaminergic transmission in circulating steroid hormone-deficient conditions. We also tried to clarify the signal molecules which involved the interaction between the serotonin system and sigma system. We found that combined activation of serotonin-1A and sigma-1 receptors has a synergistic effect on prefrontal dopaminergic transmission under circulating steroid deficiency, VTA-PFC system plays a key role in the combinded effect, and GABA(A) receptor is involved in the effect of the stroid hormone-deficient conditions. Unfortunately, we could not find the in vitro system including functional setrotonin-1A and sigma-1 receptors in the same cell.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (12 results)

  • [Journal Article] Synergistic effect of 5-HT1A andσ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency2013

    • Author(s)
      Hiramatsu N, Ago Y, Hasebe S, Nishimura A, Mori K, Takuma K, Matsuda T.
    • Journal Title

      Neuro- pharmacology

      Volume: 75 Pages: 53-61

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropharmacological studies on brain 5-HT_<1A> receptor using the selective agonist osemozotan2013

    • Author(s)
      Matsuda T.
    • Journal Title

      Biol Pharm Bull

      Volume: 36(12) Pages: 1871-1822

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effect of 5-HT_<1A> and σ_1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency2013

    • Author(s)
      平松 直樹、吾郷 由希夫、長谷 部茂、西村 明、森 和也、田熊 一敞、松田 敏夫
    • Journal Title

      Neuropharmacology

      Volume: 75 Pages: 53-61

    • DOI

      10.1016/j.neuropharm.2013.06.026

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] セロトニン_1A受容体とσ_1受容体活性化による大脳皮質ドパミン遊離調節へのGABA_A受容体の関与2014

    • Author(s)
      平松直樹,森和也,渡部雄二,吾郷由希夫,田熊一敞,松田敏夫
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] セロトニン1A受容体とσ1受容体活性化による大脳皮質ドパミン遊離調節へのGABAA受容体の関与2014

    • Author(s)
      平松直樹, 森 和也, 渡部雄二, 吾郷由希夫, 田熊一敞, 松田 敏夫
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] GABA_A受容体はセロトニン_<1A>受容体、σ_1受容体相互作用による前頭葉ドパミン遊離を調節する2013

    • Author(s)
      森和也,平松直樹,渡部雄二,吾郷由希夫,田熊一敞,松田敏夫
    • Organizer
      第124回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Year and Date
      2013-11-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 前頭皮質ドパミン遊離の新しい調節機構 : GABA_A、セロトニン_1_A、σ_1受容体の機能的相互作用2013

    • Author(s)
      森和也,平松直樹,渡部雄二,吾郷由希夫,田熊一敞,松田敏夫
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京田辺
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] セロトニン_<1A>受容体、σ_1受容体相互作用による大脳皮質ドパミン遊離調節におけるGABA_A受容体の関与2013

    • Author(s)
      森和也,平松直樹,西村明,吾郷由希夫,田熊一敞,松田敏夫
    • Organizer
      第123回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-07-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Enhancement of prefrontal dopamine release by combined activation of 5-HT_<1A> andσ_1 receptors in adrenalectomized/castrated mice. Neurosci- ence 20132013

    • Author(s)
      Hiramatsu N, Ago Y, Mori K, Nishimura A, Takuma K, Matsuda T.
    • Organizer
      SfN's 43nd annual meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Combined activation of 5-HT1A and σ1 receptors enhances prefrontal dopamine release in adrenalectomized/castrated mice2013

    • Author(s)
      平松直樹, 吾郷由希夫, 森 和也, 西村 明, 田熊一敞, 松田敏夫
    • Organizer
      Society for Neuroscience 2013
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhancement of prefrontal dopamine release by combined activation of 5-HT1A and σ1 receptors in adrenalectomized/castrated mice2013

    • Author(s)
      iramatsu N, Ago Y, Mori K, Nishimura A, Takuma K, Matsuda T
    • Organizer
      SfN’s 43nd annual meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] セロトニントランスポーター阻害とシグマ1受容体活性化の相互作用による前頭葉ドパミン遊離調節2012

    • Author(s)
      吾郷由希夫,平松直樹,西村明,田熊一敞,松田敏夫
    • Organizer
      第7回トランスポーター研究会年会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] セロトニン1A受容体、σ1受容体相互作用による大脳皮質ドパミン遊離調節におけるGABAA受容体の関与

    • Author(s)
      森 和也, 平松直樹, 西村 明, 吾郷由希夫, 田熊一敞, 松田敏夫
    • Organizer
      第123回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 前頭皮質ドパミン遊離の新しい調節機構:GABAA、セロトニン1A、σ1受容体の機能的相互作用

    • Author(s)
      森 和也, 平松直樹, 渡部雄二, 吾郷由希夫, 田熊一敞, 松田 敏夫
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京田辺
    • Related Report
      2013 Annual Research Report
  • [Presentation] GABAA受容体はセロトニン1A受容体、σ1受容体相互作用による前頭葉ドパミン遊離を調節する

    • Author(s)
      森 和也, 平松直樹, 渡部雄二, 吾郷由希夫, 田熊一敞, 松田敏夫
    • Organizer
      第124回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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