Search for small RNA molecules in blood as novel diagnostic biomarkers

• Project/Area Number: 24659269
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Niigata University
• Principal Investigator: TAKAHASHI Yoshiaki 新潟大学, 医歯学系, 教授 (60115045)
• Co-Investigator(Kenkyū-buntansha): NASHIMOTO Masayuki 新潟薬科大学, 応用生命科学部, 教授 (30228069)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: バイオマーカー / 低分子RNA / 検査診断 / ncRNA / miRNA / 発現調節

Research Abstract

In this study, we searched for small RNA molecules in blood as novel diagnostic biomarkers. We found many RNA species that exist statistically more or less abundantly in plasma from multiple myeloma patients than in that from healthy persons. Some of them could become diagnostic markers for myeloma. We also showed that some of the RNA species increase or decrease growth of human cultured cells. This suggests that these RNAs may be used as signaling molecules between cells.