Challenges to analyse "placebo-induced analgesia"
| Project/Area Number |
24659291
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKE Sachiko 九州大学, 医学(系)研究科(研究院), 准助教 (80253425)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | placebo / analgesia / animal model / running wheel / anxiety / emotion / prefrontal cortex / amygdala / プラセボ / 条件付け / 疼痛 / 除痛 / 情動 / open field / 自発痛 / 脳内機序 |
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| Outline of Final Research Achievements |
(1) As an animal model of "placebo-induced analgesia", the effects of non-opioid analgesic drugs were conditioned in rats and mice with inflammatory pain. We have established the new assessment system to evaluate the changes of spontaneous activity and emotions such as anxiety, in addition to pain thresholds.
(2) We have shown that the reduction of anxiety is conditioned simultaneously with analgesia, and that the prefrontal cortex and amygdala are involved in "placebo-induced analgesia." The study is still in progress.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure2012
Author(s)
Li L, Morimoto S, Take S, Zhan D.-Y, Du C.-K, Wang Y.-Y, Fan X.-L, Yoshihara T, Takahashi-Yanaga F, Katafuchi T, Sasaguri T
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Journal Title
J Mol Cell Cardiol
Volume: 53
Issue: 6
Pages: 760-767
DOI
Related Report
Peer Reviewed
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