| Project/Area Number |
24659304
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TOMOSUGI Mano (HORINAKA Mano) 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80512037)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マトリックスメタロプロテアーゼ / 癌 / TRAIL / 免疫 |
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| Research Abstract |
TRAIL is cytokine which can induce apoptosis against cancer cells, and has contributed to cancer prevention. We found that matrix metalloproteinase 8 (MMP-8) is one of the key factors responsible for the release of TRAIL, and we have shown that butyric acid bacterium promotes the release of MMP-8 and induces the release of endogenous TRAIL from neutrophils (Int J Oncol, 2013, 42:903).
We therefore hypothesized that we could find the cancer preventive food factors by detecting factors to release MMP-8 with up-regulation of TRAIL. We then performed a screening for a variety of candidates such as the ingredients with immunostimulatory action. However, the candidate with sufficient effect was not found as compared with the butyric acid bacterium.
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