| Project/Area Number |
24659305
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SOWA Yoshihiro 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70315935)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | thymidylate synthase / fenofibrate / PI3K阻害剤 / PI3K/Akt経路 / MAPK経路 |
|---|
| Research Abstract |
Since the activity of thymidylate synthase (TS) is essential for cell proliferation, the expression of TS is higher in various cancer cells than in normal cells. Therefore, we tried to find the suppressors of the expression of TS for cancer prevention. As the results, we found that fenofibrate, which is used to reduce cholesterol levels, reduced the expression of TS in human colon cancer HT-29 cells and that LY294002, a PI3K inhibitor, also reduced it in human colon cancer HCT15 cells. These results raise a possibility that these compounds might be useful for the treatment and prevention against colon cancer.
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