Construction of attenuated human cytomegalovirus vacccine strain which cannnot replicate in human tissues
| Project/Area Number |
24659309
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Gunma University |
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Principal Investigator |
ISOMURA Hiroki 群馬大学, 医学(系)研究科(研究院), 教授 (20294415)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | サイトメガロウイルス / ヒトサイトメガロウイルス |
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| Research Abstract |
We constrcuted the attenuated human cytomegalovius vaccine which cannot replicate in human tissues. HCMV DNA replication and late gene transcription are not completely linked. Viral-encoded trans-acting factors are required. Recombinant viruses proficient in major immediate early and early viral gene expression and defective in late gene expression are therapeutic disabled infectious single cycle(DISC)vaccine candidates for the induction of cell-mediated and humoral immunity.
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Report
(3 results)
Research Products
(2 results)
