Construction of attenuated human cytomegalovirus vacccine strain which cannnot replicate in human tissues

Research Project

Project/Area Number	24659309
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Hygiene
Research Institution	Gunma University
Principal Investigator	ISOMURA Hiroki 群馬大学, 医学(系)研究科(研究院), 教授 (20294415)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	サイトメガロウイルス / ヒトサイトメガロウイルス
Research Abstract	We constrcuted the attenuated human cytomegalovius vaccine which cannot replicate in human tissues. HCMV DNA replication and late gene transcription are not completely linked. Viral-encoded trans-acting factors are required. Recombinant viruses proficient in major immediate early and early viral gene expression and defective in late gene expression are therapeutic disabled infectious single cycle(DISC)vaccine candidates for the induction of cell-mediated and humoral immunity.

Report

(3 results)