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The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies.

Research Project

Project/Area Number 24659316
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionTohoku University (2013)
Yamagata University (2012)

Principal Investigator

SHIBATA Kyoko  東北大学, 大学病院, 特任講師 (90535600)

Co-Investigator(Kenkyū-buntansha) TAMIYA Gen  東北大学, 東北メディカル・メガバンク機構, 教授 (10317745)
Project Period (FY) 2012-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords血縁構造化 / 疫学研究 / 交絡因子 / 血縁構造
Research Abstract

We investigated the confounding effect of unadjusted cryptic relatedness (CR) among a rural cohort in the relationship between environmental risk factors (body mass index, smoking status, alcohol consumption) and systolic blood pressure (SBP). We applied the methods of population-based whole-genome association studies for the analysis of the genome-wide SNP data in 1622 subjects, and detected 20.2% CR in this cohort population. In conclusion, we found a confounding effect of CR in the relationship between SBP and environmental risk factors was not negligible. In our study, we showed that heritability for liability might reflect on the estimation of regression coeffients between SBP and environmental risk factors, because they vary with environmental risk factors that differ across some unsuspected relatedness.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies.2013

    • Author(s)
      Shibata K, Hozawa A, Tamiya G, Ueki M, Nakamura T, et al.
    • Journal Title

      Mol Genet Genomic Med

      Volume: 1 Issue: 1 Pages: 45-53

    • DOI

      10.1002/mgg3.4

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies2012

    • Author(s)
      Shibata K,(以下、10名省略)
    • Organizer
      米国人類遺伝学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2012-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies2012

    • Author(s)
      柴田恭子、寶澤篤、田宮元、植木優、中村智洋、成松宏人、久保田功、上野義之、加藤丈夫、山下英俊、深尾彰、嘉山孝正、山形大学ゲノムコホートコンソーシアム
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      米国サンフランシスコ MOSCONE CTR NORTH
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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